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Research Grant
Project Number1R43DE024659-01Funding AgencyNational Institutes of HealthEffective Date2014-09-15Expiration Date2017-02-28Funding Amount$186,330
DESCRIPTION (provided by applicant): Summary Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. About 17.9 million adults have been diagnosed with cancer in the United States, which is ~7.9% of the total population. At least 40%, and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body radiation develop oral mucositis. To d…
Research Grant
Project Number1R41AR067106-01Funding AgencyNational Institutes of HealthEffective Date2014-09-01Expiration Date2016-08-31Funding Amount$194,672
DESCRIPTION (provided by applicant): Chronic skin wounds associated with various diseases (e.g., diabetes) and aberrant healing from acute wounding (e.g., hypertrophic scarring) is a major health care burden, which need scientific discovery-based therapeutic interventions. Our previous studies show that Smad7, a TGFb signaling antagonist, accelerates skin wound healing. We have developed a Smad7 fusion protein that contains the human Smad7 fused to the HIV-1 Tat protein transduction domain (P…
Research Grant
Project Number5R44HL091740-03Funding AgencyNational Institutes of HealthEffective Date2011-08-01Expiration Date2013-01-31Funding Amount$759,221
DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from primary mouse blood stem cells. Phase I of this project included applying this technology to generate human cell lines. In addition, the project included testing a non-viral method to generate the stem cell lines from mice. Phase II of the project will entail optimizing large-scale production of protein transd…
Research Grant
Project Number1R43HL104760-01Funding AgencyNational Institutes of HealthEffective Date2010-09-01Expiration Date2012-02-28Funding Amount$151,441
DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from primary human cord blood stem cells. Phase I of this project includes applying newly discovered non- viral technology to generate human cell lines and the subsequent differentiation of those cells into human red blood cells. In addition, the project includes testing the function of these cells in small animals…
Research Grant
Project Number2R44HL091740-02A1Funding AgencyNational Institutes of HealthEffective Date2010-08-01Expiration Date2011-07-31Funding Amount$660,642
DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from primary mouse blood stem cells. Phase I of this project included applying this technology to generate human cell lines. In addition, the project included testing a non-viral method to generate the stem cell lines from mice. Phase II of the project will entail optimizing large-scale production of protein transd…
Research Grant
Project Number1R43AI089307-01Funding AgencyNational Institutes of HealthEffective Date2010-03-01Expiration Date2011-08-31Funding Amount$171,767
DESCRIPTION (provided by applicant): Using a new approach to adjuvant design we have identified a molecular based adjuvant that enhances immune response by several criteria including, an earlier response, a stronger response to more parts of the vaccine, and the ability to respond to very small amounts of vaccine. Phase I of this project involves applying the same technology to HIV-1 antigens. Phase II of the project will entail optimizing large-scale production of our adjuvant for studies in…
Research Grant
Project Number1R43HL091740-01Funding AgencyNational Institutes of HealthEffective Date2008-09-19Expiration Date2010-09-18Funding Amount$161,192
[unreadable] DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from primary mouse bone marrow stem cells. Phase I of this project includes testing the same technology in human cells and the subsequent analysis of those cells in the laboratory and in mice. In addition, the project includes knockdown of HIV-1 co-receptors to generate HIV-1 resistant cells in a mouse…
Research Grant
Project Number1R43AI078563-01Funding AgencyNational Institutes of HealthEffective Date2008-08-15Expiration Date2010-07-31Funding Amount$180,667
[unreadable] DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from mouse bone marrow stem cells, fetal cord blood and adult bone marrow stem cells. Phase I of this project includes testing existing mouse antibodies against Influenza for their ability to neutralize pathogenic strains of Influenza and adapting this technology to generate human antibodies against In…
We found 8 documents that match your Search
Research Grants: 8
Patents: 89
Clinical Trials: 2
SEC Filings: 3

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