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Publication
ID30964765Published Date2019-05-22JournalNeuroreport, 2019-05-22, Volume 30
Early exposure to anesthetics may interfere with synaptic development and lead to cognitive deficits. We previously demonstrated a decrease in vesicles docked at and within 100 nm from the presynaptic membrane in hippocampal nerve terminals of neonatal rats after anesthesia. Hence, we designed this study to assess the effects of neonatal anesthesia on synapsin 1 (Syn1) and synaptotagmin 1 (Syt1), two key regulators of vesicle docking and fusion. To test the link between changes in Syn1 and Sy…
Publication
ID30905349Published Date2019-06-01JournalBiochimica et biophysica acta. Molecular and cell biology of lipids, 2019-06-01, Volume 1864
The metabolic serine hydrolases hydrolyze ester, amide, or thioester bonds found in broad small molecule substrates using a conserved activated serine nucleophile. The mammalian central nervous system (CNS) express a diverse repertoire of serine hydrolases that act as (phospho)lipases or lipid amidases to regulate lipid metabolism and signaling vital for normal neurocognitive function and CNS integrity. Advances in genomic DNA sequencing have provided evidence for the role of these lipid-meta…
Publication
ID29651915Published Date2019-06-01JournalJournal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019-06-01, Volume 25
Methotrexate is a dihydrofolate reductase inhibitor that interferes with DNA synthesis, DNA repair, and cellular replication. We present the first adult case of a patient who received intravenous contrast prior to administration of high-dose methotrexate, who subsequently experienced delayed methotrexate clearance and renal impairment necessitating the use of glucarpidase. This case displays a possible correlation between intravenous radiographic contrast administration and resulting toxicity…
Publication
ID30911698Published Date2019-06-01JournalAmerican journal of ophthalmology case reports, 2019-06-01, Volume 14
To report a case of unilateral leukemic retinopathy secondary to chronic myeloid leukemia (CML).Patient presented to clinic with a visual acuity (VA) of 20/200 in the right eye (OD) after several months of progressive monocular vision loss and was found to have dense pre-retinal hemorrhage. Patient underwent 23-gauge pars plana vitrectomy to clear the preretinal hemorrhage along with a complex macula-off retinal detachment repair to address retinal tear and multilayer retinal hemorrhage. The …
Publication
ID30628493Published Date2019-06-01JournalExpert review of pharmacoeconomics & outcomes research, 2019-06-01, Volume 19
Poor prescription drug adherence is common, jeopardizing the benefits of treatment and increasing the costs of health care in the United States. A frequently reported barrier to adherence is patient out-of-pocket (OOP) costs. Areas Covered: This systematic review examines interventions that address patient cost-sharing to improve adherence to prescription drugs and reduce costs of care. Twenty-eight published studies were identified with 22 distinct interventions. Most papers were published i…
Research Grant
Award Number1850479Funding AgencyNational Science FoundationEffective Date2019-06-01Expiration Date2021-05-31Funding Amount$174,977
Mobile users hold people's sensitive information such as passwords, locations, and health information. Users are permitted to control the use of some of this information by configuring their privacy settings in the apps they use. These settings, however, are often difficult to locate and understand, even in popular apps such as Facebook. Moreover, the settings are often set to share user data by default, exposing personal data without users' explicit consent. The goal of the project is to dev…
Publication
ID30465701Published Date2019-06-01JournalThe International journal of neuroscience, 2019-06-01, Volume 129
Metabolic syndrome is a cluster of cardiovascular risk factors associated with a prothrombotic, proinflammatory and hypofibrinolysis state. Although resistance to tissue plasminogen activator (tPA) in metabolic syndrome patients has been associated with a defective fibrinolytic system, the factors and mechanisms underlining such resistance is unclear. While there is a great debate on proposed mechanisms, fundamental questions regarding resistance to tPA in metabolic syndrome patients with isc…
Research Grant
Award Number1847154Funding AgencyNational Science FoundationEffective Date2019-06-01Expiration Date2024-05-31Funding Amount$500,000
This project aims to transform microscopy from the current low-speed benchtop system into the first-of-a-kind high-speed miniature/portable device that will enable wearable, handheld applications. The microscope will include many of the currently available separate optical modalities into a single multi-parameter system. The proposed system will retain these modalities with no reduction in performance yet with improved portability, reduction in size, and increased data collection efficiency f…
Publication
ID30856574Published Date2019-06-10JournalThe Science of the total environment, 2019-06-10, Volume 668
Biomonitoring of human breast milk is one of the best ways to identify body burdens of contaminants and associated risk estimation. The objectives of the current study were to evaluate milk concentrations of persistent organic pollutants (POPs), mainly polycyclic aromatic hydrocarbons (PAHs), associated exposure estimation, and the role of body mass index (BMI) in their bioaccumulation. A total of 45 breast milk samples were collected from 24 women with BMI > 30 (obese) and 21 women with BMI …
Publication
ID30822632Published Date2019-05-05JournalJournal of hazardous materials, 2019-05-05, Volume 369
Effects of Fe(III)/sulfate (Fe/S) ratio on organic carbon oxidation kinetics and microbial ecology of a novel Fe(III)-dosed anaerobic wastewater treatment system were investigated in this study. Fixed-film batch bioreactors under three Fe/S molar ratios (1, 2, and 3) yielded COD oxidation rates that increased with the Fe/S ratio, and estimated Michaelis-Menten model parameters V ranging in 0.47-1.09 mg/L⋅min and K in 2503-3267 mg/L. Both iron and sulfate reducing bacteria contributed to the o…
We found 75,855 documents that match your Search
Research Grants: 21,069
Publications: 51,126
Patents: 1,534
Clinical Trials: 1,629
Opportunities: 115
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