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Publication
ID31767462Published Date2020-02-24JournalVaccine, 2020-02-24, Volume 38
Correlates of protection (CoPs) are increasingly important in the development and licensure of vaccines. Although the study of CoPs was initially directed at identifying a single immune function that could explain vaccine efficacy, it has become increasingly clear that there are often multiple functions responsible for efficacy. This review is meant to supplement prior articles on the subject, illustrating both simple and complex CoPs.
Publication
ID31732156Published Date2020-02-22JournalJournal of chromatography. A, 2020-02-22, Volume 1613
An on-line high-performance liquid chromatography-diode-array-detector-electrospray ionization-ion-trap-time-of-flight-mass spectrometry-total antioxidant capacity detection (HPLC-DAD-ESI-IT-TOF-MS-TACD) system was applied for the identification and evaluation of antioxidants in Rosa chinensis Jacq., an edible flower in food industry and a widely used traditional Chinese medicine. With the help of this platform, the HPLC fingerprint, mass fragmentations, and sample activity profiles against 1…
Publication
ID31895757Published Date2020-03-01JournalNuclear medicine communications, 2020-03-01, Volume 41
The aim of this study was to compare the effect of intensive therapy [consisting of high-dose chemotherapy followed by autologous stem cell transplantation (HDC/ASCT)] and conventional standard-dose chemotherapy (CDC) on brain FDG uptake, as an indicator of glucose metabolism, in multiple myeloma patients.Twenty-four patients with newly diagnosed multiple myeloma were included. Sixteen patients received HDC/ASCT, including bortezomib-based induction therapy, and eight patients received CDC. F…
Publication
ID31837471Published Date2020-03-01JournalNeuroImage, 2020-03-01, Volume 208
Alzheimer's disease (AD) is a progressive and irreversible brain degenerative disorder. Mild cognitive impairment (MCI) is a clinical precursor of AD. Although some treatments can delay its progression, no effective cures are available for AD. Accurate early-stage diagnosis of AD is vital for the prevention and intervention of the disease progression. Hippocampus is one of the first affected brain regions in AD. To help AD diagnosis, the shape and volume of the hippocampus are often measured …
Publication
ID29438767Published Date2020-03-01JournalJournal of the American Academy of Dermatology, 2020-03-01, Volume 82
Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management.We now present results from a subsequent Delphi consensus to broaden the generalizability of the recommendations.A preliminary survey, based on the European Dermatology Forum and the European Academy of Dermatology and Venereology guidelines, was sent to a panel of international experts to determine the leve…
Publication
ID31821815Published Date2020-03-01JournalPhysiology & behavior, 2020-03-01, Volume 215
Phasic dopamine activity is evoked by reliable predictors of food reward and plays a role in cue-triggered, goal-directed behavior. While this important signal is modulated by physiological state (e.g. hunger, satiety), the mechanisms by which physiological state is integrated by dopamine neurons is only beginning to be elucidated. Activation of central receptors for glucagon-like peptide-1 (GLP-1R) via long-acting agonists (e.g., Exendin-4) suppresses food intake and food-directed motivated …
Publication
ID31393158Published Date2020-03-01JournalJournal of experimental psychology. General, 2020-03-01, Volume 149
How should we judge a soldier who is fighting for an unjust cause? Is such a soldier the moral equal of a soldier fighting for an opposing, just cause? According to traditional just war theory (Walzer, 2006), soldiers on either side of a war are moral equals, regardless of the justness of the cause for which they fight (the "principle of combatant equality"). According to revisionist just war theory, however, the justness of the soldiers' causes should inform moral judgments of their actions;…
Publication
ID32042351Published Date2020-03-01JournalApplied research in quality of life, 2020-03-01, Volume 15
This study identified associations between perceived neighborhood stress and adolescents' perceptions of life satisfaction. African American adolescents aged 13-18 (=1,658) from four matched, mid-sized cities in the northeastern and southeastern USA, completed a self-report questionnaire using an audio computer-assisted self-interview (ACASI). Analyses examined relationships between perceived neighborhood stress and perceived life satisfaction, while controlling for socioeconomic status (SES)…
Publication
ID31783245Published Date2020-03-01JournalAddictive behaviors, 2020-03-01, Volume 102
With medical advances, the life expectancy of people living with HIV/AIDS (PLWHA) has improved; however, tobacco use remains a prominent risk for mortality. Although studies have examined the efficacy of varenicline for treating smoking among PLWHA, the relationship between varenicline adherence and cessation and correlates of varenicline adherence remain under-studied.We conducted secondary analyses from a randomized placebo-controlled trial of varenicline for smoking among PLWHA, using data…
Publication
ID31651075Published Date2020-03-01JournalHuman brain mapping, 2020-03-01, Volume 41
Midlife metabolic and vascular risk factors (MVRFs) predict cognitive decline and dementia; however, these risk factors tend to overlap, and the mechanisms underlying their effects on cognitive performance are not well understood. This cross-sectional study investigates the contributions of MVRFs to regional cerebral blood flow (CBF) and verbal learning & memory among middle-aged adults. We used partial least squares (PLS) analysis to create latent risk factor profiles and examine their assoc…
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