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ID31597707Published Date2019-11-15JournalJournal of immunology (Baltimore, Md. : 1950), 2019-11-15, Volume 203
Infection with is acquired through ingestion of contaminated foods and may lead to systemic infection and possible death, with an overall 20% mortality rate. Our previous work using C5aR1 mice and C3aR mice demonstrated that C5aR1 and C3aR both play powerful anti-inflammatory and prosurvival roles during systemic infection with In our current study, we have examined the role of the third anaphylatoxin receptor, C5aR2, in the host immune response to systemic infection. C5aR2 mice had significa…
Publication
ID31688885Published Date2019-11-05JournalJAMA, 2019-11-05, Volume 322
Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders.To perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma.A 2-stage GWAS with a …
Publication
ID31685530Published Date2019-11-04JournalInjury prevention : journal of the International Society for Child and Adolescent Injury Prevention, 2019-11-04
To examine the reciprocal longitudinal associations between depression or anxiety with work-related injury (WRI) at a large employer in the southwestern United States.Three administrative datasets (2011-2013) were merged: employee eligibility, medical and prescription claims, and workers' compensation claims. The sample contained 69 066 active employees. Depression and anxiety were defined as episodes of medical visits care (ie, claims) with corresponding ICD-9-CM codes. For an individual's c…
Publication
ID31680631Published Date2019-11-04JournalMultiple sclerosis (Houndmills, Basingstoke, England), 2019-11-04
Diroximel fumarate (DRF) is a novel oral fumarate for patients with relapsing-remitting multiple sclerosis (RRMS). DRF and the approved drug dimethyl fumarate yield bioequivalent exposure to the active metabolite monomethyl fumarate; thus, efficacy/safety profiles are expected to be similar. However, DRF's distinct chemical structure may result in a differentiated gastrointestinal (GI) tolerability profile.To report interim safety/efficacy findings from patients in the ongoing EVOLVE-MS-1 stu…
Publication
ID31688227Published Date2019-11-04JournalCurrent opinion in ophthalmology, 2019-11-04
This review aims to cover the preoperative planning, intraoperative considerations, and postoperative management that aids in successful outcomes of patients with cataract and uveitis. Disease-specific management and pediatric management will also be addressed.Dexamethasone implants appear to be a safe and effective addition to standard steroid treatment in decreasing the incidence of postoperative cystoid macular edema (CME). Intravitreal steroids and topical difluprednate have shown utility…
Publication
ID31684782Published Date2019-11-04JournalJournal of intensive care medicine, 2019-11-04
Few studies have examined whether community factors mediate the relationship between patients surviving cancer and future development of sepsis. We determined the influence of community characteristics upon risk of sepsis after cancer, and whether there are differences by race.We performed a prospective analysis using data from the REasons for Geographic and Racial Differences in Stroke cohort years 2003 to 2012 complemented with county-level community characteristics from the American Commun…
Publication
ID31680168Published Date2019-11-04JournalNucleic acids research, 2019-11-04
Assessing the causal tissues of human traits and diseases is important for better interpreting trait-associated genetic variants, understanding disease etiology, and improving treatment strategies. Here, we present a reference database for trait-associated tissue specificity based on genome-wide association study (GWAS) results, named Tissue-Specific Enrichment Analysis DataBase (TSEA-DB, available at https://bioinfo.uth.edu/TSEADB/). We collected GWAS summary statistics data for a wide range…
Publication
ID31684113Published Date2019-11-02JournalCancers, 2019-11-02, Volume 11
Melanoma is a heterogeneous neoplasm at the histomorphologic, immunophenotypic, and molecular levels. Melanoma with extreme histomorphologic heterogeneity can pose a diagnostic challenge in which the diagnosis may predominantly rely on its immunophenotypic profile. However, tumor survival and response to therapy are linked to tumor genetic heterogeneity rather than tumor morphology. Therefore, understating the molecular characteristics of such melanomas become indispensable. In this study, DN…
Publication
ID31427191Published Date2019-11-01JournalOral and maxillofacial surgery clinics of North America, 2019-11-01, Volume 31
Microvascular free tissue transfer has revolutionized the reconstruction of complex maxillofacial defects. These cases often necessitate a 2-teamed approach, with an ablative surgeon at the head and a reconstructive surgeon at a distant site for flap harvest. Careful attention to recipient vessel identification and preservation establishes the foundation for successful reconstruction. This article describes the surgical landmarks of the frequently utilized arteries and veins, vessel handling …
Publication
ID31653291Published Date2019-11-01JournalThe Annals of thoracic surgery, 2019-11-01, Volume 108
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