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Publication
ID32439179Published Date2020-07-05JournalBiochemical and biophysical research communications, 2020-07-05, Volume 527
Patients with chronic kidney diseases have multiple cellular dysfunctions leading to increased atherosclerosis, impaired immunity, and disturbed metabolism. However, it is unclear what is the fundamental signaling served as a marker or as a mediator for the dysregulated function in their leukocytes or tissues. Here we hypothesized that the N-Methyladenosine (mA) modification of the RNA in the leukocytes is responsible for the cellular dysfunction in chronic kidney diseases. Patients with chro…
Publication
ID32320702Published Date2020-07-05JournalEuropean journal of pharmacology, 2020-07-05, Volume 878
This study investigated the effect of DAMGO-induced μ opioid receptor (MOR) internalization on morphine tolerance. Male Sprague-Dawley rats (200-250 g) aged 6-8 weeks were administered morphine via intrathecal (i.t.) injection (15 μg/10 μl twice daily for 6 days) to induce antinociceptive tolerance, which was evaluated using the tail-flick and paw-withdrawal tests. Response latency was calculated as the percentage of maximum possible effect (%MPE). A bolus of DAMGO was administered by i.t. in…
Publication
ID32420861Published Date2020-07-06JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020-07-06, Volume 375
Conspecific acceptance thresholds (Reeve 1989 , 407-435), which have been widely applied to explain ecological behaviour in animals, proposed how sensory information, prior information and the costs of decisions determine actions. Signal detection theory (Green & Swets 1966 ; SDT), which forms the basis of CAT models, has been widely used in psychological studies to partition the ability to discriminate sensory information from the action made as a result of it. In this article, we will revie…
Publication
ID32364583Published Date2020-07-06JournalThe Journal of cell biology, 2020-07-06, Volume 219
Through a genetic screen in zebrafish, we identified a mutant with disruption to myelin in both the CNS and PNS caused by a mutation in a previously uncharacterized gene, slc12a2b, predicted to encode a Na+, K+, and Cl- (NKCC) cotransporter, NKCC1b. slc12a2b/NKCC1b mutants exhibited a severe and progressive pathology in the PNS, characterized by dysmyelination and swelling of the periaxonal space at the axon-myelin interface. Cell-type-specific loss of slc12a2b/NKCC1b in either neurons or mye…
Publication
ID31850546Published Date2020-07-01JournalMagnetic resonance in medicine, 2020-07-01, Volume 84
Mesorectal lymph node staging plays an important role in treatment decision making. Here, we explore the benefit of higher-order diffusion MRI models accounting for non-Gaussian diffusion effects to classify mesorectal lymph nodes both 1) ex vivo at ultrahigh field correlated with histology and 2) in vivo in a clinical scanner upon patient staging.The preclinical investigation included 54 mesorectal lymph nodes, which were scanned at 16.4 T with an extensive diffusion MRI acquisition. Eight d…
Publication
ID30606078Published Date2020-07-01JournalThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020-07-01, Volume 33
The potential value of preconception care and interconception care is increasingly acknowledged, but delivery is generally uncommon. Reaching women for interconception care is potentially easier than for preconception care, however the concept is still unfamiliar. Expert consensus could facilitate guidelines, policies and subsequent implementation. A national and subsequent international expert meeting were organized to discuss the term, definition, content, relevant target groups, and ways t…
Publication
IDIEEE:8809896Published Date2020-07-01JournalIEEE Transactions on Industrial Electronics, 2020-07-01, Volume 67
Tray indexing driven by timing belt actuator is widely used in the industry, where high-precision profile tracking is essential to guarantee good production quality. To avoid humming sound and chip dislodged, an autonomous S-curve trajectory is used as the reference profile and the jerk resulting from the control input chattering needs to be well controlled. To implement the optimal tracking control with respect to an S-curve profile and maintain a guaranteed adequate level of performance tow…
Publication
ID32175616Published Date2020-07-01JournalChild: care, health and development, 2020-07-01, Volume 46
The number of refugees worldwide has increased in recent years, and with this, there has been an increase in the numbers of unaccompanied asylum-seeking minors (UASMs) in the UK. Refugees have been found to experience notable difficulties upon resettlement, and there is evidence to suggest that education can provide a supportive role for young refugees. Although there has been research that has found that UASMs value education, there has been less research that has directly looked at the expe…
Publication
ID32371620Published Date2020-07-01JournalCurrent opinion in cardiology, 2020-07-01, Volume 35
Vascular disease often affects more than one territory. Atherosclerosis is a global disease affecting multiple organs/systems. Cardiovascular risk factors are associated with an increased risk for the development of arterial disease in all vascular beds but differ in their individual impacts for each vascular bed. We discuss the various options to identify and manage multifocal arterial disease.Coronary artery disease may coexist with carotid artery stenosis, abdominal aortic aneurysms, and/o…
Publication
ID31446608Published Date2020-07-01JournalPathology oncology research : POR, 2020-07-01, Volume 26
Oral squamous cell carcinoma (OSCC) is the eight most common malignancy worldwide with an incidence rate of 40% in south-east Asia. Lack of effective diagnostic tools at early stage and disease recurrence despite extensive treatments are main reasons for high mortality and low survival rates. The aim of current study was to identify differentially expressed proteins to explore potential candidate biomarkers having diagnostic significance. We performed comparative proteomic analysis of paired …
We found 350,543 documents that match your Search
Research Grants: 876
Publications: 349,176
Patents: 374
Clinical Trials: 99
Web Documents: 18

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