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Publication
ID31924651Published Date2020-02-15JournalJournal of immunology (Baltimore, Md. : 1950), 2020-02-15, Volume 204
Asthma is a chronic disorder characterized by inflammation, mucus metaplasia, airway remodeling, and hyperresponsiveness. We recently showed that IL-1-induced glycolytic reprogramming contributes to allergic airway disease using a murine house dust mite model. Moreover, levels of pyruvate kinase M2 (PKM2) were increased in this model as well as in nasal epithelial cells from asthmatics as compared with healthy controls. Although the tetramer form of PKM2 converts phosphoenolpyruvate to pyruva…
Publication
ID31794513Published Date2020-03-01JournalAnesthesiology, 2020-03-01, Volume 132
Despite the significant healthcare impact of acute kidney injury, little is known regarding prevention. Single-center data have implicated hypotension in developing postoperative acute kidney injury. The generalizability of this finding and the interaction between hypotension and baseline patient disease burden remain unknown. The authors sought to determine whether the association between intraoperative hypotension and acute kidney injury varies by preoperative risk.Major noncardiac surgical…
Publication
ID31859403Published Date2020-03-01JournalThe Journal of school health, 2020-03-01, Volume 90
Exercise reduces the odds of sadness and suicidality in bullied students, but the role of the bullying environment on this relationship remains unknown.Using combined data from the 2013 and 2015 Youth Risk Behavior Survey (N = 29,207), adjusted logistic regression models estimated odds ratios between exercise, sadness, and suicidal ideation and attempt, stratified by bullying exposure (electronically/at school).Overall, 40.2% of students bullied at school and 48.3% of students bullied electro…
Publication
ID31856422Published Date2020-03-01JournalJournal of peptide science : an official publication of the European Peptide Society, 2020-03-01, Volume 26
There are many examples of bioactive, disulfide-rich peptides and proteins whose biological activity relies on proper disulfide connectivity. Regioselective disulfide bond formation is a strategy for the synthesis of these bioactive peptides, but many of these methods suffer from a lack of orthogonality between pairs of protected cysteine (Cys) residues, efficiency, and high yields. Here, we show the utilization of 2,2'-dipyridyl diselenide (PySeSePy) as a chemical tool for the removal of Cys…
Publication
ID31849078Published Date2020-03-01JournalChild: care, health and development, 2020-03-01, Volume 46
Early home support for language development is critical for later developmental progress. Paediatricians have the opportunity to identify families at risk of failing to provide this support in infancy but often lack simple tools to do so. This study explores the potential of a simple count of sociodemographic risk factors, a cumulative risk (CR) index, to identify families likely to need help in providing literacy support from an early age.CR scores were calculated for 308 families who comple…
Publication
IDDOI:10.1093/mnras/stz3461Published Date2020-02-11JournalMonthly Notices of the Royal Astronomical Society, 2020-02-11, Volume 492
ABSTRACT To date several probes have been sent to explore the Solar system’s asteroids and comets. These bodies are often irregular in shape and to safely navigate probes in their vicinity accurate gravity models are required. For an arbitrarily shaped constant-density body, the gravitational field can be determined from the surface topology and bulk properties. This is achieved by replacing the body’s true geometry with a polyhedron that closely resembles it and for which analytic equations …
Publication
ID32039655Published Date2020-02-10JournalJournal of the Air & Waste Management Association (1995), 2020-02-10
A study was undertaken to identify patterns of consumer use of outdoor wood boilers or outdoor wood furnaces (technically referred to as outdoor wood-fired hydronic heaters (OWHHs)) and indoor wood stoves (IWSs) to inform the development of performance testing protocols that reflect real-life operating conditions. These devices are manually fed, and their usage pro are a function of a number of variables, including user habits, household characteristics, and environmental factors. In this stu…
Publication
ID32032968Published Date2020-02-07JournalNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020-02-07
Cigarette smoking is associated with increased risk for myriad health consequences including cognitive decline and dementia, but research on the link between smoking and brain structure is nascent. In the current study, we assessed the relationship of cigarette smoking with gray matter (GM) and white matter (WM) in the UK Biobank, controlling for numerous confounding demographic and health variables. We used negative-binomial regression to model the association of cigarette smoking (having ev…
Patent
Publication NumberUS 20200038663Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-10-06Publication Date2020-02-06
According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart r…
Publication
ID32027531Published Date2020-02-06JournalArtificial life, 2020-02-06
Many factors influence the evolvability of populations, and this article illustrates how intrinsic mortality (death induced through internal factors) in an evolving population contributes favorably to evolvability on a fixed deceptive fitness landscape. We test for evolvability using the hierarchical if-and-only-if (H-IFF) function as a deceptive fitness landscape together with a steady state genetic algorithm (SSGA) with a variable mutation rate and indiscriminate intrinsic mortality rate. T…
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Publications: 10,468
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