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ID31115088Published Date2019-08-30JournalStatistics in medicine, 2019-08-30, Volume 38
In epidemiological studies of secondary data sources, lack of accurate disease classifications often requires investigators to rely on diagnostic codes generated by physicians or hospital systems to identify case and control groups, resulting in a less-than-perfect assessment of the disease under investigation. Moreover, because of differences in coding practices by physicians, it is hard to determine the factors that affect the chance of an incorrectly assigned disease status. What results i…
Publication
ID31213295Published Date2019-08-20JournalBiochemical and biophysical research communications, 2019-08-20, Volume 516
There is a growing surge of investigative research involving the beneficial use of cannabinoids as novel interventional alternatives for multiple sclerosis (MS) and associated neuropathic pain (NPP). Using an experimental autoimmune encephalomyelitis (EAE) animal model of MS, we demonstrate the therapeutic effectiveness of two cannabinoid oil extract formulations (10:10 & 1:20 - tetrahydrocannabinol/cannabidiol) treatment. Our research findings confirm that cannabinoid treatment produces sign…
Publication
ID31048219Published Date2019-09-01JournalThe Journal of surgical research, 2019-09-01, Volume 241
Palliative care can improve end-of-life care and reduce health care expenditures, but the optimal timing for initiation remains unclear. We sought to characterize the association between timing of palliative care, in-hospital deaths, and health care costs.This is a retrospective cohort study including all patients who were diagnosed and died of colorectal cancer between 2004 and 2012 in Manitoba, Canada. The primary exposure was timing of palliative care, defined as no involvement, late invol…
Publication
ID31129411Published Date2019-09-01JournalChemosphere, 2019-09-01, Volume 231
Brominated flame-retardants are environmentally pervasive and persistent synthetic chemicals, some of which have been demonstrated to disrupt neuroendocrine signaling and electrical activity of neurons. 1,2-dibromo-4-(1,2-dibromoethyl)-cyclohexane (TBECH) lacks the toxicity of other classes of BFRs, however its safety is still questioned, as little is known of its neurological effects. Therefore, we sought to determine if TBECH could acutely alter the electrical activity of Purkinje neurons m…
Publication
ID31102787Published Date2019-09-01JournalBiochimica et biophysica acta. Molecular basis of disease, 2019-09-01, Volume 1865
Reactive oxygen species (ROS) are capable of inducing cell death or apoptosis. Recently, we demonstrated that lipid-ROS can mediate ferroptosis and activation of human platelets. Ferroptosis is an intracellular iron-mediated cell death, distinct from classical apoptosis and necrosis, which is mediated through the accumulation of ROS, lipid peroxides and depletion of cellular GSH. Lately, we demonstrated that hemoglobin degradation product hemin induces ferroptosis in platelets via ROS and lip…
Publication
ID31207282Published Date2019-09-01JournalComparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2019-09-01, Volume 235
The physiological consequences of exposing marine organisms to predicted future ocean scenarios, i.e. simultaneous increase in temperature and pCO, have only recently begun to be investigated. Adult American lobster (Homarus americanus) were exposed to either current (16 °C, 47 Pa pCO, pH 8.10) or predicted year 2300 (20 °C, 948 Pa pCO, pH 7.10) ocean parameters for 14-16 days prior to assessing physiological changes in their hemolymph parameters as well as whole animal ammonia excretion and …
Publication
ID31305275Published Date2019-09-01JournalCurrent opinion in urology, 2019-09-01, Volume 29
To review the evidence related to cytoreductive nephrectomy in metastatic renal cell carcinoma (mRCC) treated in the targeted therapy era, with a focus on observational studies and randomized trials.A number of retrospective observational studies exploring the role of cytoreductive nephrectomy have been reported. These have suggested an association between cytoreductive nephrectomy and survival, with hazard ratio estimates ranging from 0.39 to 0.68 in favour of cytoreductive nephrectomy. In c…
Publication
ID30982700Published Date2019-09-01JournalPatient education and counseling, 2019-09-01, Volume 102
We assessed the information needs of persons with any of three immune-mediated inflammatory diseases (multiple sclerosis [MS], inflammatory bowel disease [IBD] and rheumatoid arthritis [RA]) regarding depression, as a first step toward developing patient-relevant information resources, ultimately to facilitate self-management and appropriate care. We also compared information needs across genders.We surveyed participants with MS, IBD and RA regarding depression-related information needs inclu…
Publication
ID31284956Published Date2019-09-01JournalFood research international (Ottawa, Ont.), 2019-09-01, Volume 123
Multivariate data analysis feasibility for the evaluation of Brazilian stingless bee honey (SBH) by pollen spectrum, bioactive compounds content, physicochemical, antioxidant and antimicrobial analysis was investigated. Levels of total and individual phenolics content were analyzed by HPLC-PDA. The antioxidant capacity was performed by 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH), oxygen radical absorption capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays. The total phe…
Publication
ID31150959Published Date2019-09-01JournalSolid state nuclear magnetic resonance, 2019-09-01, Volume 101
The structural and electronic properties of solid coordination compounds are of great interest in a wide variety of applications. The sensitivity of solid-state NMR to local structural environments in the presence of a transition metal with unpaired spins is demonstrated through C and H MAS NMR spectra of tris(acetylacetonato)manganese (III), Mn(acac). The spectral assignment is established using a combination of density-functional theory and experimental NMR methods. An analysis of the spin-…
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