4079
4079
3928
3928
4228
4228
4191
4191
5399
5399
6090
6090
7100
7100
6760
6760
7184
7184
4465
4465
2019
2010
University (115.8K)Research Institution (8.5K)Hospital (7.3K)Company (1.5K)Other (1.2K)Foundation (1K)organization (82)Investor (37)
1 - 10 of 115,817
Sort by
Publication
ID31154976Published Date2019-07-22JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019-07-22, Volume 374
Abstract not available
Research Grant
Award Number1918243Funding AgencyNational Science FoundationEffective Date2019-07-15Expiration Date2021-08-31Funding Amount$75,000
Overweight and obesity (OO) are a huge public health concern in many countries. Globally, the prevalence of obesity has nearly doubled since 1980. One population at increased risk for OO is immigrants. However, we still have a limited understanding of how exposures to stressors over the migration process interact with the life course to impact risk for OO. OO increases risks for chronic diseases and the economic cost of obesity-related illnesses is estimated at $190.2 billion annually in the …
Publication
ID30951193Published Date2019-07-15JournalCancer, 2019-07-15, Volume 125
In a prior open-label study, the combination of dalantercept, a novel antiangiogenic targeting activin receptor-like kinase 1 (ALK1), plus axitinib was deemed safe and tolerable with a promising efficacy signal in patients with advanced renal cell carcinoma (RCC).In the current phase 2, randomized, double-blind, placebo-controlled study, patients with clear cell RCC previously treated with 1 prior angiogenesis inhibitor were randomized 1:1 to receive axitinib plus dalantercept versus axitinib…
Research Grant
Award Number1930288Funding AgencyNational Science FoundationEffective Date2019-07-15Expiration Date2020-12-31Funding Amount$20,601
Researchers have long sought to understand the emergence and development of the distinctive pastoral ways of life characteristic of central Eurasia. Many inhabitants of this enormous territory have been sustained for thousands of years by herding sheep, goats, cattle, and horses. The animal herds must be moved continually to fresh pastures in a pattern that often precludes the establishment of permanent residences. The relationship of such subsistence systems to sedentary agriculture or to hi…
Research Grant
Award Number1906368Funding AgencyNational Science FoundationEffective Date2019-07-15Expiration Date2023-06-30Funding Amount$400,212
As part of its overall strategy to enhance learning in informal environments, the Advancing Informal STEM Learning (AISL) program funds innovative research, approaches and resources for use in a variety of settings. This collaborative project will facilitate rural community education on climate impacts. The Carnegie Natural History Museum and the University of Pittsburgh will work together to form a network of interested community members in Mercer County and Powdermill Nature Reserve in west…
Publication
ID31100495Published Date2019-07-15JournalMolecular and cellular endocrinology, 2019-07-15, Volume 492
Human growth hormone (GH) binds and activates GH receptor (GHR) and prolactin (PRL) receptor (PRLR). LNCaP human prostate cancer cells express only GHR. A soluble fragment of IGF-1 receptor (IGF-1R) extracellular domain (sol IGF-1R) interacts with GHR and blocks GH signaling. We now explore sol IGF-1R's specificity for inhibiting GH signaling via GHR vs. PRLR and test GHR and PRLR extracellular domain inhibition determinants. Although T47D human breast cancer cells express GHR and PRLR, GH si…
Publication
ID31293189Published Date2019-07-11JournalExpert review of clinical immunology, 2019-07-11
: Neonates are less responsive to vaccines than adults, making it harder to protect newborns against infection. Neonatal differences in antigen presenting cell, B and T cell function, all likely contribute. A key question is whether novel adjuvants might be able to make neonatal vaccines more effective. : This review addresses the issues of how to improve neonatal vaccines, which we have defined as vaccines given in the first 4 weeks of life in a human infant or the first week of life in a mo…
Patent
Publication NumberUS 20190210969StatusPatent ApplicationAvailabilityUnknownFiling Date2019-01-04Publication Date2019-07-11
Provided herein are compositions and related methods useful for prevention or mitigation of ionizing radiation-induced esophagitis. The compositions comprise compounds comprising a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent or mitigate esophageal damage caused by ra…
Publication
ID31292299Published Date2019-07-11JournalJCI insight, 2019-07-11, Volume 4
Oncolytic viruses induce local tumor destruction and inflammation. Whether virotherapy can also overcome immunosuppression in noninfected tumor areas is under debate. To address this question, we have explored immunologic effects of oncolytic herpes simplex viruses (oHSVs) in a genetically engineered mouse model of isocitrate dehydrogenase (IDH) wild-type glioblastoma, the most common and most malignant primary brain tumor in adults. Our model recapitulates the genomics, the diffuse infiltrat…
Publication
ID31294748Published Date2019-07-11JournalJournal of biomechanical engineering, 2019-07-11
Endovascular coil embolization is widely used to treat cerebral aneurysms as an alternative to surgical clipping. It involves filling the aneurysmal sac with metallic coils to promote the formation of a coil/thrombus mass (CTM) to protect the aneurysm wall from hemodynamic forces and prevents rupture. A significant number of aneurysms are incompletely coiled leading to aneurysm regrowth and/or recanalization. Porcine blood and platinum coils were used to construct an in-vitro CTM for uniaxial…
We found 115,817 documents that match your Search
Research Grants: 37,292
Publications: 68,666
Patents: 4,335
Clinical Trials: 2,480
Opportunities: 820
Web Documents: 2,224

Wellspring Search is the world's most comprehensive collection of enriched content about emerging and licensable technology innovations.


Already a member? Sign in