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Publication
ID32113018Published Date2020-06-01JournalJournal of colloid and interface science, 2020-06-01, Volume 569
We investigated the formation behavior of supported lipid bilayers (SLBs) on polyelectrolyte multilayers (PEMs) prepared using the layer-by-layer method. The SLBs were formed using the liposome fusion method, which was driven by electrostatic interactions. We used three types of cationic polyelectrolytes to prepare PEMs: poly(diallyldimethylammonium chloride), which consists of a linear short polymer chain with quaternary ammonium cations, polyvinylamidin, which presents a linear, long polyme…
Publication
ID32299660Published Date2020-06-01JournalBioorganic & medicinal chemistry, 2020-06-01, Volume 28
Erypoegin K, an isoflavone isolated from the stem bark of Erythrina poeppigiana, has potent apoptosis-inducing effect on human leukemia HL-60 cells. Erypoegin K has a chiral carbon at the C-2'' position of its furan ring and naturally occurs as a racemic mixture of (S)- and (R)-isomers. In the present study, we semi-synthesized (RS)-erypoegin K from genistein and separated the optical isomers by HPLC using a chiral column to characterize its apoptosis-inducing activity. Apoptotic cell death w…
Publication
ID31797201Published Date2020-06-01JournalClinical journal of gastroenterology, 2020-06-01, Volume 13
We describe the case of a 70-year-old man with diabetic nephropathy undergoing hemodialysis. Four years following hemodialysis, he started taking lanthanum carbonate 1500 mg/day and lansoprazole 30 mg/day. Nine years following hemodialysis, he underwent screening esophagogastroduodenoscopy, which demonstrated the presence of the whitish cobblestone-like mucosa in the gastric corpus and multiple reddish depressed lesions with annular whitish mucosa in the antrum. With magnified narrow-band ima…
Publication
ID31745825Published Date2020-06-01JournalClinical journal of gastroenterology, 2020-06-01, Volume 13
Mixed connective tissue disease (MCTD) causes multiple organ dysfunctions, such as joint swelling, pulmonary fibrosis and hypertension, and serositis, but hepatopancreatic complications are rare. Here, we report a case of young man who exhibited acute severe liver dysfunction. He also had impaired cardiac function: both ventriculi were hypokinetic, but pulmonary hypertension and pericarditis were not observed. Since his liver and cardiac function markedly improved after commencing furosemide …
Publication
ID32036585Published Date2020-06-01JournalClinical rheumatology, 2020-06-01, Volume 39
Hypertrophic pachymeningitis (HP) related to anti-neutrophil cytoplasmic antibody (ANCA) is the most frequently seen immune-mediated HP. We investigated cerebrospinal fluid (CSF) biomarkers related to the pathogenesis of ANCA-related HP (ANCA-HP).The levels of B cell activation factor of the tumor necrosis factor family (BAFF), a proliferation-inducing ligand (APRIL), and transforming growth factor beta 1 (TGF-β1) in the CSF were compared between patients with ANCA-HP (n = 12), other types of…
Publication
ID32232936Published Date2020-06-02JournalAngewandte Chemie (International ed. in English), 2020-06-02, Volume 59
The three-dimensional structure of nanocomposite microgels was precisely determined by cryo-electron micrography. Several nanocomposite microgels that differ with respect to their nanocomposite structure, which were obtained from seeded emulsion polymerization in the presence of microgels, were used as model nanocomposite materials for cryo-electron micrography. The obtained three-dimensional segmentation images of these nanocomposite microgels provide important insights into the interactions…
Publication
ID32438508Published Date2020-05-21JournalLiver international : official journal of the International Association for the Study of the Liver, 2020-05-21
Although ursodeoxycholic acid (UDCA) is a first-line treatment for primary biliary cholangitis (PBC), 20-30% of patients with PBC exhibit an incomplete response to UDCA. Recently, the UDCA Response Score was proposed for predicting response to UDCA using pretreatment parameters in patients with PBC. We aimed to validate the UDCA Response Score in Japanese patients with PBC.Registry data of Japanese patients (n=873) were collected. Patients with data on all clinical parameters required for cal…
Publication
ID32440015Published Date2020-05-21JournalBone marrow transplantation, 2020-05-21
To investigate which reduced-intensity conditioning (RIC)/reduced-toxicity conditioning (RTC) is superior for umbilical cord blood transplantation (UCBT) for lymphoid malignancies, we retrospectively compared three widely used RIC/RTC regimens: fludarabine/melphalan/total body irradiation (FM-TBI, n = 524), fludarabine/cyclophosphamide/total body irradiation (FC-TBI, n = 96), and fludarabine/busulfan/total body irradiation or melphalan (FB-based, n = 159). Among patients with acute lymphoblas…
Publication
ID32447247Published Date2020-05-21JournalCytokine, 2020-05-21, Volume 133
We previously reported higher levels of C-C chemokine ligand (CCL) 1 in the bronchoalveolar lavage (BAL) fluid (BALF) of patients with sarcoidosis than in BALF of patients with immunoglobulin G4 (IgG4)-related disease (IgG4-RD), indicating that CCL1 might act as a marker of disease activity in sarcoidosis. Notably, less invasive sampling sources are desirable, as BAL cannot always be performed due to its inherent risk. In this study, we sought to decipher the correlation between serum levels …
Publication
ID32431246Published Date2020-05-20JournalJournal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2020-05-20
To determine whether limb-based patency (LBP) after infrainguinal revascularization for chronic limb-threatening ischemia (CLTI) is similar between bypass surgery and endovascular therapy (EVT).The database for the urgical Reconstruction vs eripheral tervention in Ptients With Critical Limb Isemia (SPINACH) study was interrogated to identify 130 patients (mean age 73±8 years; 94 men) who underwent bypass surgery and 271 patients (mean age 74±10 years; 178 men) who underwent EVT alone. Skin pe…
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