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ID32272315Published Date2020-07-15JournalJournal of colloid and interface science, 2020-07-15, Volume 572
Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures. In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.Alginate-nanohydroxyapatite interaction was studied by rheology and infrared spectroscopy measurements. The membranes were characterized regarding their tensile strength, degradation and s…
Publication
ID32222605Published Date2020-07-15JournalJournal of colloid and interface science, 2020-07-15, Volume 572
Protein aggregation plays important roles in life science as, for instance, those associated to neurodegenerative diseases. Although extensive efforts have been done to elucidate all the possible variables related to the aggregation process, much has yet to be done to unveil the main pathways governing protein assembling. In the current work, we induce bovine serum albumin (BSA) association, at pH 3.7, by adding sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) surfactants to …
Publication
ID32315907Published Date2020-07-20JournalThe Science of the total environment, 2020-07-20, Volume 727
In view of the current situation regarding the Covid-19 disease, a discussion is proposed on the need for research focusing on the presence and evolution of the SARS-CoV-2 virus in water, soils and other environmental compartments, reached through wastewater and sewage sludge spreading. Also, the evaluation of current treatments for wastewater and sewage sludge, as well as the eventual development of new specific techniques, based on sorption, nanotechnology, etc., would be of great interest …
Publication
ID32272302Published Date2020-07-01JournalBiomaterials, 2020-07-01, Volume 247
Gene-activated matrices (GAMs) encoding pivotal transcription factors (TFs) represent a powerful tool to direct stem cell specification for tissue engineering applications. However, current TF-based GAMs activated with pDNA, are challenged by their low transfection efficiency and delayed transgene expression. Here, we report a GAM technology activated with mRNAs encoding TFs SOX9 (cartilage) and MYOD (muscle). We find that these mRNA-GAMs induce a higher and faster TF expression compared to p…
Publication
ID32417266Published Date2020-07-01JournalActa biomaterialia, 2020-07-01, Volume 110
Gene delivery within hydrogel matrices can potentially direct mesenchymal stem cells (MSCs) towards a chondrogenic fate to promote regeneration of cartilage. Here, we investigated whether the mechanical properties of the hydrogel containing the gene delivery systems could enhance transfection and chondrogenic programming of primary human bone marrow-derived MSCs. We developed collagen-I-alginate interpenetrating polymer network hydrogels with tunable stiffness and adhesion properties. The hyd…
Publication
ID30739485Published Date2020-07-01JournalAging & mental health, 2020-07-01, Volume 24
Despite the importance of resilience in well-being and adaptation to the role of caregiver in non-professional caregivers, research on resilience in this population has been scarce and contradictory, and has methodological limitations. The objective of this study was to identify subgroups of caregivers with high levels of resilience based on a series of predictors including sociodemographic variables and variables related to care and personal and social development. 294 non-professional careg…
Publication
ID31863823Published Date2020-07-01JournalBrain, behavior, and immunity, 2020-07-01, Volume 87
Overactivity of the angiotensin-type-1 receptor (AT1)/NADPH-oxidase axis enhances aging processes, neuroinflammation and neurodegeneration. The role of AT2 receptors in the above-mentioned AT1-related effects in the aged brain, particularly substantia nigra, was investigated in this study. In the nigra, we observed a progressive decrease in AT2 mRNA expression with aging, and AT2 deletion led to changes in spontaneous motor behavior, dopamine receptors, renin-angiotensin system, and pro-oxida…
Publication
ID32145383Published Date2020-07-01JournalAnnals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2020-07-01, Volume 230
Growth hormone and prolactin secretion is affected by thyroid hormones. To see if this influence is subsidiary to the hyptothalamus, we investigated the effects of thyroxin (T4) on hormone secretion and histology of sellar pituitaries and pituitary grafts detached from the hypothalamus (autografted or allografted under the kidney capsule).Male Wistar rats were divided into eight groups: control, thyroidectomised, pituitary autografted, pituitary allografted, and four additional groups that we…
Publication
ID32600343Published Date2020-06-29JournalBMC health services research, 2020-06-29, Volume 20
Off-label drug use among ambulatory patients is often based on little or no scientific support. This paper reports the impact of a health warning about the risks of off-label flutamide use by women and the actions subsequently implemented by the public health service targeting such use.The study was undertaken in a region in north-west Spain. We designed a segmented regression model of an interrupted time series, in which the dependent variable was the monthly value of defined daily doses of …
Publication
IDDOI:10.1177/0734242x20935180Published Date2020-06-27JournalWaste Management & Research, 2020-06-27
The research and application of biochars enriched with minerals have increased in recent years; however, the mineral fraction used consists of specific minerals, such as clay minerals and synthesized compounds. In this work, the effects of adding two specific soil types (sandy and clayey) to rice and coffee husks in order to generate biochars via pyrolysis was investigated. Chemical, physical–chemical, thermal, spectroscopic and crystallographic analyses were conducted on the produced biochar…
We found 6,213 documents that match your Search
Research Grants: 299
Publications: 5,682
Patents: 199
Clinical Trials: 33

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