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ID31756446Published Date2020-02-15JournalEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020-02-15, Volume 143
Nowadays, the sorbates are the third largest group of antimicrobial preservatives in food and pharmaceutical industries, following the parabens and benzoates whose safety is questioned by recent publications. A disadvantage of sorbates is their pH dependence, as their antimicrobial effect is greatly reduced in alkaline environment. The main, widely used sorbate derivatives are sorbic acid and potassium sorbate, no sorbic acid esters are involved in current industrial application. We aimed to …
Publication
ID32003765Published Date2020-02-14JournalPhysical chemistry chemical physics : PCCP, 2020-02-14, Volume 22
The absorption spectra of the cold Na molecule dressed by a linearly polarized standing laser wave is investigated with a theoretical model incorporating translational, electronic, vibrational as well as rotational degrees of freedom. In such a situation a light-induced conical intersection (LICI) can be formed (J. Phys. B: At. Mol. Opt. Phys., 2008, 41, 221001). To measure the spectra a weak field is used whose propagation direction is perpendicular to the direction of the dressing field but…
Publication
IDDOI:10.1093/forestry/cpz071Published Date2020-02-12JournalForestry: An International Journal of Forest Research, 2020-02-12
Abstract Most of the current understanding of the orientation and communication of jewel beetles arose from research on the Asian emerald ash borer (EAB), Agrilus planipennis, which has become one of the most destructive invasive forest insect pests in history following its introduction to North America and European Russia. From a European perspective, a number of jewel beetles have a high invasive risk similar to that of the emerald ash borer, including the potential threat of the bronze bir…
Publication
ID31935470Published Date2020-02-25JournalInternational journal of pharmaceutics, 2020-02-25, Volume 576
The cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays an important role in tumor development and formation of metastases. It was earlier reported that cyclodextrin derivatives have a high affinity to form complexes with PGE2. Based on these results radiolabeled cyclodextrins - as new radiopharmaceuticals - may open a new pathway in the in vivo imaging and diagnosis of PGE2 positive tumors. The aims of this study were to synthetize the PGE2 specific Ga-labeled NODAGA-randomly meth…
Publication
ID31767332Published Date2020-02-10JournalThe Science of the total environment, 2020-02-10, Volume 703
Cardamine violifolia (family Brassicaceae) is the first discovered selenium hyperaccumulator from the genus Cardamine with unique properties in terms of selenium accumulation, i.e., high abundance of selenolanthionine. In our study, a fully comprehensive experiment was conducted with the comparison of a non-hyperaccumulator Cardamine species, Cardamine pratensis, covering growth characteristics, chlorophyll fluorescence, spatial selenium/sulfur distribution patterns through elemental analyses…
Publication
ID31922157Published Date2020-02-07JournalOrganic & biomolecular chemistry, 2020-02-07, Volume 18
The design of glycogen phosphorylase (GP) inhibitors targeting the catalytic site of the enzyme is a promising strategy for a better control of hyperglycaemia in the context of type 2 diabetes. Glucopyranosylidene-spiro-heterocycles have been demonstrated as potent GP inhibitors, and more specifically spiro-oxathiazoles. A new synthetic route has now been elaborated through 1,3-dipolar cycloaddition of an aryl nitrile oxide to a glucono-thionolactone affording in one step the spiro-oxathiazol…
Publication
ID32046043Published Date2020-02-07JournalCells, 2020-02-07, Volume 9
Poly(ADP-Ribose) polymerases (PARPs) are enzymes that metabolize NAD. PARP1 and PARP10 were previously implicated in the regulation of autophagy. Here we showed that cytosolic electron-dense particles appear in the cytoplasm of C2C12 myoblasts in which PARP2 is silenced by shRNA. The cytosolic electron-dense bodies resemble autophagic vesicles and, in line with that, we observed an increased number of LC3-positive and Lysotracker-stained vesicles. Silencing of PARP2 did not influence the maxi…
Publication
ID32029456Published Date2020-02-06JournalGenes & development, 2020-02-06
Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating…
Publication
ID32041285Published Date2020-02-06JournalMolecules (Basel, Switzerland), 2020-02-06, Volume 25
Despite the substantial interest in -glycosyl heterocycles as mimetics of biologically active native glycans, the appearance of -glycopyranosyl derivatives of six-membered heterocycles, both in synthetic and biological contexts, is rather scarce. As part of our ongoing research program aimed at preparing hitherto barely known 2--glycopyranosyl pyrimidines, the goal of the present study was to synthesize new 5-mono- and multiply substituted derivatives of this compound class. Thus, 2--(β-D-glu…
Publication
ID31858209Published Date2020-03-01JournalRheumatology international, 2020-03-01, Volume 40
Increased cardiovascular (CV) morbidity and mortality have been found in rheumatoid arthritis (RA). Tumour necrosis factor α (TNF-α) inhibitors may improve vascular function. In the first part of this study, we determined microcirculation during postoocclusive reactive hyperemia (PORH) representing endothelial function. In a nonselected population (n = 46) we measured flow-mediated vasodilation (FMD) of the brachial artery and laser Doppler flow (LDF) by ultrasound. Among LDF parameters, we d…
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