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Research Grant
Project Number5R01DK109382-04Funding AgencyNational Institutes of HealthEffective Date2019-08-01Expiration Date2020-07-31Funding Amount$352,726
Abstract: Glycogen is a critical reserve of oxidizable fuel for brain neuron use during states of heightened activity or glucoprivation. Iatrogenic hypoglycemia is a recurring complication of obligatory meticulous control of insulin-dependent diabetes mellitus and poses a serious risk of neural injury. There is thus keen interest to maximize protection against harmful effects of hypoglycemia by cerebral glycogen. Our studies show that estradiol and hindbrain catecholamine neurotransmitter sig…
Research Grant
Award Number1828157Funding AgencyNational Science FoundationEffective Date2018-10-01Expiration Date2020-09-30Funding Amount$274,857
This Major Research Instrumentation award is for the acquisition of a compact, portable Doppler Wind Lidar system. Doppler Wind Lidars use an eye-safe laser to remotely sense characteristics of the atmospheric boundary layer, such as wind, turbulence, and aerosols. This system will enhance the research capabilities at the University of Louisiana-Monroe into important topics for public safety and human health, such as the initiation of thunderstorms and air quality. The instrument will also be…
Research Grant
Project Number1R15DK118515-01Funding AgencyNational Institutes of HealthEffective Date2018-09-20Expiration Date2021-09-19Funding Amount$352,500
One major pathogenic mechanism in obesity is aberrant endocrine signaling, which is exemplified by insulin resistance. Once insulin resistance develops in obesity, hyperlipidemia and hyperglycemia can result, which drives forward pathogenesis. During obesity, macrophages are known to modulate insulin sensitivity through the release of cytokines, among them Interleukin-6 (IL-6). IL-6 is a JAK/STAT ligand, which binds its receptor to activate Janus Kinase, which activates STAT transcription fac…
Research Grant
Project Number5R01DK109382-03Funding AgencyNational Institutes of HealthEffective Date2018-08-01Expiration Date2019-07-31Funding Amount$352,726
Abstract: Glycogen is a critical reserve of oxidizable fuel for brain neuron use during states of heightened activity or glucoprivation. Iatrogenic hypoglycemia is a recurring complication of obligatory meticulous control of insulin-dependent diabetes mellitus and poses a serious risk of neural injury. There is thus keen interest to maximize protection against harmful effects of hypoglycemia by cerebral glycogen. Our studies show that estradiol and hindbrain catecholamine neurotransmitter sig…
Patent
Publication NumberUS 9963486Filing StatusIssued PatentAvailabilityUnknownFiling Date2015-05-07Publication Date2018-05-08
Novel peptidomimetic compounds are disclosed, compounds that inhibit protein-protein interactions (PPI) of epidermal growth factor receptors (EGFR), also called human epidermal growth factor receptors (HERs), and that block signaling for cell growth in HER2-overexpressed cancers. The novel peptidomimetics specifically bind the HER2 protein, and thereby inhibit dimerization. The peptidomimetics disrupt both HER2-HER3 and EGFR-HER2 heterodimer formation. The peptidomimetics can be used in the t…
Patent
Publication NumberUS 9765115Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-03-30Publication Date2017-09-19
The chain of events that explains calcitonin receptor (CTR)-stimulated invasion and metastasis of prostate cancer cells was identified. The CTR-stimulated events depend on the interaction of CTR with the PDZ3 domain of ZO-1. Small peptides and small molecules were identified that inhibit this interaction. The small inhibitory peptides were synthesized and can be used to attenuate or inhibit metastasis in solid cancer tumors.
Patent
Publication NumberUS 20170216329Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2015-05-06Publication Date2017-08-03
Water-soluble, cell-permeable nanomicelles containing ceramides and a steviol glycoside, such as rubusoside, are disclosed. The ceramide-steviol glycoside complex has high water solubility, and can be used for treating cancers with p53 mutations. Preliminary results have shown that the Cer nanomicelles are effective in restoring p53 protein expression, and that they are functionally dominant over p53 mutants. The novel nanomicelles restore a wild-type phenotype, and have very low toxicity to …
Research Grant
Project Number5R01DK109382-02Funding AgencyNational Institutes of HealthEffective Date2017-08-01Expiration Date2018-07-31Funding Amount$352,726
Abstract: Glycogen is a critical reserve of oxidizable fuel for brain neuron use during states of heightened activity or glucoprivation. Iatrogenic hypoglycemia is a recurring complication of obligatory meticulous control of insulin-dependent diabetes mellitus and poses a serious risk of neural injury. There is thus keen interest to maximize protection against harmful effects of hypoglycemia by cerebral glycogen. Our studies show that estradiol and hindbrain catecholamine neurotransmitter sig…
Research Grant
Project Number1R01DK109382-01A1Funding AgencyNational Institutes of HealthEffective Date2016-09-19Expiration Date2017-07-31Funding Amount$336,736
Abstract: Glycogen is a critical reserve of oxidizable fuel for brain neuron use during states of heightened activity or glucoprivation. Iatrogenic hypoglycemia is a recurring complication of obligatory meticulous control of insulin-dependent diabetes mellitus and poses a serious risk of neural injury. There is thus keen interest to maximize protection against harmful effects of hypoglycemia by cerebral glycogen. Our studies show that estradiol and hindbrain catecholamine neurotransmitter sig…
Research Grant
Project Number5R21HD083389-02Funding AgencyNational Institutes of HealthEffective Date2016-03-01Expiration Date2018-02-28Funding Amount$176,096
? DESCRIPTION (provided by applicant): Energy sufficiency is an essential requirement for optimal reproduction. Fertility is impaired in women and other female mammals when energy metabolism fails to meet bodily needs. Gonadotropin- releasing hormone (GnRH) neurons are repressed by energy shortage, but how metabolic control is asserted over this key neuroendocrine motor cell group is unclear. Our studies show that hindbrain neuroglucopenia is detected and signaled to GnRH cells by caudal dors…
We found 120 documents that match your Search
Research Grants: 109
Publications: 1
Patents: 9
Clinical Trials: 1

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