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Publication
ID31655770Published Date2019-12-01JournalEndocrinology and metabolism clinics of North America, 2019-12-01, Volume 48
Primary aldosteronism used to be considered a rare cause of secondary hypertension. However, accruing evidence indicates that primary aldosteronism is more common than previously recognized. The implications of this increased prevalence are important to public health because autonomous aldosterone production contributes to cardiovascular disease and can be treated in a targeted manner. This article focuses on clinical approaches for diagnosing primary aldosteronism more frequently and earlier…
Publication
IDIEEE:8894715Published Date2019-12-01JournalIEEE Transactions on Instrumentation and Measurement, 2019-12-01, Volume 68
Dear Readers, Another fantastic year for TIM comes to an end, and I am delighted to share with you both the great achievements of 2019 and the exciting plans ahead. As always, let us start with the most important aspect, which is the quality of our journal.
Publication
ID31390060Published Date2019-12-01JournalCancer, 2019-12-01, Volume 125
Fear of cancer recurrence (FCR) adversely affects quality of life. Cigarette smoking increases the risk of recurrence and may exacerbate FCR among survivors who smoke. FCR also may motivate quitting, but research on whether quitting reduces long-term survivors' FCR is lacking. Among long-term survivors of various cancers, the authors investigated relationships between quitting (vs smoking) and FCR, controlling for sociodemographic, cancer-related, and health-related variables.Data from the Am…
Publication
ID31463572Published Date2019-12-01JournalActa neuropathologica, 2019-12-01, Volume 138
MSTO1 encodes a cytosolic mitochondrial fusion protein, misato homolog 1 or MSTO1. While the full genotype-phenotype spectrum remains to be explored, pathogenic variants in MSTO1 have recently been reported in a small number of patients presenting with a phenotype of cerebellar ataxia, congenital muscle involvement with histologic findings ranging from myopathic to dystrophic and pigmentary retinopathy. The proposed underlying pathogenic mechanism of MSTO1-related disease is suggestive of imp…
Clinical Trial
Clinical Trial IDNCT04163042Start Date2019-12-01Completion Date2021-12-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Survival rates for cancer are increasing, resulting in more young adult cancer survivors living with lingering side effects. Physical activity has been shown to improve the quality and length of life in young adult cancer survivors; yet, few are active enough, and little is currently being done to promote physical activity in this population. Therefore, the purpose of this 3-arm pilot randomized controlled trial is to explore the feasibility and acceptability of a behavioural support interven…
Publication
ID29672409Published Date2019-12-01JournalAnnals of surgery, 2019-12-01, Volume 270
The aim of this study was to measure the association of preoperative anticholinergic exposure with length of stay (LOS) and other outcomes in older people having elective noncardiac surgery.Anticholinergic medications are associated with adverse events in nonsurgical populations; the association of anticholinergic medications with outcomes in elective surgery patients is poorly described.We conducted a retrospective, population-based cohort study using linked administrative data in Ontario, C…
Publication
ID31278584Published Date2019-12-01JournalEnvironmental geochemistry and health, 2019-12-01, Volume 41
Geophagy, the intentional consumption of earth materials, has been recorded in humans and other animals. It has been hypothesized that geophagy is an adaptive behavior, and that clay minerals commonly found in eaten soil can provide protection from toxins and/or supplement micronutrients. To test these hypotheses, we monitored chimpanzee geophagy using camera traps in four permanent sites at the Budongo Forest Reserve, Uganda, from October 2015-October 2016. We also collected plants, and soil…
Publication
ID31070086Published Date2019-12-01JournalChannels (Austin, Tex.), 2019-12-01, Volume 13
Neuromuscular disorders encompass a wide range of conditions often associated with a genetic component. In the present study, we report a patient with severe infantile-onset amyotrophy in whom two compound heterozygous variants in the gene CACNA1H encoding for Ca3.2 T-type calcium channels were identified. Functional analysis of Ca3.2 variants revealed several alterations of the gating properties of the channel that were in general consistent with a loss-of-channel function. Taken together, t…
Publication
ID31300974Published Date2019-12-01JournalFish physiology and biochemistry, 2019-12-01, Volume 45
Acute elevation of cortisol via activation of the hypothalamic-pituitary-interrenal (HPI) axis aids the fish in dealing with a stressor. However, chronic elevation of cortisol has detrimental effects and has been studied extensively in lab settings. However, data pertaining to wild teleosts are lacking. Here, we characterized the metabolic consequences of prolonged cortisol elevation (96 h) in wild-caught pumpkinseed (Lepomis gibbosus). Pumpkinseed were implanted with cocoa butter alone (sham…
Publication
ID31525825Published Date2019-12-01JournalClinical obesity, 2019-12-01, Volume 9
Although considerable research is being conducted with a view to improve outcomes for pregnant women with obesity and their babies, much of this research is compromised by the quality of outcome reporting. Our aim is to determine how outcomes have been reported and measured in obesity in pregnancy studies, as a first step towards developing a core outcome set to standardize outcome reporting in future trials. We conducted a systematic review of clinical trials and systematic reviews on obesit…
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