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ID31348055Published Date2020-04-01JournalAnesthesia and analgesia, 2020-04-01, Volume 130
There is a need for easy to use, reliable neuromuscular monitors (NMMs). This multicenter, prospective, unblinded study compared the discomfort associated with neurostimulation in unmedicated healthy volunteers when using the new electromyography (EMG)-based TetraGraph and acceleromyography (AMG)-based TOF-Watch NMMs. The secondary aim was to compare the repeatability of the train-of-four (TOF) ratios (TOFRs) obtained with the 2 devices.The TOF measurements of 135 volunteers from 3 university…
Publication
ID32101782Published Date2020-04-01JournalEuropean journal of medicinal chemistry, 2020-04-01, Volume 191
The endophytic fungus Cladosporium sphaerospermum WBS017 was obtained from healthy bulbs of Fritillaria unibracteata var. wabuensis. Fermentation of C. sphaerospermum on solid rice medium yielded three new hybrid polyketides, cladosins L-N (1-3), and a known derivative cladodionen (4). Further cultivation of this fungus on white bean medium afforded an additional new hybrid polyketide, cladosin O (5) along with three known analogues (6-8). The structures of the new compounds were elucidated u…
Publication
ID31918058Published Date2020-04-01JournalBioelectrochemistry (Amsterdam, Netherlands), 2020-04-01, Volume 132
Dysregulation of the cardiac ryanodine receptor (RYR2) by luminal Ca has been implicated in a life-threatening, stress-induced arrhythmogenic disease. The mechanism of luminal Ca-mediated RYR2 regulation is under debate, and it has been attributed to Ca binding on the cytosolic face (the Ca feedthrough mechanism) and/or the luminal face of the RYR2 channel (the true luminal mechanism). The molecular nature and location of the luminal Ca site is unclear. At the single-channel level, we directl…
Publication
ID31943428Published Date2020-04-01JournalMycoses, 2020-04-01, Volume 63
Candidaemia is a common life-threatening disease among hospitalised patients, but the effect of the Candida biofilm-forming ability on the clinical outcome remains controversial.The aim was to determine the impact of biofilms, specifically focusing on biofilm mass and metabolic activity, on the mortality in candidaemia.The clinical data of patients (n = 127) treated at the University of Debrecen, Clinical Centre, between January 2013 and December 2018, were investigated retrospectively. Biofi…
Publication
ID31987857Published Date2020-04-01JournalBiochemical pharmacology, 2020-04-01, Volume 174
Volatile anaesthetics (VAs) are the most widely used compounds to induce reversible loss of consciousness and maintain general anaesthesia during surgical interventions. Although the mechanism of their action is not yet fully understood, it is generally believed, that VAs depress central nervous system functions mainly through modulation of ion channels in the neuronal membrane, including 2-pore-domain K+ channels, GABA and NMDA receptors. Recent research also reported their action on nocicep…
Publication
ID32099881Published Date2020-04-01JournalData in brief, 2020-04-01, Volume 29
Soil survey is indispensable for land-use planning in any agro-ecosystem, particularly in coastal ecosystems because they often face several environmental problems such as flooding and water pollution, leading to soil degradation. The data given in this article revealing the common soil types and substantial taxonomy levels in the coastal region of Lattakia, Syria which is a key question for the land-use planning in the region. Data from 30 representative soil profiles and 60 auger points cov…
Publication
ID31951911Published Date2020-04-01JournalJournal of inorganic biochemistry, 2020-04-01, Volume 205
Based on our previous works involving two 1,4,7-triazacyclononane (tacn)-based ligands Hno2py1pa (1-Picolinic acid-4,7-bis(pyridin-2-ylmethyl)-1,4,7-triazacyclononane) and Hno1pa (1-Picolinic acid-1,4,7-triazacyclononane), we report here the synthesis of analogues bearing picolinate-based π-conjugated ILCT (Intra-Ligand Charge Transfer) transition antenna (HL1, HL2), using regiospecific N-functionalization of the tacn skeleton and their related transition metal complexes (e.g. Cu, Zn and Mn).…
Publication
ID31895105Published Date2020-04-01JournalCurrent opinion in obstetrics & gynecology, 2020-04-01, Volume 32
The aim of this systematic review is to summarize the current evidence regarding the effectiveness of hysterectomy and hysteroscopic endometrial resection in improving quality of life (QoL), sexual function and psychological wellbeing of women abnormal uterine bleeding.We performed a systematic literature search in PubMed/MEDLINE and Embase for original studies written in English (registered in PROSPERO 2019 CRD42019133632), using the terms 'endometrial ablation', 'endometrial destruction', '…
Publication
ID31881193Published Date2020-04-01JournalBiochemical pharmacology, 2020-04-01, Volume 174
Urotoxin (α-KTx 6), a peptide from venom of the Australian scorpion Urodacus yaschenkoi, is the most potent inhibitor of Kv1.2 described to date (IC = 160 pM). The native peptide also inhibits Kv1.1, Kv1.3 and KCa3.1 with nanomolar affinity but its low abundance in venom precluded further studies of its actions. Here we produced recombinant Urotoxin (rUro) and characterized the molecular determinants of Kv1 channel inhibition. The 3D structure of rUro determined using NMR spectroscopy reveale…
Publication
ID31555886Published Date2020-04-01JournalRheumatology international, 2020-04-01, Volume 40
We assessed cognitive function of female rheumatoid arthritis (RA) patients and analyze the determinants, with special focus on cerebrovascular morphology. Sixty methotrexate (MTX-) or biologic-treated RA patients and 39 healthy controls were included in a cross-sectional study. Smoking habits, alcohol intake and time spent in education were recorded. Standard measures were performed to assess cognitive function (Montreal Cognitive Assessment, MOCA; Trail Making Test, TMT; Victoria Stroop Tes…
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