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Patent
Publication NumberEP 2432776 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2010-05-21Publication Date2019-09-11
Publication
ID28723414Published Date2018-01-01JournalPharmacology & therapeutics, 2018-01-01, Volume 181
Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign hepatosteatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and primary hepatocellular cancer (HCC). Because of its strong association with the obesity epidemic, NAFLD is rapidly becoming a major public health concern worldwide. Surprisingly, there are no FDA approved NAFLD therapies; and current therapies focus …
Patent
Publication NumberHK 1223632 A1Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-10-13Publication Date2017-08-04
Patent
Publication NumberUS 9687561Filing StatusIssued PatentAvailabilityUnknownFiling Date2013-08-14Publication Date2017-06-27
The invention relates to dendrimers conjugated to multiple targeting peptides and one or more therapeutic, diagnostic, or imaging agents for delivery of such agents across the blood-brain barrier and into certain cell types including, cells expressing the LRP-1 receptor. Also described are methods of making compounds that comprise dendrimers conjugated to targeting peptides and therapeutic, diagnostic, or imaging agents.
Patent
Publication NumberUS 20160367691Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2014-06-06Publication Date2016-12-22
The present invention is related to the one-step synthesis of enzyme conjugates and methods for treating or preventing MPS-II by administering such conjugates. In certain embodiments, these compounds can cross the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone.
Patent
Publication NumberUS 20160213760Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2013-11-12Publication Date2016-07-28
The present invention relates to protein conjugates comprising an aprotinin-derived polypeptide, which facilitates transport of the conjugate across the blood-brain barrier, and an antibody moiety that selectively binds a target within the CNS. The protein conjugates are further defined by the inclusion of a linker; by the number of polypeptides conjugated to each antibody moiety; by the positions at which the antibody moiety and the polypeptides are conjugated; and by the larger configuratio…
Patent
Publication NumberMX 2015005982 AFiling StatusPatent ApplicationAvailabilityUnknownFiling Date2013-11-12Publication Date2016-05-31
The present invention relates to protein conjugates comprising an aprotinin-derived polypeptide, which facilitates transport of the conjugate across the blood-brain barrier, and an antibody moiety that selectively binds a target within the CNS. The protein conjugates are further defined by the inclusion of a linker; by the number of polypeptides conjugated to each antibody moiety; by the positions at which the antibody moiety and the polypeptides are conjugated; and by the larger configuratio…
Patent
Publication NumberUS 9315521Filing StatusIssued PatentAvailabilityUnknownFiling Date2015-04-22Publication Date2016-04-19
The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features…
Patent
Publication NumberCY 1113038 T1Filing StatusOtherAvailabilityUnknownFiling Date2012-05-22Publication Date2016-04-13
The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
Patent
Publication NumberEP 3004140 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2014-06-06Publication Date2016-04-13
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