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Publication
ID31765609Published Date2020-02-15JournalDevelopmental biology, 2020-02-15, Volume 458
In this study, we investigated the role of the transcription factor Six2 in palate development. Six2 was selected using the SysFACE tool to predict genes from the 2p21 locus, a region associated with clefting in humans by GWAS, that are likely to be involved in palatogenesis. We functionally validated the predicted role of Six2 in palatogenesis by showing that 22% of Six2 null embryos develop cleft palate. Six2 contributes to palatogenesis by promoting mesenchymal cell proliferation and regul…
Publication
ID31602675Published Date2020-02-15JournalJournal of computational chemistry, 2020-02-15, Volume 41
G-protein-coupled receptors (GPCRs) are the largest family of human membrane proteins and serve as primary targets of approximately one-third of currently marketed drugs. In particular, adenosine A receptor (A AR) is an important therapeutic target for treating cardiac ischemia-reperfusion injuries, neuropathic pain, and renal diseases. As a prototypical GPCR, the A AR is located within a phospholipid membrane bilayer and transmits cellular signals by changing between different conformational…
Publication
ID31524819Published Date2020-02-15JournalSpine, 2020-02-15, Volume 45
Propensity score matched analysis of a multi-center prospective adult spinal deformity (ASD) database.Evaluate if surgical implant prophylaxis combined with avoidance of sagittal overcorrection more effectively prevents proximal junctional failure (PJF) than use of surgical implants alone.PJF is a severe form of proximal junctional kyphosis (PJK). Efforts to prevent PJF have focused on use of surgical implants. Less information exists on avoidance of overcorrection of age-adjusted sagittal al…
Publication
ID31846054Published Date2020-02-15JournalCancer, 2020-02-15, Volume 126
Patients with cancer-related pain are underrepresented in the opioid literature despite high opioid exposure and numerous risk factors for adverse opioid outcomes, including unnecessary persistent opioid use. The objective of this study was to determine the extent, historical trends, and predictors of new-onset persistent opioid use among older adult women after active breast cancer treatment.Using Surveillance, Epidemiology, and End Results-Medicare data for opioid-naive women diagnosed with…
Publication
ID31911050Published Date2020-02-13JournalJournal of biomechanics, 2020-02-13, Volume 100
Spinal intervertebral joints are complex structures allowing motion in multiple directions, and many experimental studies have reported moment-rotation response. However, experimental methods, reporting of results, and levels of the spine tested vary widely, and a comprehensive assessment of moment-rotation response across all levels of the spine is lacking. This review aims to characterize moment-rotation response in a consistent manner for all levels of the human spine. A literature search …
Publication
ID31927996Published Date2020-02-12JournalJournal of the American Chemical Society, 2020-02-12, Volume 142
Capture and activation of the water-soluble uranyl dication (UO) remains a challenging problem, as few rational approaches are available for modulating the reactivity of this species. Here, we report the divergent synthesis of heterobimetallic complexes in which UO is held in close proximity to a range of redox-inactive metals by a tailored macrocyclic ligand. Crystallographic and spectroscopic studies confirm assembly of homologous U(μ-O)M cores with a range of mono-, di-, and trivalent Lewi…
Publication
ID31436294Published Date2020-02-12JournalBiology of reproduction, 2020-02-12, Volume 102
Radiation induces ovarian damage and accelerates reproductive aging. Inbred mouse strains exhibit differential sensitivity to lethality induced by total body irradiation (TBI), with the BALB/cAnNCrl (BALB/c) strain being more sensitive than the 129S2/SvPasCrl (129) strain. However, whether TBI-induced ovarian damage follows a similar pattern of strain sensitivity is unknown. To examine this possibility, female BALB/c and 129 mice were exposed to a single dose of 1 Gy (cesium-137 γ) TBI at 5 w…
Publication
ID32045220Published Date2020-02-11JournalInorganic chemistry, 2020-02-11
The addition of Sc(OTf) and Al(OTf) to the mononuclear Mn-hydroxo complex [Mn(OH)(dpaq)] () gives rise to new intermediates with spectroscopic properties and chemical reactivity distinct from those of [Mn(OH)(dpaq)]. The electronic absorption spectra of [Mn(OH)(dpaq)] in the presence of Sc(OTf) (-Sc) and Al(OTf) (-Al) show modest perturbations in electronic transition energies, consistent with moderate changes in the Mn geometry. A comparison of H NMR data for and -Sc confirm this conclusion,…
Publication
ID31990562Published Date2020-02-11JournalMolecular pharmaceutics, 2020-02-11
Water has a critical role in the stability of the higher-order structure of proteins. In addition, it is considered to be a major destabilization factor for the physical and chemical stability of freeze-dried proteins and peptides. Physical and chemical aspects of protein/water relationships are commonly studied with the use of water vapor sorption isotherms for amorphous lyophilized proteins, which, in turn, are commonly analyzed using the Brunauer-Emmett-Teller (BET) equation to obtain the …
Publication
ID32048019Published Date2020-02-11JournalSurgical endoscopy, 2020-02-11
In patients with acute cholecystitis who are deemed high risk for cholecystectomy, percutaneous cholecystostomy (PC) was historically performed for gallbladder drainage (GBD). There are several limitations associated with PC. Endoscopic GBD [Endoscopic transpapillary GBD (ET-GBD) and EUS-guided GBD (EUS-GBD)] is an alternative to PC. We performed a systematic review and meta-analysis to compare the effectiveness and safety of EUS-GBD versus ET-GBD.We performed a systematic search of multiple …
We found 52,479 documents that match your Search
Research Grants: 11,152
Publications: 38,238
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