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Clinical Trial
Clinical Trial IDNCT02860559Start Date2020-08-01Completion Date2024-03-01PhasePhase 1Study TypeInterventionalStatusNot yet recruiting
This is a study of stem cell transplantation with TBX-1400 in pediatric subjects with severe combined immunodeficiency (SCID). The donor cells are exposed to a protein that has been shown in the laboratory to improve the ability of the donor cells to make blood and immune cells after transplant. Exposure of the donor cells to this protein does not modify the genes in the cells in any way. This study has two goals. The first goal is to find out if transplant with TBX-1400 is safe. The second g…
Patent
Publication NumberUS 20200148749Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-10-10Publication Date2020-05-14
Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments, provided herein are methods for rapidly producing antibody producing organisms, tissues, cells and antibodies derived from humans, organisms, plants or cells that are genetically altered to over-express certain proteins.
Patent
Publication NumberUS 10583156Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-12-01Publication Date2020-03-10
This present disclosure relates to methods and compositions comprising biologically active nanoparticle formulations of MYC protein. Provided are methods of making the nanoparticle formulations and methods of using the nanoparticle formulations for treatment.
Patent
Publication NumberUS 10556006Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-09-27Publication Date2020-02-11
Disclosed herein are methods of modulation of the viability of a cell using fusion proteins comprising a transporter peptide sequence and a MYC polypeptide. Further disclosed herein are methods of modulating an immune response using the fusion proteins. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immu…
Patent
Publication NumberJP 6647334 B2Filing StatusIssued PatentAvailabilityUnknownFiling Date2018-03-15Publication Date2020-01-16
Patent
Publication NumberAU 2014249200 B2Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-03-11Publication Date2020-01-16
The present disclosure relates to the production of red blood cells from hematopoietic stem cells, by differentiating such cells in the presence of a protein that induces cell survival and proliferation.
Patent
Publication NumberJP 2019178180 AFiling StatusPatent ApplicationAvailabilityUnknownFiling Date2019-07-29Publication Date2019-10-17
To provide methods for enhancing reconstitution of hematopoietic compartment in subjects in need of hematopoietic stem cell transplantation.SOLUTION: Disclosed herein is a method comprising: (a) a step of obtaining a group of hematopoietic stem cells treated with a composition comprising a MYC composition or a Bcl-2 composition or both for less than about 13 days; and (b) administering to the subject a therapeutically effective amount of the group of treated hematopoietic stem cells for recon…
Patent
Publication NumberUS 10442853Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-08-23Publication Date2019-10-15
Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments, provided herein are methods for rapidly producing antibody producing organisms, tissues, cells and antibodies derived from humans, organisms, plants or cells that are genetically altered to over-express certain proteins.
Patent
Publication NumberEP 3548425 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-12-01Publication Date2019-10-09
Patent
Publication NumberCN 110177758 AFiling StatusPatent ApplicationAvailabilityUnknownFiling Date2017-12-01Publication Date2019-08-27
This present disclosure relates to methods and compositions comprising biologically active nanoparticle formulations of MYC protein. Provided are methods of making the nanoparticle formulations and methods of using the nanoparticle formulations for treatment.
We found 138 documents that match your Search
Research Grants: 8
Patents: 124
Clinical Trials: 2
SEC Filings: 4

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