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Publication
ID32291105Published Date2020-06-01JournalUltrasound in medicine & biology, 2020-06-01, Volume 46
Quantitative ultrasound has been used to assess carotid plaque tissue composition. Here, we compute the attenuation coefficient (AC) in vivo with the optimum power spectral shift estimator (OPSSE) and reference phantom method (RPM), extract AC parameters and form parametric maps. Differences between OPSSE and RPM AC parameters are computed. Relationships between AC parameters, surgical scores and histopathology assessments are examined. Kendall's τ correlations between OPSSE AC and surgical s…
Publication
ID32587945Published Date2020-05-02JournalJournal of Alzheimer's disease reports, 2020-05-02, Volume 4
A growing body of evidence supports that aerobic exercise can decrease the risk of future cognitive impairment and Alzheimer's disease (AD). There is a pressing need to rigorously determine whether cognitively normal yet at-risk individuals stand to benefit from the protective effects of exercise. The present study will test the feasibility of an aerobic exercise intervention in such a population and inform the design of a larger-scale randomized, controlled trial examining the effect of aero…
Publication
IDDOI:10.3233/adr-200180Published Date2020-05-02JournalJournal of Alzheimer's Disease Reports, 2020-05-02, Volume 4
Publication
ID30681393Published Date2019-02-05JournalJournal of the American Heart Association, 2019-02-05, Volume 8
Background We hypothesized that measures of common carotid artery echolucency and grayscale texture features were associated with cardiovascular disease ( CVD ) risk factors and could predict CVD events. Methods and Results Using a case-cohort design, we measured common carotid artery ultrasound images from 1788 participants in Exam 1 of the MESA study (Multi-Ethnic Study of Atherosclerosis) to derive 4 grayscale features: grayscale median, entropy, gray level difference statistic-contrast, a…
Publication
ID30805597Published Date2019-01-24JournalArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2019-01-24, Volume 35
We examine the relationship between variability in the plaque strain distribution estimated using ultrasound with multiple cognitive domains including executive, language, visuospatial reasoning, and memory function.Asymptomatic (n = 42) and symptomatic (n = 34) patients with significant (>60%) carotid artery stenosis were studied for plaque instability using ultrasound strain imaging and multiple cognitive domains including executive, language, visuospatial reasoning, and memory function. Co…
Publication
ID31240113Published Date2019-01-01JournalBiomedical physics & engineering express, 2019-01-01, Volume 5
Carotid plaque rupture can result in stroke or transient ischemic attack that can be devastating for patients. Ultrasound strain imaging provides a noninvasive method to identify unstable plaque likely to rupture. Axial, lateral and shear strains in carotid plaque have been shown to be linked to carotid plaque instability. Recently, there has been interest in using principal strains, which do not depend on angle of insonification of the carotid artery for quantifying instability in plaque alo…
Publication
ID29970256Published Date2018-09-01JournalAtherosclerosis, 2018-09-01, Volume 276
It is not known if ultrasound carotid plaque features are associated with cardiovascular disease (CVD) risk factors or if they predict future CVD events.We measured total carotid plaque area (TPA) and grayscale plaque features (grayscale median, black areas, and discrete white areas) by B-mode carotid ultrasound among 2205 participants who participated in the first (baseline) visit of the Multi-Ethnic Study of Atherosclerosis. Multivariable linear regression was used to examine relationships …
Publication
ID30035269Published Date2018-05-01JournalJournal of diagnostic medical sonography : JDMS, 2018-05-01, Volume 34
This pilot study evaluated associations between carotid wall echogenicity, cardiovascular disease (CVD) risk factors, and three markers of smoking heaviness in a cohort of active smokers. Common carotid artery (CCA) grayscale median (GSM) values were measured from sonographic images. Univariable correlations and exploratory multivariable models were used to determine associations between CCA GSM, CVD risk factors, and measures of smoking heaviness. CCA GSM was measured in 162 smokers and was …
Publication
ID29308915Published Date2018-04-01JournalThe British journal of radiology, 2018-04-01, Volume 91
This pilot study determined if the ultrasound texture feature "contrast" was associated with cardiovascular disease (CVD) risk factors and subclinical arterial disease.We evaluated ultrasound images of the right common carotid artery (CCA) from a convenience sample of 151 participants and examined relationships between contrast, CVD risk factors, carotid intima-media thickness (IMT) and coronary artery calcium (CAC). Grey level difference statistics algorithms were used to evaluate the textur…
Publication
ID28575478Published Date2018-03-01JournalNeurosurgery, 2018-03-01, Volume 82
Vascular cognitive decline is critically important in the course of atherosclerosis and stroke.To explore the hypothesis that carotid endarterectomy (CEA) by removing an unstable plaque may slow the course of vascular cognitive decline in both symptomatic and asymptomatic patients.Patients with clinically significant (>60%) carotid stenosis were studied preop and 1 yr post-CEA for clinical symptoms, vascular cognitive decline, instability of carotid plaque-presence of microemboli, brain white…
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Publications: 46

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