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Publication
IDDOI:10.1177/0018578720928264Published Date2020-06-17JournalHospital Pharmacy, 2020-06-17
Purpose The purpose of this article is to assist the pharmacist engaged in nutrition support therapy in staying current with pertinent literature. Methods: Several clinical pharmacists engaged in nutrition support therapy compiled a list of articles published in 2019 considered important to their clinical practice. The citation list was compiled into a single spreadsheet where the author participants were asked to assess whether the article was considered important to nutrition support pharma…
Patent
Publication NumberUS 10677914Filing StatusIssued PatentAvailabilityUnknownFiling Date2018-12-05Publication Date2020-06-09
In one embodiment, a method for detecting buried objects includes receiving ground penetrating radar (GPR) signals captured at discrete locations along a surface of a medium in which an object may be buried, computing parameters based on the received GPR signals that are indicative of the proximity of a buried object, plotting the computed parameters as a function of location, determining an apex of a hyperbola that results from the plotting of the computed parameters, and designating a locat…
Publication
ID32375470Published Date2020-06-03JournalJournal of the American Chemical Society, 2020-06-03, Volume 142
Synthetic water channels were developed with an aim to replace aquaporins for possible uses in water purification, while concurrently retaining aquaporins' ability to conduct highly selective superfast water transport. Among the currently available synthetic water channel systems, none possesses water transport properties that parallel those of aquaporins. In this report, we present the first synthetic water channel system with intriguing aquaproin-like features. Employing a "sticky end"-medi…
Publication
ID31601131Published Date2020-06-01JournalJournal of drug targeting, 2020-06-01, Volume 28
Details of intracellular pathways of cytotoxicity remain unclear for doxorubicin conjugates being studied to treat breast cancer tumours. A high molecular weight gelatine-doxorubicin conjugate was investigated with an emphasis on lysosome participation. The conjugate was synthesised and characterised. Cell uptake and cellular localisation in MCF-7 and triple negative breast cancer (TNBC) MDA-MB-231 cells were determined with fluorescence microscopy. Nuclear content of released DOX was determi…
Publication
ID32365312Published Date2020-05-01JournalThe American journal of occupational therapy : official publication of the American Occupational Therapy Association, 2020-05-01, Volume 74
Reports on the integration of 3D printing in occupational therapy education and changes in student acceptance of technology over time are lacking.3D printing technology applications may offer effective solutions to increase client participation in occupations. However, the use of these applications in occupational therapy practice requires attention to occupational therapy students' perception of the technology's usefulness and ease of use. Students' perception of technology potentially influ…
Research Grant
Project Number5R03AG063295-02Funding AgencyNational Institutes of HealthEffective Date2020-04-01Expiration Date2021-03-31Funding Amount$142,500
PROJECT SUMMARY In Alzheimer?s disease (AD) and other tauopathies (e.g. frontemporal dementia, progressive supranuclear palsy, and corticobasal degeneration), the microtubule-associated protein tau abnormally misfolds and accumulates into insoluble, amyloid inclusions that are visible as intra-neuronal ?neurofibrillary tangles? (NFTs) in post-mortem brain analyses. NFTs affect specific brain regions in these diseases, suggesting selective vulnerability of certain neuronal cell types and/or ne…
Publication
ID32072576Published Date2020-03-01JournalTherapeutic innovation & regulatory science, 2020-03-01, Volume 54
The Open Payments database represents a new, substantial source of information on the US clinical trial investigator landscape.This paper draws upon the Open Payments database. This database, mandated by the US Sunshine Act, does help provide a vital missing element in understanding the commercial clinical trial landscape in the United States: comprehensive, detailed, clinical investigator and site information by specific clinical trial. Pharmaceutical companies are required to report all pay…
Publication
ID32108738Published Date2020-03-01JournalNursing research, 2020-03-01, Volume 69
Mild cognitive impairment frequently represents a predementia stage of Alzheimer's disease. Although obstructive sleep apnea is increasingly recognized as a common comorbidity of mild cognitive impairment, most apnea research has focused on middle-aged adults with moderate-to-severe obstructive sleep apnea. Mild obstructive sleep apnea, defined as 5-14 apneas or hypopneas per hour slept, is common in older adults. Little is known about the effect on cognition of adherence to continuous positi…
Publication
ID32020017Published Date2020-02-04JournalScientific reports, 2020-02-04, Volume 10
Chemoresistance is one of the leading causes of mortality in breast cancer (BC). Understanding the molecules regulating chemoresistance is critical in order to combat chemoresistant BC. Drug efflux pump ABCB1 is overexpressed in chemoresistant neoplasms where it effluxes various chemotherapeutic agents from cells. Because it is expressed in normal and cancerous cells alike, attempts at targeting ABCB1 directly have failed due to low specificity and disruption of normal tissue. A proposed meth…
Publication
ID30827254Published Date2020-01-01JournalMedicinal chemistry (Shariqah (United Arab Emirates)), 2020-01-01, Volume 16
Novel bicycloheptylamines were designed and synthesized. These compounds were found to be selective for sigma-2 receptors. These receptors have been found to be up to 10 fold over-expressed in certain cancer cell lines, leading to investigation of possible uses as a biomarker in diagnosis and/or treatment especially in cancers with poor prognosis.The aim was to conjugate a novel sigma-2 receptor ligand to doxorubicin to examine anticancer activities, with and without conjugation, and therefor…
We found 810 documents that match your Search
Research Grants: 118
Publications: 656
Patents: 24
Clinical Trials: 12

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