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Publication
ID30267705Published Date2019-03-01JournalJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2019-03-01, Volume 77
The purpose of the present study was to evaluate the safety and efficacy of the compression-resistant collagen-based cross-linked matrix for augmentation of maxillary and mandibular soft tissue defects in an animal model.Six rhesus macaque monkeys were subjected to soft tissue grafting in 4 sites intraorally; the anterior maxilla was subjected to hard and soft tissue grafting with implant placement. Each site was randomly assigned 1 of 3 treatments: a compressive-resistant collagen matrix mem…
Publication
ID30831102Published Date2019-03-01JournalContraception, 2019-03-01
To evaluate safety outcomes from clinical studies of a 12-month contraceptive vaginal system (CVS) releasing an average of segesterone acetate (SA) 150 mcg and ethinyl estradiol (EE) 13 mcg daily.We integrated clinical safety data from nine studies in which women used the CVS for 21 consecutive days and removed it for 7 days of each 28-day cycle. Four studies used the final manufactured CVS, including a 1-year pharmacokinetic study, two 1-year phase 3 trials and a second-year treatment extens…
Publication
ID30600629Published Date2019-02-01JournalWorld psychiatry : official journal of the World Psychiatric Association (WPA), 2019-02-01, Volume 18
The validity of the classification of non-affective and affective psychoses as distinct entities has been disputed, but, despite calls for alternative approaches to defining psychosis syndromes, there is a dearth of empirical efforts to identify transdiagnostic phenotypes of psychosis. We aimed to investigate the validity and utility of general and specific symptom dimensions of psychosis cutting across schizophrenia, schizoaffective disorder and bipolar I disorder with psychosis. Multidimens…
Publication
ID30466909Published Date2019-02-01JournalMagnetic resonance imaging clinics of North America, 2019-02-01, Volume 27
Hematuria evaluation remains a common problem, particularly in patients who smoke and are at risk for urothelial tumors. Lifetime surveillance of the urothelium is often required once urothelial cancer is diagnosed. Computed tomography urography (CTU) has exquisite sensitivity and specificity for identification of renal and urothelial lesions. The examination is well accepted by patients and physicians. Possible harms include radiation exposure and contrast-induced nephropathy. MR imaging is …
Publication
ID30529783Published Date2019-02-01JournalSleep medicine, 2019-02-01, Volume 54
The International Restless Legs Study Group (IRLSSG) has developed the IRLS (International Restless Legs Syndrome Severity Scale) and validated it as a clinician/researcher administered scale to be used when both patient and examiner are present. The IRLSSG recognized the need for a self-completing scale that can be used economically in clinical practice and in large population-based studies. In this study the validity and the reliability of the IRLS as a self-administered scale (sIRLS) is as…
Publication
ID30890955Published Date2019-01-01JournalFrontiers in physiology, 2019-01-01, Volume 10
Peptide YY (PYY) is considered a gut peptide with roles in post-prandial appetite and glucose regulation. Circulating PYY protein levels increase during aerobic exercise. Furthermore, people who have greater increases in muscle progenitor cells (MPCs), the adult stem cell population responsible for skeletal muscle (SkM) repair, after resistance training have higher PYY transcript levels in SkM prior to training. Currently, examination of PYY expression patterns in SkM and/or MPCs is lacking. …
Publication
ID30581075Published Date2019-01-01JournalDNA repair, 2019-01-01, Volume 73
The integrating conjugative element ICE391 (formerly known as IncJ R391) harbors an error-prone DNA polymerase V ortholog, polV, encoded by the ICE391 rumAB operon. polV and its orthologs have previously been shown to be major contributors to spontaneous and DNA damage-induced mutagenesis in vivo. As a result, multiple levels of regulation are imposed on the polymerases so as to avoid aberrant mutagenesis. We report here, that the mutagenesis-promoting activity of polV is additionally regulat…
Publication
IDIEEE:8632264Published Date2018-12-12Conference2018 Winter Simulation Conference (WSC)
The growing global diabetes epidemic is a serious public health problem. We developed a system dynamic model to study the cost-effectiveness of different diabetes treatment options. According to existing literature, we estimated dynamic costs and changes of hemoglobin A1c levels of two first-line monotherapies and a hypothetical innovation therapy for glycemic control over a 15-year horizon. Incremental cost-effectiveness ratios were expressed as dollars per HbA1c decrement from perspectives …
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