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Publication
ID32163852Published Date2020-06-05JournalJournal of pharmaceutical and biomedical analysis, 2020-06-05, Volume 185
There is a growing trend in the pharmaceutical industry towards substituting conventional chemical synthesis routes of semi-synthetic β-lactam antibiotics (SSBAs) through environmentally sustainable enzymatic processes. These have advantages such as cost reduction in terms of solvent and waste treatment and time saving owing to fewer reaction steps. Penicillin G acylase (PGA) is an industrially important enzyme that is mainly used to catalyze the synthesis of SSBAs. In this study, we establis…
Publication
ID32325553Published Date2020-06-10JournalThe Science of the total environment, 2020-06-10, Volume 720
The combustion and emission characteristics of sludge, biomass (rice husk, peanut husk, pine sawdust) and their blends were studied by non-isothermal thermogravimetry, tube oven method and SEM. The results showed that the combustion process of sludge, biomass and their blends could be divided into three stages: the evaporation of water, the release and combustion of volatile, combustion of char. Combustion characteristics of 80% biomass +20% sludge were improved compared with the theoretical …
Publication
ID32248974Published Date2020-06-04JournalBiochemical and biophysical research communications, 2020-06-04, Volume 526
Long non-coding RNAs (lncRNAs) have been identified as new regulatory factors in tumor progression. Lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1) was a recently identified lncRNA. This research aimed to investigate the roles and mechanisms of LEF1-AS1 in colorectal cancer (CRC). We firstly showed that LEF1-AS1 expression was upregulated in human CRC tissues and cell lines. LEF1-AS1 upregulation was demonstrated to be induced by CREB1. Clinical study revealed that high LEF1-AS1…
Publication
ID32021878Published Date2020-06-12JournalMolecular therapy. Methods & clinical development, 2020-06-12, Volume 17
Amyloid β (Aβ) accumulation in the brain is considered to be one of the major pathological changes in the progression of Alzheimer's disease (AD). Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades Aβ. However, conventional approaches for increasing NEP levels or inducing its activation via viral-vector gene delivery have been shown to be problematic due to complications involving secondary toxicity, immune responses, and/or low gene transfer efficiency. Thus, in the presen…
Publication
ID31928119Published Date2020-06-01JournalPharmaceutical development and technology, 2020-06-01, Volume 25
Naringin (NG) has been proved to have numerous notable biological effects, including anti-inflammatory effect, anti-cancer effect, and anti-ulcer effect, yet there are no clinical preparations of naringin due to its poor solubility and low dissolution rate after oral administration. In this study, in order to overcome these problems, NG was encapsulated into MPEG-PCL micelles (NGMs) by using a thin-film hydration method. NMGs were in a typical core-shell structure, with a mall particle size (…
Publication
ID32251918Published Date2020-06-01JournalJournal of psychiatric research, 2020-06-01, Volume 125
The objective of this study is to assess the global, regional, and national burden of bipolar disorder (BPD) from 1990 to 2017, by gender, age, and social-demographic index (SDI) from the 2017 Global Burden of Disease (GBD) study. We collected detailed information from GBD on the numbers of incidence cases and disability-adjusted life years (DALYs), age-standardized incidence rate (ASIR), and age-standardized DALYs rate (ASDR) during 1990-2017. Estimated annual percentage changes (EAPCs) were…
Publication
ID32064660Published Date2020-06-01JournalClinical and experimental pharmacology & physiology, 2020-06-01, Volume 47
Accumulating reports have demonstrated that long non-coding RNAs (lncRNAs) play critical roles in the occurrence and metastasis of cholangiocarcinoma (CCA). LncRNA myocardial infarction associated transcript (MIAT) has been widely reported in hepatocellular carcinoma, pancreatic cancer and colorectal cancer, but the relationship between MIAT and CCA progression has not yet been investigated. In the present study, we found that the expression of MIAT in CCA tissues was prominently higher than …
Publication
IDDOI:10.1177/0954410020910883Published Date2020-06-01JournalProceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, 2020-06-01, Volume 234
The steady simulation with flow field and heat transfer performance for different rib layouts is investigated. By referring the GE-E3 turbine blade tip (Case 1) profile as a prototype model, four kinds of rib layouts of full rib structure (Case 2), half rib structure connected with suction side (Case 3), half rib structure connected with pressure side (Case 4), and half rib structure in the rear squealer cavity (Case 5) was designed. The availability of k-ω turbulence model was validated thro…
Publication
IDIEEE:8946689Published Date2020-06-01JournalIEEE Transactions on Energy Conversion, 2020-06-01, Volume 35
This article proposes an asymmetrical fault ride-through (FRT) control strategy for the rotor-side converter (RSC) of a doubly fed induction generator (DFIG). The mathematical model of the DFIG is presented in the positive and negative rotating synchronous reference frames. To prevent the RSC from overcurrent under asymmetrical fault conditions, both positive- and negative-sequence components of the rotor current are reduced. Considering the voltage capacity limitation of the RSC, the rotor n…
Publication
IDIEEE:8907391Published Date2020-06-01JournalIEEE Transactions on Power Electronics, 2020-06-01, Volume 35
Compared with silicon insulated-gate bipolar transistor, silicon carbide (SiC) metal–oxide–semiconductor field-effect transistor (mosfet) presents good features that it clearly shows on its switching and thermal performance. However, the fast switching speed of SiC mosfet makes it much more difficult for solving the dynamic voltage imbalance problem caused by the parameter fluctuations of the SiC mosfets and drive circuits when they are connected in series. This article proposes an effective …
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