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Research Grant
Award Number2004681Funding AgencyNational Science FoundationEffective Date2020-07-01Expiration Date2023-06-30Funding Amount$257,090
Currently patterns on metal surfaces can be fabricated with features in the nanometer (one billionth of a meter) size range. These patterns can interact strongly with particular colors of light. Fluorescent molecules are designed to give off certain colors of light, and are used to mark specific molecules and proteins in biological applications. A nanopatterned metal surface can be made such that its optical properties match a particular fluorescent molecule and enhance the light signal from …
Publication
IDDOI:10.1091/mbc.e18-09-0556Published Date2020-06-17JournalMolecular Biology of the Cell, 2020-06-17
Fig4 is a phosphoinositide phosphatase that converts PI3,5P2 to PI3P. Paradoxically, mutation of Fig4 results in lower PI3,5P2, indicating that Fig4 is also required for PI3,5P2 production. Fig4 promotes elevation of PI3,5P2, in part, through stabilization of a protein complex that includes its opposing lipid kinase, Fab1, and the scaffold protein Vac14. Here we show that multiple regions of Fig4 contribute to its roles in the elevation of PI3,5P2: its catalytic site, an N-terminal disease-re…
Publication
ID32488266Published Date2020-06-02JournalCerebral cortex (New York, N.Y. : 1991), 2020-06-02
Synapses are involved in the communication of information from one neuron to another. However, a systematic analysis of synapse density in the neocortex from a diversity of species is lacking, limiting what can be understood about the evolution of this fundamental aspect of brain structure. To address this, we quantified synapse density in supragranular layers II-III and infragranular layers V-VI from primary visual cortex and inferior temporal cortex in a sample of 25 species of primates, in…
Publication
ID32368578Published Date2020-06-01JournalData in brief, 2020-06-01, Volume 30
The structural conformations of phospholipids and cholesterol in phase-separated lipid domains were determined by surface area, transverse density profile, and lipid acyl chain orientational parameter calculations. Binding kinetics and characterization of membrane-bound states of beta-amyloid fibrils of various sizes (dimer to pentamer), on those lipid domains, were determined using protein residue orientational parameter and fibril-residue-lipid minimum distance analysis methods. The energy …
Publication
ID32410227Published Date2020-05-15JournalThe Journal of comparative neurology, 2020-05-15
This study reports an analysis of 20 T1-weighted magnetic resonance imaging scans from tufted capuchin monkeys (5 male, 15 female). We carried out a data-driven, whole-brain volumetric analysis on regional gray matter anatomy using voxel-based morphometry. This revealed that males showed statistically significant expansion of a region of the hypothalamus, while females showed significant expansion in a distributed set of regions, including the cerebellum, early visual cortex, and higher-order…
Publication
IDDOI:10.1139/cjfr-2019-0250Published Date2020-05-13JournalCanadian Journal of Forest Research, 2020-05-13
Using data from National Council of Real Estate Investment Fiduciaries (NCREIF), we examine market integration of commercial real estate and timberland/farmland assets via the Fama-MacBeth two-step approach under the intertemporal capital asset pricing framework. In addition, we study the information transition dynamics between those markets via the vector error correction model (VECM). We find evidence of market segregation and one-way information flow from the timberland/farmland market to …
Publication
ID32358999Published Date2020-05-02JournalAngewandte Chemie (International ed. in English), 2020-05-02
A mononuclear nonheme cobalt(III) iodosylbenzene complex, [Co (TQA)(OIPh)(OH)] (1), is synthesized and characterized structurally and spectroscopically. While 1 is a sluggish oxidant in oxidation reactions, it becomes a competent oxidant in oxygen atom transfer reactions, such as olefin epoxidation, in the presence of a small amount of proton. More interestingly, 1 shows a nucleophilic reactivity in aldehyde deformylation reaction, demonstrating that 1 has an amphoteric reactivity. Another in…
Publication
ID32179374Published Date2020-05-01JournalBiophysical chemistry, 2020-05-01, Volume 260
The membrane binding behaviors of beta-amyloid fibrils, dimers to pentamers, from solution to lipid raft surfaces, were investigated using coarse-grained (CG) MD simulations. Our CG rafts contain phospholipid, cholesterol (with or without tail- or headgroup modifications), and with or without asymmetrically distributed monosialotetrahexosylganglioside (GM1). All rafts exhibited liquid-ordered (Lo), liquid-disordered (Ld), and interfacial Lo/Ld (Lod) domains, with domain sizes depending on cho…
Publication
IDDOI:10.1177/1464884918775073Published Date2020-05-01JournalJournalism, 2020-05-01, Volume 21
This study explores journalists’ use of Twitter and what it means for their craft. Based on 8 weeks newsroom observation and more than a dozen in-depth interviews with reporters and editors at a big metro newspaper, the study found that journalists had contradicting views on whether or not to accept tweets, a form of snippet artifact, as a legitimate journalism artifact, leading to the blurring artifact boundary. Related, journalists faced uncertainties and ambiguities regarding the implicati…
Publication
ID32365059Published Date2020-05-01JournalPLoS neglected tropical diseases, 2020-05-01, Volume 14
Dengue is a highly endemic disease in Southeast Asia and is transmitted primarily by the mosquito, Aedes aegypti. The National Capital Region (NCR) of the Philippines, or Metropolitan Manila, is a highly urbanized area that is greatly affected by this arboviral disease. Urbanization has been shown to increase the dispersal of this mosquito vector. For this reason, we conducted a fine-scale population genetic study of Ae. aegypti in this region. We collected adult Ae. aegypti mosquitoes (n = 5…
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Research Grants: 299
Publications: 1,245
Patents: 4

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