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Patent
Publication NumberUS 10464977Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-04-11Publication Date2019-11-05
Provided herein are synthetic peptides or synthetic fragments thereof based on a Histatin-5 peptide, for example with a sequence DSHAKRHHGYKRKFHEKHHSHRGY (SEQ ID NO: 1). The synthetic peptides or synthetic fragments have at least one substituted amino acid that is arginine and/or leucine to increase resistance to proteolytic degradation by a microbe, such as a fungus. The synthetic peptides or synthetic fragments thereof may be contained in a hydrogel. Also provided are methods for treating o…
Patent
Publication NumberUS 10465223Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-10-09Publication Date2019-11-05
Methods for identifying fungal species by analysis of fungal membrane lipids, such as glycerophospholipids, sphingolipids and sterols, using mass spectrometry ionization patterns are disclosed.
Publication
ID31645163Published Date2019-11-05JournalJournal of the American Heart Association, 2019-11-05, Volume 8
Background Cardiac biomarkers may signal mechanistic pathways involved in heart failure (HF), a leading complication in chronic kidney disease. We tested the associations of NT-proBNP (N-terminal pro-B-type natriuretic peptide), high-sensitivity troponin T (hsTnT), galectin-3, growth differentiation factor-15 (GDF-15), and soluble ST2 (sST2) with incident HF in chronic kidney disease. Methods and Results We examined adults with chronic kidney disease enrolled in a prospective, multicenter stu…
Patent
Publication NumberUS 10463716Filing StatusIssued PatentAvailabilityUnknownFiling Date2015-10-13Publication Date2019-11-05
The present invention generally to methods of treating subjects suffering from a cardiac condition or having a risk factor for developing a cardiac condition by administering an ELA peptide or fusion protein to a subject in need. The invention relates to fusion proteins of Fc-ELA-32 and Fc-ELA-21 that exhibit improved properties for use as therapeutic agents, e.g. in the treatment of cardiac conditions. In addition, the present invention relates to polynucleotides encoding such fusion protein…
Clinical Trial
Clinical Trial IDNCT04150250Start Date2019-11-01Completion Date2020-08-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
A single-center, randomized, double-blind, placebo-controlled trial to assess safety and preliminary efficacy of oral doses of iOWH032 on diarrhea output and clinical symptoms after a cholera challenge. A total of 48 healthy adult individuals will be enrolled and challenged with a cholera strain before being randomized to either iOWH032 or placebo for 3 days.
Clinical Trial
Clinical Trial IDNCT04137809Start Date2019-11-01Completion Date2020-05-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Researchers at the University of Maryland Rehabilitation and Orthopaedic Institute are looking for individuals who have suffered a stroke and have leg and ankle weakness (foot-drop), to participate in a pilot study to examine the safety and effectiveness of an ankle robot walking program on walking function This is the first in human test of walking training over-ground using a wearable, lightweight, battery operated ankle robot exoskeleton; with assistance by trained research personnel for s…
Clinical Trial
Clinical Trial IDNCT04078022Start Date2019-11-01Completion Date2021-02-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to determine whether SF2a-TT15 (a monovalent synthetic carbohydrate-based conjugate Shigella vaccine) is safe and effective in the prevention of Shigella infection.
Clinical Trial
Clinical Trial IDNCT04034888Start Date2019-11-01Completion Date0030-05-30PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Exercise can be beneficial for older adults by promoting health, delaying or reversing functional decline, reducing chronic disease risk, decreasing falls, increasing strength and stamina, improving ability to perform activities of daily living (ADL), and improving overall quality of life (QOL). Developing and implementing exercise programs for homebound older adults for whom traveling to routine clinic-based appointments may not be feasible or safe becomes critical. Homebound, older adults a…
Publication
ID31451623Published Date2019-11-01JournalInfection and immunity, 2019-11-01, Volume 87
Invasive infections account for 15 to 50% of fatal bloodstream infections annually. These disseminated infections often arise without a defined portal of entry into the host but cause high rates of mortality. The fungus and the Gram-positive bacterium can form polymicrobial biofilms on epithelial tissue, facilitated by the adhesin encoded by While a bacterium-fungus interaction is required for systemic infection, the mechanism by which bacteria disseminate from the epithelium to internal orga…
Publication
ID31674214Published Date2019-11-01JournalBiomarkers in medicine, 2019-11-01
We externally validate plasma miRNAs biomarkers for lung cancer in a large and retrospective sample set collected from a geographically distant population. Plasma samples are tested blindly to the clinical annotations by using PCR for quantitation of the four miRNAs in cohort 1 consisting of 232 lung cancer cases and 243 controls and cohort 2 comprising 239 cases and 246 controls. Combined use of the four plasma miRNAs has 91% sensitivity and 95% specificity for diagnosis of lung cancer, and …
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