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ID31221481Published Date2019-08-20JournalBiochemical and biophysical research communications, 2019-08-20, Volume 516
Reactive oxygen species (ROS) are believed to play an important role in the proinflammatory form of neuroinflammation. Therefore, the availability of a radiotracer labeled with a positron-emitting radionuclide that can measure levels of ROS in tissue could provide a valuable method for imaging neuroinflammation in vivo with the functional imaging technique positron emission tomography (PET). We previously reported the synthesis and in vivo evaluation of [F]ROStrace, a radiotracer for imaging …
Publication
ID30296563Published Date2019-08-15JournalNeuroImage, 2019-08-15, Volume 197
Abstract not available
Publication
ID31034738Published Date2019-08-15JournalHuman brain mapping, 2019-08-15, Volume 40
Medial temporal lobe (MTL) substructures are the earliest regions affected by neurofibrillary tangle pathology-and thus are promising biomarkers for Alzheimer's disease (AD). However, automatic segmentation of the MTL using only T1-weighted (T1w) magnetic resonance imaging (MRI) is challenging due to the large anatomical variability of the MTL cortex and the confound of the dura mater, which is commonly segmented as gray matter by state-of-the-art algorithms because they have similar intensit…
Publication
ID31042319Published Date2019-08-15JournalCancer, 2019-08-15, Volume 125
Breast cancer therapies are associated with a risk of cardiac dysfunction, most commonly defined by changes in left ventricular ejection fraction (LVEF). Recently, the authors identified 3 classes of LVEF change after exposure to anthracyclines and/or trastuzumab using latent class growth modeling. The objective of the current study was to characterize the clinical, biochemical, and functional profiles associated with LVEF trajectory class membership.Transthoracic echocardiography and biomark…
Publication
ID31075390Published Date2019-08-15JournalNeuroImage, 2019-08-15, Volume 197
The use of network control theory to analyze the organization of white matter fibers in the human brain has the potential to enable mechanistic theories of cognition, and to inform the development of novel diagnostics and treatments for neurological disease and psychiatric disorders (Gu et al., 2015). The recent article (Tu et al., 2018) aims to challenge several of the contributions of (Gu et al., 2015), and particularly the conclusions that brain networks are theoretically controllable from…
Publication
ID31051295Published Date2019-08-15JournalNeuroImage, 2019-08-15, Volume 197
Movement planning involves transforming the sensory signals into a command in motor coordinates. Surprisingly, the real-time dynamics of sensorimotor transformations at the whole brain level remain unknown, in part due to the spatiotemporal limitations of fMRI and neurophysiological recordings. Here, we used magnetoencephalography (MEG) during pro-/anti-wrist pointing to determine (1) the cortical areas involved in transforming visual signals into appropriate hand motor commands, and (2) how …
Publication
ID31081231Published Date2019-08-15JournalHuman brain mapping, 2019-08-15, Volume 40
Mismatch responses reflect neural mechanisms of early cognitive processing in the auditory domain. Disturbances of these mechanisms on multiple levels of neural processing may contribute to clinical symptoms in major depression (MD). A functional magnetic resonance imaging (fMRI) study was conducted to identify neurobiological foundations of altered mismatch processing in MD. Twenty-five patients with major depression and 25 matched healthy individuals completed an auditory mismatch paradigm …
Publication
ID31142667Published Date2019-08-15JournalJournal of virology, 2019-08-15, Volume 93
SUMMARYThere is currently no knowledge of how the emerging human pathogen Zika virus (ZIKV) interacts with the antiviral endoribonuclease L (RNase L) pathway during infection. Since activation of RNase L during infection typically limits virus production dramatically, we used CRISPR-Cas9 gene editing technology to knockout (KO) targeted host genes involved in the RNase L pathway to evaluate the effects of RNase L on ZIKV infection in human A549 cells. RNase L was activated in response to ZIKV…
Publication
ID31078856Published Date2019-08-15JournalThe Science of the total environment, 2019-08-15, Volume 678
Sea level rise and uncertainty in its projections pose a major challenge to flood risk management and adaptation investments in coastal mega cities. This study presents a comparative economic evaluation method for flood adaptation measures, which couples a cost-benefit analysis with the concept of adaptation pathways. Our approach accounts for uncertainty in sea level rise projections by allowing for flexibility of adaptation strategies over time. Our method is illustrated for Los Angeles Cou…
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