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Patent
Publication NumberUS 10502730Filing StatusIssued PatentAvailabilityUnknownFiling Date2018-06-07Publication Date2019-12-10
A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untitled configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.
Publication
ID31590935Published Date2019-10-31JournalVaccine, 2019-10-31, Volume 37
Influenza virus-like particles (VLPs) represent an attractive alternative to traditional influenza vaccine formulations. Influenza VLPs mimic the natural virus while lacking the genetic material, are easily recognized by the immune system, and are considered safe. The use of a mammalian cell platform offers many advantages for VLP production, such as flexibility and the same glycosylation patterns as a human virus. In this study, the influenza VLPs containing hemagglutinin (HA), neuraminidase…
Patent
Publication NumberEP 3510143 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-09-07Publication Date2019-07-17
Patent
Publication NumberUS 20190187127Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-09-07Publication Date2019-06-20
In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular resp…
Patent
Publication NumberIL 265209 D0Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-03-07Publication Date2019-05-30
In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular resp…
Patent
Publication NumberAU 2017325009 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-09-07Publication Date2019-03-21
In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular resp…
Publication
ID29736810Published Date2018-10-01JournalCytotechnology, 2018-10-01, Volume 70
Although a variety of assays have been used to examine T cell responses in vitro, standardized ex vivo detection of antigen-specific CD4 T cells from human circulatory PBMCs remains constrained by low-dimensional characterization outputs and the need for polyclonal, mitogen-induced expansion methods to generate detectable response signals. To overcome these limitations, we developed a novel methodology utilizing antigen-pulsed autologous human dendritic target cells in a rapid and sensitive a…
Patent
Publication NumberUS 10012643Filing StatusIssued PatentAvailabilityUnknownFiling Date2015-07-28Publication Date2018-07-03
A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untilted configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.
Patent
Publication NumberEP 2491394 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2010-10-20Publication Date2018-04-18
Patent
Publication NumberWO 2018048988 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-09-07Publication Date2018-03-15
In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular resp…
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