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ID32348953Published Date2020-07-15JournalJournal of pharmaceutical and biomedical analysis, 2020-07-15, Volume 186
Biogenic amines (BA) are a broad group of biologically active substances, the presence of which in the human body can provide important diagnostic information for many various pathologies, including chronic inflammation. In this work, a capillary electrophoresis (CE) hyphenated with tandem mass spectrometry (MS/MS) method was developed for the simultaneous determination of twelve BA (histamine, serotonin, dopamine, norepinephrine, epinephrine, putrescine, cadaverine, spermine, spermidine, tyr…
Publication
ID32057476Published Date2020-07-15JournalInternational journal of cardiology, 2020-07-15, Volume 311
Evidence is lacking on long-term outcomes in unselected patients surviving the first year following myocardial infarction (MI).The TIGRIS (long-Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients) prospective registry enrolled 9176 eligible patients aged ≥50 years, 1-3 years post-MI, from 25 countries. All had ≥1 risk factor: age ≥ 65 years, diabetes mellitus, second prior MI, multivessel coronary artery d…
Publication
ID32614240Published Date2020-07-02JournalAnnals of the American Thoracic Society, 2020-07-02
Diaphragm function is a key determinant of dyspnea in COPD; however, it is rarely assessed in clinical practice. Lung hyperinflation can also impair diaphragm function. Ultrasound can assess the activity, function and the force reserve of the diaphragm.To compare diaphragm activity, function, and force reserve among patients with COPD and in healthy controls.80 patients with stable COPD and 20 healthy controls were enrolled (97% of them were male). Ultrasound was used to measure the thickenin…
Publication
ID32613857Published Date2020-07-02JournalCanadian journal of psychiatry. Revue canadienne de psychiatrie, 2020-07-02
A variety of patient characteristics drive the use of electroconvulsive therapy (ECT) in depression. However, the extent to which each characteristic influences the receipt of ECT, and whether they are appropriate, is unknown. The aim of this study is to identify patient-level characteristics associated with receiving inpatient ECT for depression.We identified all psychiatric inpatients with a major depressive episode admitted to hospital ≥3 days in Ontario, Canada (2009 to 2017). The associa…
Publication
ID32071130Published Date2020-07-01JournalRespiratory care, 2020-07-01, Volume 65
We tested whether work of breathing in premature newborns estimated by phase angle (θ) by using respiratory inductance plethysmography is decreased during neurally-adjusted ventilatory assist (NAVA) noninvasive ventilation (NIV) versus NIV alone.NAVA NIV and NIV were applied in random order while using respiratory inductance plethysmography to measure the phase angle.Patient-ventilator asynchrony was decreased during NAVA NIV; however, the phase angle was not different between the modes. A la…
Publication
ID32345653Published Date2020-07-01JournalDiabetes care, 2020-07-01, Volume 43
To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA and continuous glucose monitoring over 12 months.Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%, = 1,298] vs. 4.7% [95% CI 3.4-5.9%, = 1…
Publication
ID32381574Published Date2020-07-01JournalHaematologica, 2020-07-01, Volume 105
Acquired hemophilia A (AHA), a rare bleeding disorder caused by neutralizing autoantibodies against coagulation factor VIII (FVIII), occurs in both men and women without a previous history of bleeding. Patients typically present with an isolated prolonged activated partial thromboplastin time due to FVIII deficiency. Neutralizing antibodies (inhibitors) are detected using the Nijmegen-modified Bethesda assay. Approximately 10% of patients do not present with bleeding and, therefore, a prolong…
Publication
ID32221582Published Date2020-07-01JournalEuropean heart journal, 2020-07-01, Volume 41
In the DAPA-HF trial, the SGLT2 inhibitor dapagliflozin reduced the risk of worsening heart failure (HF) and death in patients with HF and reduced ejection fraction. We examined whether this benefit was consistent in relation to background HF therapy.In this post hoc analysis, we examined the effect of study treatment in the following yes/no subgroups: diuretic, digoxin, mineralocorticoid receptor antagonist (MRA), sacubitril/valsartan, ivabradine, implanted cardioverter-defibrillating (ICD) …
Publication
ID32308190Published Date2020-07-01JournalPublic health nutrition, 2020-07-01, Volume 23
Test the efficacy and perceived effectiveness of nutrition labels on children's menus from a full-service chain restaurant in an online study.Using a between-groups experiment, parents were randomised to view children's menus displaying one of five children's nutrition labelling conditions: (i) No Nutrition Information (control); (ii) Calories Only; (iii) Calories + Contextual Statement (CS); (iv) Calories, Sodium + CS; or (v) Calories and Sodium in Traffic Lights + CS. Parents hypothetically…
Publication
ID32171774Published Date2020-07-01JournalThe American journal of medicine, 2020-07-01, Volume 133
Subclinical hypothyroidism has been associated with heart failure, but only small trials assessed whether treatment with levothyroxine has an impact on cardiac function.In a randomized, double-blind, placebo-controlled, trial nested within the TRUST trial, Swiss participants ages ≥65 years with subclinical hypothyroidism (thyroid-stimulating hormone [TSH] 4.60-19.99 mIU/L; free thyroxine level within reference range) were randomized to levothyroxine (starting dose of 50 µg daily) to achieve T…
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