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Publication
ID31669203Published Date2020-01-28JournalCancer letters, 2020-01-28, Volume 469
PARP1 inhibitor (Niraparib, Olaparib, Rucaparib) maintenance therapy improves progression-free survival in platinum sensitive sporadic epithelial ovarian cancers. However, biomarkers of response to PARPi therapy is yet to be clearly defined. XRCC1, a scaffolding protein, interacts with PARP1 during BER and SSBR. In a large clinical cohort of 525 sporadic ovarian cancers, high XRCC1 or high PARP1 protein levels was not only associated with aggressive phenotypes but was also significantly linke…
Publication
IDDOI:10.1115/1.4045037Published Date2020-02-01JournalJournal of Mechanisms and Robotics, 2020-02-01, Volume 12
Abstract Currently, flexible surfaces enabled to be actuated by robotic arms are experiencing high interest and demand for robotic applications in various areas such as healthcare, automotive, aerospace, and manufacturing. However, their design and control thus far has largely been based on “trial and error” methods requiring multiple trials and/or high levels of user specialization. Robust methods to realize flexible surfaces with the ability to deform into large curvatures therefore require…
Publication
IDDOI:10.1115/1.4044879Published Date2020-02-01JournalJournal of Tribology, 2020-02-01, Volume 142
Abstract A first-ever friction–wear model for four-ball extreme pressure (EP) lubrication is developed in this work based on 12 oil samples comprising minerals, esters, and other formulated lubricants. The model considers the rate of entropy generation and dissipation within the lubricated tribosystem to describe the interaction between the friction and the wear behaviors at extreme pressure conditions. The model can be used to calculate the probability to pass or fail at a specific load to e…
Publication
ID31734612Published Date2020-02-01JournalThe Science of the total environment, 2020-02-01, Volume 702
Wind energy has been considered as one of the greenest renewable energy sources over the last two decades. However, attention is turning to reducing the possible environmental impacts from this sector. We argue that wind energy would not be effectively "green" if anthropogenic materials are not given attention in a responsible manner. Using the concept of the circular economy, this paper considers how anthropogenic materials in the form of carbon fibers can reenter the circular economy system…
Publication
IDDOI:10.1177/1084822319876571Published Date2020-02-01JournalHome Health Care Management & Practice, 2020-02-01, Volume 32
This article reports on the use of an innovative reflective diary method with paid home care workers caring for people with dementia. It examines the key features of the diary design, recruitment and training of participants, diarists’ approaches and responses to diary-keeping, and evaluates the use of diaries in this context. Following training, 11 volunteers (all female) employed by a U.K.-based home care organization kept diaries of their experiences of caring for those with dementia. Usin…
Research Grant
Project ID224894Funding AgencyCommunity Research and Development Information ServiceEffective Date2020-02-01Expiration Date2024-01-31Funding Amount$4,570,025
Cancer is a major health burden responsible for 20% of European deaths. There is a critical need to understand its fundamental biological mechanisms. G protein-coupled receptors (GPCRs) are cell surface proteins which play an important role in regulating cellular functions integral to cancer biology and, as highly druggable proteins, oncogenic GPCRs are important therapeutic targets. ONCORNET2.0 builds on the success of ONCORNET (Oncogenic GPCR Network of Excellence and Training), a first-in-…
Publication
ID31628823Published Date2020-02-01JournalJournal of biomedical materials research. Part A, 2020-02-01, Volume 108
Cell-material interactions and compatibility are important aspects of bioactive materials for bone tissue engineering. Phosphate glass fiber (PGF) is an attractive inorganic filler with fibrous structure and tunable composition, which has been widely investigated as a bioactive filler for bone repair applications. However, the interaction of osteoblasts with PGFs has not been widely investigated to elucidate the osteogenic mechanism of PGFs. In this study, different concentrations of short PG…
Publication
IDIEEE:8733132Published Date2020-02-01JournalIEEE Transactions on Power Electronics, 2020-02-01, Volume 35
In this paper, a bidirectional dc–dc converter with coupled inductor is proposed. The proposed converter can achieve a wide voltage-gain range by turning the ratios of windings of the coupled inductor. Furthermore, the voltage stresses across the power switches are reduced. By employing a low-current ripple structure, a tiny input/output current ripple can be achieved, which can avoid larger filters. In addition, the common ground structure between the grounds of the input and the load sides …
Publication
ID31591909Published Date2020-02-01JournalAvian pathology : journal of the W.V.P.A, 2020-02-01, Volume 49
Chicken proventricular necrosis virus (CPNV) is a recently described birnavirus, which has been proposed to be the cause of transmissible viral proventriculitis (TVP). The understanding of the epidemiology of both the virus and the disease is very limited. A retrospective investigation on TVP and CPNV in broiler chicken submissions from the UK from between 1994 and 2015 was performed with the aims of assessing the longitudinal temporal evolution of TVP and CPNV, and to review the histological…
Publication
ID31054916Published Date2020-02-01JournalParasitology international, 2020-02-01, Volume 74
There is limited information regarding responses by slow cycling stem cells during T. spiralis-induced T-cell mediated intestinal inflammation and how such responses may relate to those of Paneth cells. Transgenic mice, in which doxycycline induces expression of histone 2B (H2B)-green fluorescent protein (GFP), were used. Following discontinuation of doxycycline ("chase" period), retention of H2B-GFP enabled the identification of slow cycling stem cells and long-lived Paneth cells. Inflammati…
We found 40,659 documents that match your Search
Research Grants: 993
Publications: 38,652
Patents: 455
Clinical Trials: 541
Web Documents: 18

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