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Publication
ID32445228Published Date2020-05-22JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020-05-22
In the Active-Controlled Fracture Study in Postmenopausal Women With Osteoporosis at High Risk (ARCH) clinical trial (NCT01631214), 1 year of romosozumab followed by alendronate reduced the risk of vertebral and nonvertebral fractures compared to alendronate alone in women with prevalent fracture. We performed post hoc analyses of data from patients in ARCH (romosozumab, n = 1739; alendronate, n = 1726) who had a baseline BMD measurement and received at least one open-label alendronate dose. …
Publication
ID32249249Published Date2020-05-10JournalAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2020-05-10, Volume 36
A simple digestion method for a mixed cellulose membrane filter in order to analyze trace elements in aerosols was examined. The determination of Cu, Fe and Ni in the certified reference materials of China loess (CJ-1) could be conducted using the digestion method. Trace elements in aerosols smaller than 10 μm size collected at Tokushima City and near mountain areas for each season were determined as a water-soluble fraction and all components by the digestion method. Back trajectory analysis…
Publication
ID32366944Published Date2020-05-04JournalNature communications, 2020-05-04, Volume 11
The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood. Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its influence on CD1d-restricted iNKT cells. We find three distinct mTEC subsets distinguished by surface, intracellular and secreted molecules, and identify LTβR as a cell-autonomous controller of their development. Importantly, this mTEC heterogeneity enables …
Publication
ID32358541Published Date2020-05-01JournalNature communications, 2020-05-01, Volume 11
Diatomic carbon (C) is historically an elusive chemical species. It has long been believed that the generation of C requires extremely high physical energy, such as an electric carbon arc or multiple photon excitation, and so it has been the general consensus that the inherent nature of C in the ground state is experimentally inaccessible. Here, we present the chemical synthesis of C from a hypervalent alkynyl-λ-iodane in a flask at room temperature or below, providing experimental evidence t…
Publication
ID32238726Published Date2020-04-02JournalInternal medicine (Tokyo, Japan), 2020-04-02
A 65-year-old woman with spinocerebellar ataxia presented with generalized seizures due to subcortical hemorrhaging. Magnetic resonance imaging (MRI) revealed obstruction of the superior sagittal sinus. Despite treatment, she became comatose. MRI newly revealed subdural fluid collection and descent of the brainstem. Her history indicated a recent fall, prompting additional studies, which revealed lumbar fracture and cerebrospinal fluid (CSF) leaks. We performed an epidural blood patch, and he…
Publication
ID32273818Published Date2020-04-01JournalReproductive medicine and biology, 2020-04-01, Volume 19
We studied the influence of psychological stress during the early neonatal period on sexual maturation and sexual behavior in rats.Neonatal male and female rats were divided into control (C) and maternal separation (MS) groups (n = 20-24 per group). The pups in the MS groups were placed in isolation cages for 240 minutes/d from postnatal days 2-11. Vaginal opening (VO) in females and preputial separation (PS) in males (indicators of sexual maturation) were monitored, as was the estrous cycle …
Publication
ID32007805Published Date2020-04-01JournalNutrition (Burbank, Los Angeles County, Calif.), 2020-04-01, Volume 72
The ratio of dietary carbohydrate to fat may affect phosphorus metabolism because both calcium and phosphorus are regulated by similar metabolic mechanisms, and a high-fat diet (HFD) induces deleterious effects on the absorption of dietary calcium. We hypothesized that an HFD induces an increase in phosphorus absorption. The aim of this study was to evaluate the effects of differences in the quantity and quality of dietary fat on phosphorus metabolism over the short- and long-term.Eighteen 8-…
Publication
ID32234875Published Date2020-04-01JournalAnticancer research, 2020-04-01, Volume 40
The method of quickly identifying metastatic mediastinal lymph nodes has become an urgent problem for lung cancer surgery. Indocyanine green (ICG) has the characteristic of being retained in or around the lymph nodes; its pharmacokinetic characteristics and optimal imaging time have not yet been elucidated.The IVIS Lumina Imaging System was used to detect near infrared (NIR) fluorescence signals at different ICG doses, times and excitation/emission wavelengths in vitro. An artificial lymphoge…
Publication
ID31991021Published Date2020-04-01JournalCancer science, 2020-04-01, Volume 111
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Therefore, it is important to establish useful methods for preventing CRC. One prevention strategy involves the use of cancer chemopreventive agents, including functional foods. We focused on the well-known cancer chemopreventive agent curcumin, which is derived from turmeric. However, curcumin has the disadvantage of being poorly soluble in water due to its high hydrophobicity. To overcome this problem, the format…
Clinical Trial
Clinical Trial IDWHO:JPRN-UMIN000039616Start Date2020-04-01Completion Date2024-12-31PhaseN/AStudy TypeInterventionalStatusPending
We found 15,565 documents that match your Search
Research Grants: 7
Publications: 15,346
Patents: 135
Clinical Trials: 77

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