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Patent
Publication NumberBR PI807251 A2Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2008-02-18Publication Date2019-09-24
Methods, oligonucleotides arrays etc. for treating inflammatory conditions and of predicting subject outcome based on polymorphisms in SERPINE1 and/or PROC, alone or in combination, wherein the method of treatment includes administering to the subject an anti-inflammatory agent or an anti-coagulant agent, wherein said subject is determined to have an improved response genotype or combination.
Patent
Publication NumberWO 2012068519 A2Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2011-11-18Publication Date2012-05-24
The present invention includes and provides biomarkers and methods for determining the effectiveness of treatment of immunological disorders with an anti-inflammatory agent or an anti-coagulant agent. Included are materials such as nucleic acid molecules capable to detecting genetic polymorphisms that are predictive of an improved response to an anti-inflammatory agent or an anti-coagulant agent.
Patent
Publication NumberWO 2009089620 A8Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2009-01-15Publication Date2012-04-26
Provided herein are methods, oligonucleotides and peptide nucleic acids, compositions and kits for predicting a subject's response to treatment with activated protein C or protein C-like compound or susceptibility to major organ dysfunction or susceptibility to an inflammatory condition. The method generally comprises determining a genotype of said subject at one or more of polymorphic sites in the subject's protein C gene selected from one or more of the following: rs20069915 and one or more…
Clinical Trial
Clinical Trial IDNCT01486524Start Date2011-10-01Completion Date2012-04-01Study TypeObservationalStatusUnknown status
The overall purpose of the study is to determine whether either of the Improved Response Polymorphisms (IRPs) individually predicts a differential DrotAA treatment effect in patients with severe sepsis and high risk of death. This will be an international, multicenter, "prospective-retrospective", nonrandomized, controlled, outcome-blinded, genotype-blinded, matched-patients study. No prospective enrollment or treatment of patients will occur under this protocol. Retrospectively collected cli…
Patent
Publication NumberUS 7820376Filing StatusIssued PatentAvailabilityUnknownFiling Date2003-05-28Publication Date2010-10-26
The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the patient to recover from the inflammatory condition and identifying patients based on the…
Patent
Publication NumberUS 20100209413Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2008-02-18Publication Date2010-08-19
Methods, oligonucleotides arrays etc. for treating inflammatory conditions and of predicting subject outcome based on polymorphisms in SERPINE1 and/or PROC, alone or in combination, wherein the method of treatment includes administering to the subject an anti-inflammatory agent or an anti-coagulant agent, wherein said subject is determined to have an improved response genotype or combination.
Patent
Publication NumberWO 2009033282 A8Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2008-09-10Publication Date2010-07-15
The present application provides methods, uses, commercial packages, and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and for identifying subjects having a greater benefit from treatment with an anti-inflammatory agent or an anti-coagulant agent. The method generally includes determining the genotype at position rs7222094 or a polymorphic site in linkage disequilibrium thereto for a subject for a polymorphisms in the these genes. The a…
Patent
Publication NumberCN 101688327 AFiling StatusPatent ApplicationAvailabilityUnknownFiling Date2008-02-18Publication Date2010-03-31
Methods, oligonucleotides arrays etc. for treating inflammatory conditions and of predicting subject outcome based on polymorphisms in SERPINE1 and/or PROC, alone or in combination, wherein the methodof treatment includes administering to the subject an anti-inflammatory agent or an anti-coagulant agent, wherein said subject is determined to have an improved response genotype or combination.
We found 22 documents that match your Search
Patents: 21
Clinical Trials: 1

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