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ID31292602Published Date2019-07-11JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019-07-11
Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma of the anus compared with the general population of women. Anal high-grade squamous intraepithelial lesions (HSILs) precede anal cancer, and accurate studies of HSIL prevalence among WLHIV in the United States are lacking.The AIDS Malignancy Consortium 084 study was a multicenter national trial to evaluate the prevalence of and risk factors for anal HSIL in a US cohort. Eligibl…
Publication
ID31294792Published Date2019-07-11JournalJournal of the American Medical Informatics Association : JAMIA, 2019-07-11
Active Learning (AL) attempts to reduce annotation cost (ie, time) by selecting the most informative examples for annotation. Most approaches tacitly (and unrealistically) assume that the cost for annotating each sample is identical. This study introduces a cost-aware AL method, which simultaneously models both the annotation cost and the informativeness of the samples and evaluates both via simulation and user studies.We designed a novel, cost-aware AL algorithm (Cost-CAUSE) for annotating c…
Publication
ID31294817Published Date2019-07-11JournalNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2019-07-11
FTND (Fagerstrӧm test for nicotine dependence) and TTFC (time to smoke first cigarette in the morning) are common measures of nicotine dependence (ND). However, genome-wide meta-analysis for these phenotypes has not been reported.Genome-wide meta-analyses for FTND (N = 19,431) and TTFC (N = 18,567) phenotypes were conducted for adult smokers of European ancestry from 14 independent cohorts.We found that SORBS2 on 4q35 (p = 4.05 × 10-8), BG182718 on 11q22 (p = 1.02 × 10-8), and AA333164 on 14q…
Publication
ID31294477Published Date2019-07-11JournalThe EMBO journal, 2019-07-11
Collagen linearization is a hallmark of aggressive tumors and a key pathogenic event that promotes cancer cell invasion and metastasis. Cell-generated mechanical tension has been proposed to contribute to collagen linearization in tumors, but it is unknown whether other mechanisms play prominent roles in this process. Here, we show that the secretome of cancer cells is by itself able to induce collagen linearization independently of cell-generated mechanical forces. Among the tumor cell-secre…
Publication
ID31291871Published Date2019-07-10JournalCurrent medicinal chemistry, 2019-07-10
Traumatic brain injury (TBI) is a major public health problem. It is the leading cause of death and disability, especially among children and young adults. The neurobiology basis underlying TBI pathophysiology remains to be fully revealed. Over the past years, emerging evidence has supported the hypothesis that TBI is an inflammatory based condition, paving the way for the development of potential therapeutic targets. There is no treatment capable to prevent or minimize TBI-associated outcome…
Publication
ID31292905Published Date2019-07-10JournalJournal of general internal medicine, 2019-07-10
Workload from electronic health record (EHR) inbox notifications leads to information overload and contributes to job dissatisfaction and physician burnout. Better understanding of physicians' inbox requirements and workflows could optimize inbox designs, enhance efficiency, and reduce safety risks from information overload.We conducted a mixed-methods study to identify strategies to enhance EHR inbox design and workflow. First, we performed a secondary analysis of national survey data of all…
Publication
ID31158395Published Date2019-08-01JournalPharmacology, biochemistry, and behavior, 2019-08-01, Volume 183
The present study evaluated the effects of the coadministration of lithium (Li) and Cel on inflammatory parameters in an animal model of mania induced by dextroamphetamine (D-amph). It was used Wistar rats 60 days old (250-350 g). The animals (n = 10 per group) received D-amph (2 mg/kg) or saline solution of NaCl 0.9% (Sal) intraperitoneally once a day for 14 days. From day eight until 14, the animals from the D-amph and Sal groups received Li (24 mg/kg), Cel (20 mg/kg), Li + Cel or water via…
Publication
ID31082652Published Date2019-08-01JournalJournal of psychiatric research, 2019-08-01, Volume 115
A relationship between neuroinflammation and the development of psychiatric disorder have been revealed by many studies in the past decade. Although studies have shown that stressors can induce long-term changes that may be related to behavioral responses, these alterations have been poorly studied soon after a stressor, such as maternal deprivation (MD). Thus, this study was designed to investigate the acute effect of experimental induction of MD on inflammatory and microglial activation mar…
Publication
ID30948202Published Date2019-08-01JournalPatient education and counseling, 2019-08-01, Volume 102
This study 1) defines patient involvement from the perspective of patients new to a provider, 2) describes provider communication that patients perceive as promoting involvement, and 3) examines changes in patient definitions of involvement over time.We enrolled 56 patients at two HIV clinics in Houston, Texas, from August 2013 until March 2015. We interviewed patients three times during the first year of care and analyzed interviews using content analysis.The mean age was 45 years; 54% were …
Publication
ID31125858Published Date2019-08-01JournalJournal of affective disorders, 2019-08-01, Volume 255
The search for biomarkers of bipolar disorder (BD), including epigenetic alterations, has heavily relied on peripheral investigations that do not necessarily reflect brain-specific mechanisms. In this study we aimed to assess peripheral extracellular vesicles (EVs)' microRNAs and determine their use as a novel source of biomarkers in BD.We assessed peripheral blood EVs' microRNAs from 20 patients with BD type I and 21 age- and sex-matched healthy controls by microarray, and further explored t…
We found 26,808 documents that match your Search
Research Grants: 9,749
Publications: 15,860
Patents: 68
Clinical Trials: 1,003
Web Documents: 128

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