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Company (114)University (3)Research Institution (1)
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Research Grant
Project Number1R44AI155307-01Funding AgencyNational Institutes of HealthEffective Date2020-07-13Expiration Date2021-06-30Funding Amount$1,000,000
Scarab Genomics? C-Flow? technology is a highly efficient continuous culture system that can produce kilograms of protein in a few weeks at a mere 10-liter scale. This project will determine whether C-Flow can be further developed as an efficient system for production of single-chain antibody therapeutics. Antibody fragments, especially single-chain variants, are increasingly important for diagnostic and therapeutic use such as toxin and virus neutralization, being relatively easy to manufact…
Patent
Publication NumberUS 20200216798Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2020-03-19Publication Date2020-07-09
Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.
Patent
Publication NumberUS 20200207804Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-04-03Publication Date2020-07-02
The present invention relates to the use of redox agents for purification of the CRM 197 variant of diphtheria toxin. The invention further relates to multi-step purification of CRM 197 from bacterial fermentates.
Research Grant
Project Number5R44AI143170-03Funding AgencyNational Institutes of HealthEffective Date2020-07-01Expiration Date2021-06-30Funding Amount$737,950
Thirty percent of recombinant therapeutic proteins are made in E. coli and include important vaccine components such as carrier proteins. Further, burgeoning new immunotherapies that use proteins such as single chain antibodies and virus-like particles are enjoying increasing success. To meet the production needs of these expanding areas, Scarab Genomics proposes to extend the versatility of its Clean Genome E.coli production system to include a method by which recombinant therapeutic protein…
Patent
Publication NumberUS 10604736Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-04-01Publication Date2020-03-31
A two-vessel continuous flow system in conjunction with low mutation reduced genome bacterial strains provides a platform for long term extended fermentations. Such systems require modification of standard fermentation devices such as probes, pumps and monitoring systems as well as improved procedures for feed delivery, culture monitoring and product harvesting methods. An optimized two-vessel system for producing large quantities of fermentation products from small volume, long duration cont…
Research Grant
Project Number5R44AI094823-05Funding AgencyNational Institutes of HealthEffective Date2020-03-01Expiration Date2021-02-28Funding Amount$1,000,000
Scarab Genomics has established a unique, tiny footprint, extended bacterial fermentation process enabled by its reduced genome E. coli, for production of protein therapeutics, especially vaccine conjugates. The process will massively reduce the cost and upgrade the quality of these critical vaccine components. This Phase IIB resubmission focuses on commercial development of Scarab?s first vaccine product, the diphtheria mutant toxin CRM197, an important component of highly successful conjuga…
Patent
Publication NumberJP 1650088 SFiling StatusIssued PatentAvailabilityUnknownFiling Date2019-05-27Publication Date2020-01-20
Patent
Publication NumberUS 10479820Filing StatusIssued PatentAvailabilityUnknownFiling Date2015-03-02Publication Date2019-11-19
Rediced genome or native K12 strain E. coli bacteria comprising expression vectors encoding a recombinant CRM197 protein and their use in the production of CRM 197 is provided. The CRM 197 protein may be fused to a signal sequence that directs the expressed CRM197 protein to the periplasm of the E. coli host.
Patent
Publication NumberKR 102043891 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-10-19Publication Date2019-11-12
Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
Patent
Publication NumberEP 3068887 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-11-13Publication Date2019-10-30
We found 114 documents that match your Search
Research Grants: 34
Patents: 80

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