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 (1-4)-Thiodisaccharides as anticancer agents. Part 5. Evaluation of anticancer activity and investigation of mechanism of action. Publication
ID31882294Published Date2020-02-15JournalBioorganic & medicinal chemistry letters, 2020-02-15, Volume 30
(1-4)-Thiodisaccharides, thiosugars with the 1-4-thio bridge, were recently shown to induce oxidative stress, as well as, apoptosis in cancer cells in the low micromolar range; however, the detailed mechanism of their anticancer action still remains unknown. In order to clarify the mechanism of (1-4)- thiodisaccharides action, we performed a series of tests including cytotoxic, clonogenic and apoptosis assays using an in vitro glioma cancer model with one ATCC cell line U87 and two novel glio…
 Knockout of two BnaMAX1 homologs by CRISPR/Cas9-targeted mutagenesis improves plant architecture and increases yield in rapeseed (Brassica napus L.). Publication
ID31373135Published Date2020-03-01JournalPlant biotechnology journal, 2020-03-01, Volume 18
Plant height and branch number are essential components of rapeseed plant architecture and are directly correlated with its yield. Presently, improvement of plant architecture is a major challenge in rapeseed breeding. In this study, we first verified that the two rapeseed BnaMAX1 genes had redundant functions resembling those of Arabidopsis MAX1, which regulates plant height and axillary bud outgrowth. Therefore, we designed two sgRNAs to edit these BnaMAX1 homologs using the CRISPR/Cas9 sys…
 Linking individuation and organizational identification: Mediation through psychological safety. Publication
ID31503523Published Date2020-01-01JournalThe Journal of social psychology, 2020-01-01, Volume 160
This paper examines how individuation, a view that organizational members are all unique individuals, induces a perception of psychological safety and how perception of psychological safety, in turn, increases one's organizational identification. Results from 66 respondents in Study 1 provided first support for the proposed mechanism. In Study 2, data collected from 176 employees in work organizations also provided evidence for this mediation model. It was found in both studies that individua…
 Opioid free treatment algorithm for ED headache management: Effect on revisit rate. Publication
ID31104781Published Date2020-01-01JournalThe American journal of emergency medicine, 2020-01-01, Volume 38
The opioid epidemic is a crisis leading to over utilization of resources within emergency departments (EDs). We assessed how implementation of an opioid-free headache and migraine treatment algorithm in the ED impacted patient centered outcomes.This was a retrospective review of patients presenting to EDs across a health network with a primary diagnosis of headache or migraine. Two analyses were completed comparing patients presenting before and after implementation of an opioid-free treatmen…
 A Quantitative and Narrative Evaluation of Goodman and Gilman's Pharmacological Basis of Therapeutics. Publication
ID31861770Published Date2019-12-20JournalPharmacy (Basel, Switzerland), 2019-12-20, Volume 8
Goodman and Gilman's (PBT) has been a cornerstone in the education of pharmacists, physicians, and pharmacologists for decades. The objectives of this study were to describe and evaluate the 13 edition of PBT on bases including: (1) author characteristics; (2) recency of citations; (3) conflict of interest (CoI) disclosure; (4) expert evaluation of chapters. Contributors' (N = 115) sex, professional degrees, and presence of undisclosed potential CoI-as reported by the Center for Medicare and …
 Genome-wide associated study identifies NAC42-activated nitrate transporter conferring high nitrogen use efficiency in rice. Publication
ID31754193Published Date2019-11-21JournalNature communications, 2019-11-21, Volume 10
Over-application of nitrogen fertilizer in fields has had a negative impact on both environment and human health. Domesticated rice varieties with high nitrogen use efficiency (NUE) reduce fertilizer for sustainable agriculture. Here, we perform genome-wide association analysis of a diverse rice population displaying extreme nitrogen-related phenotypes over three successive years in the field, and identify an elite haplotype of nitrate transporter OsNPF6.1 that enhances nitrate uptake and con…
 Development of SiGeSn Technique towards Integrated Mid-Infrared Photonics Applications Publication
IDIEEE:8972759Published Date2019-11-06Conference2019 IEEE BiCMOS and Compound semiconductor Integrated Circuits and Technology Symposium (BCICTS)
GeSn DHS and QW lasers and photoconductors have been investigated. For laser, the maximum operation temperature of 270 K and wavelength of 3.5 µm were achieved; for detector, spectral cut-off was measured at 3.6 µm.
 Geriatric Assessment in a Primary Care Environment: A Standardized Patient Case Activity for Interprofessional Students. Publication
ID31911935Published Date2019-10-18JournalMedEdPORTAL : the journal of teaching and learning resources, 2019-10-18, Volume 15
Given the aging population and the benefits of comprehensive geriatric assessment to this subset of patients, an interprofessional education training approach may be advantageous for learners from a number of different health professions.Through intercollegiate collaborations involving seven different colleges, an interprofessional simulation using standardized patients was developed and instituted for learners in medicine, nursing, pharmacy, occupational therapy, physical therapy, dental hyg…
 Si-Based GeSn Photodetector for Mid-Infrared Integrated Microwave Photonics Publication
IDIEEE:8892042Published Date2019-10-10Conference2019 International Topical Meeting on Microwave Photonics (MWP)
A high-speed Si-based Germanium-Tin (GeSn) photodetector is designed and simulated for infrared integrated microwave photonic applications. The design is based on the CVD-grown GeSn bulk NIP photodetector structure with 8% Sn composition optimized for the detection wavelength up to 2 um that can be extended to mid and far infrared spectra with higher Sn compositions. The electrical direct current (DC) and frequency response simulation results showed the responsivity of 0.02 A/W and maximum -3…
 Free Carrier Plasma GeSn Modulator for Mid-Infrared Integrated Microwave Photonics Publication
IDIEEE:8892134Published Date2019-10-10Conference2019 International Topical Meeting on Microwave Photonics (MWP)
A high-speed Si-based Free Carrier Plasma (FCP) GeSn Germanium-Tin (GeSn) modulator is designed and simulated for infrared integrated microwave photonic applications. The design is based on the capabilities to grow GeSn on Si using CVD method. The structure is composed of a laterally doped p-i-n Ge0.95Sn0.05 rib waveguide for modulation at $2 \mu \mathrm{m}$. The refractive index changes as a result of applied voltage is observed in the device. The transient effective refractive index change …
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