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Publication
ID32684131Published Date2020-08-07JournalPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2020-08-07, Volume 378
We analyse the behaviour of acoustic vortex beams interacting with rotating, fluid-saturated porous materials. Regions of the parameter space that exhibit distinct dynamical features are identified, with a focus on features that are relevant to the characterization of rotational superradiance. We discuss the similarities and differences between two recent proposals to observe acoustic superradiance with rotating, air-saturated sound absorbers. Finally, theoretical predictions for macroscopic …
Publication
ID32589696Published Date2020-08-07JournalBiomaterials science, 2020-08-07, Volume 8
Conductive polymers have been used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability and brittleness of these polymers hinder the fabrication of three-dimensional structures with desirable geometries. Moreover, their application in tissue engineering and regenerative medicine has been so far limited to excitable cells such as neurons and muscle cells. To enable their wider adoption in tissue engineering and…
Publication
ID32608144Published Date2020-08-01JournalPharmacology research & perspectives, 2020-08-01, Volume 8
α1-adrenoceptor antagonists are widely used for hypertension (eg, doxazosin) and benign prostatic hypertrophy (BPH, eg, tamsulosin). Some antidepressants and antipsychotics have been reported to have α1 affinity. This study examined 101 clinical drugs and laboratory compounds to build a comprehensive understanding of α1-adrenoceptor subtype affinity and selectivity. [3H]prazosin whole-cell binding was conducted in CHO cells stably expressing either the full-length human α1A, α1B, or α1D-adren…
Publication
ID32418901Published Date2020-08-01JournalBrain research bulletin, 2020-08-01, Volume 161
Calcium/Calmodulin-dependent kinase alpha (αCaMKII) has been shown to play an essential role in synaptic plasticity and in learning and memory in animal models. However, there is little evidence for an involvement in specific memories in humans. Here we tested the potential involvement of the αCaMKII coding gene CAMK2A in verbal logical memory in two Caucasian populations from Germany, in a sample of 209 elderly people with cognitive impairments and a sample of 142 healthy adults. The associa…
Clinical Trial
Clinical Trial IDNCT04476563Start Date2020-08-01Completion Date2023-08-01Study TypeObservationalStatusNot yet recruiting
In this multi-center prospective observational study, the investigators plan to identify the incidence and risk factors for checkpoint inhibitor-induced liver injury and characterize biochemical, genetic, immunological, and histological features associated with it.
Clinical Trial
Clinical Trial IDNCT04383054Start Date2020-08-01Completion Date2020-12-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Physical activity (PA) can help treat and prevent many physical and mental health conditions. However, many of the United Kingdom population do not meet the Department of Health's PA recommendations which is contributing to the high chronic disease burden in the UK population. Many patients who are admitted to acute medical wards have at least one co- morbidity. Inpatients on acute hospital wards do not routinely receive PA advice from healthcare staff. The investigators believe that patients…
Publication
ID32524353Published Date2020-08-01JournalBreast cancer research and treatment, 2020-08-01, Volume 182
BMI1, which is a major component of the polycomb group complex 1, is an essential epigenetic repressor of multiple regulatory genes and has been identified as a cancer stem cell (CSC) marker in several cancers. However, its role in breast cancer (BC) remains to be defined. In this study, we have evaluated the prognostic significance of BMI1 among the different molecular subtypes and assessed its association with other breast CSC markers (BCSC).BMI1 copy number and mRNA was assessed in large a…
Publication
ID32460171Published Date2020-08-01JournalVision research, 2020-08-01, Volume 173
The adult visual system was traditionally thought to be relatively hard-wired, but recent studies have challenged this view by demonstrating plasticity following short-term monocular deprivation. Depriving one eye of spatial information for 2-3 h increased subsequent sensory dominance of that eye. However, the mechanism underlying this phenomenon is unclear. The present study sought to address this issue and determine the consequences of short-term monocular deprivation on inter-ocular suppre…
Publication
ID32112498Published Date2020-08-01JournalPest management science, 2020-08-01, Volume 76
Wireworms (larvae of the click beetle, Elateridae) are a significant agricultural pest, causing crop damage and reducing yields globally. Owing to the complex nature and opacity of the soil environment, research to investigate wireworm behaviour in situ has been scarce. X-ray computed tomography (CT) has previously been demonstrated as a powerful tool to independently visualise the 3D root system architecture, macroinvertebrate movement and distribution of burrow systems in soil, but not simu…
Publication
IDDOI:10.1177/0271678x19870770Published Date2020-08-01JournalJournal of Cerebral Blood Flow & Metabolism, 2020-08-01, Volume 40
The risk of cognitive decline and stroke is increased by atrial fibrillation (AF). We sought to determine whether neurovascular coupling and cerebral autoregulation are blunted in people with AF in comparison with age-matched, patients with hypertension and healthy controls. Neurovascular coupling was assessed using five cycles of visual stimulation for 30 s followed by 30 s with both eyes-closed. Cerebral autoregulation was examined using a sit–stand test, and a repeated squat-to-stand (0.1 …
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Research Grants: 4,946
Publications: 42,738
Patents: 462
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