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Publication
ID31809265Published Date2020-02-25JournalJournal of pediatric endocrinology & metabolism : JPEM, 2020-02-25, Volume 33
Background Non-adherence to diabetes medication leads to poor outcomes and increased healthcare costs. Multiple factors affecting adherence in adults with type 2 diabetes (T2D) have been identified, but pediatric data is sparse. We aimed to determine whether initiation of additional oral medications or insulin affects adherence to primary study medication (PSM) in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study. Methods Six hundred and ninety-nine youth (aged …
Publication
ID31790782Published Date2020-02-17JournalBehavioural brain research, 2020-02-17, Volume 380
The development of sensitization is one of the hallmarks of addictive drugs. Consistent with this relationship many studies have demonstrated that the highly addictive opioid agonist morphine induces sensitization effects. In this study, we administered morphine (10 mg/kg) (MOR) to induce sensitization. In that sensitization is considered to involve associative processes and that dopamine activity is an important contributor to learning and memory processes, we administered a dopamine inhibit…
Publication
ID31904688Published Date2020-03-01JournalThe Journal of cardiovascular nursing, 2020-03-01, Volume 35
Cardiovascular disease (CVD) is the leading cause of death in most countries. Lack of awareness of the impact CVD has on women is a continuing problem. Rural women are at a great risk for CVD and have specific barriers to early recognition and to access to treatment.The purpose of this systematic review was to identify how the state of the science for rural women and CVD has progressed over the last decade.Searches were conducted using the databases Cochrane, PubMed, and CINAHL with 5 major s…
Publication
ID31890599Published Date2020-03-01JournalUrology case reports, 2020-03-01, Volume 29
The testicular seminomas are germ-cell tumors which account for approximately 50% of all testicular tumors. Most primary testicular germ cell tumors metastasize through a lymphatic system in a predictable pattern with the retroperitoneal lymph nodes being the most common initial metastatic site. Hematological metastasis to the distant organs is less common, and except for pulmonary metastasis, changes the classification from good to intermediate prognosis. Metastasis of testicular seminoma to…
Publication
ID31821033Published Date2020-03-01JournalAdvances in physiology education, 2020-03-01, Volume 44
Medical students have difficulty understanding the mechanisms underlying hyperkalemia-mediated local control of blood flow. Such control mechanisms are crucial in the brain, kidney, and skeletal muscle vasculature. We aimed to identify medical students' misconceptions via assessment of students' in-class knowledge and, subsequently, improve future teaching of this concept. In-class polling was performed with the TurningPoint clicker response system ( = 860) to gauge students' understanding of…
Publication
ID31944845Published Date2020-03-01JournalAmerican journal of public health, 2020-03-01, Volume 110
The detention of immigrants inside US borders is not a new phenomenon. However, a dramatic shift has occurred in both the number and treatment of immigrants in detention.We examine recent changes in immigration policies that have systematized the mistreatment of children and pregnant immigrants, including a ban on abortion for unaccompanied minors in immigration detention, the neglect and mistreatment of pregnant immigrants in detention, and the separation and prolonged detention of parents a…
Publication
ID31739002Published Date2020-03-02JournalBehavioural brain research, 2020-03-02, Volume 381
Models of animal behavior suggest that anxiety and major depressive disorder (MDD) may be characterized by different profiles of escape and avoidance behavior. However, the literature on coping strategies fails to distinguish between avoidance and escape coping patterns, instead grouping escape behaviors into the larger category of avoidant coping. We argue that investigating both escape and avoidance coping behavior in those with anxiety and depression may reveal distinct behavioral profiles…
Publication
ID32049315Published Date2020-02-12JournalBiochemical Society transactions, 2020-02-12
Modulating the activity of the Src Homology 2 (SH2) - containing Inositol 5'-Phosphatase (SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional method of influencing cell signaling in the PI3K pathway. The development of small molecules that selectively target one of the SHIP paralogs (SHIP1 or SHIP2) as well as inhibitors that simultaneously target both enzymes have provided promising data linking the phosphatase activity of the SHIP enzymes to disorders and…
Publication
ID32046535Published Date2020-02-12JournalThe American journal of psychiatry, 2020-02-12
22q11.2 deletion syndrome (22q11DS) is among the strongest known genetic risk factors for schizophrenia. Previous studies have reported variable alterations in subcortical brain structures in 22q11DS. To better characterize subcortical alterations in 22q11DS, including modulating effects of clinical and genetic heterogeneity, the authors studied a large multicenter neuroimaging cohort from the ENIGMA 22q11.2 Deletion Syndrome Working Group.Subcortical structures were measured using harmonized…
Publication
IDDOI:10.1042/bst20190775Published Date2020-02-12JournalBiochemical Society Transactions, 2020-02-12
Modulating the activity of the Src Homology 2 (SH2) — containing Inositol 5′-Phosphatase (SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional method of influencing cell signaling in the PI3K pathway. The development of small molecules that selectively target one of the SHIP paralogs (SHIP1 or SHIP2) as well as inhibitors that simultaneously target both enzymes have provided promising data linking the phosphatase activity of the SHIP enzymes to disorders and…
We found 11,434 documents that match your Search
Research Grants: 2,907
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