Published Date2019-10-01
JournalIntegrative and comparative biology, 2019-10-01, Volume 59 Find other publications in this journal
Author Info
  • Department of Integrative Biology, University of Texas, Austin, TX 78712, USA.
  • Department of Biological, Geological and Environmental Sciences (BiGeA), University of Bologna, Bologna, 40126, Italy.
  • Division of Biology, Kansas State University, Manhattan, KS 66506, USA.
  • Department of Biological Sciences, University of Memphis, Memphis, TN 38152, USA.
  • Department of Biology, Colgate University, Hamilton, NY 13346, USA.
  • School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.
  • Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA.
  • School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68502, USA.
  • Department of Biology, Portland State University, Portland, OR 97201, USA.
  • Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
  • and 1 more


Eukaryotes are the outcome of an ancient symbiosis and as such, eukaryotic cells fundamentally possess two genomes. As a consequence, gene products encoded by both nuclear and mitochondrial genomes must interact in an intimate and precise fashion to enable aerobic respiration in eukaryotes. This genomic architecture of eukaryotes is proposed to necessitate perpetual coevolution between the nuclear and mitochondrial genomes to maintain coadaptation, but the presence of two genomes also creates the opportunity for intracellular conflict. In the collection of papers that constitute this symposium volume, scientists working in diverse organismal systems spanning vast biological scales address emerging topics in integrative, comparative biology in light of mitonuclear interactions.