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Publication
ID29294672Published Date2020-03-01JournalJournal of interpersonal violence, 2020-03-01, Volume 35
The objective of this article is to examine the individual and relational characteristics of adolescent girls with a history of physical DV, as well as to utilize partner-specific, temporal data to explore links between these factors and recent or ongoing DV experiences. Participants were 109 high school girls (ages 14-17) identified as having a history of DV through a school-based screening procedure. Details regarding the timing of DV and links with specific dating partners were gathered us…
Publication
ID31866506Published Date2020-03-01JournalBiochimica et biophysica acta. Proteins and proteomics, 2020-03-01, Volume 1868
Replication Protein A (RPA) is a single-stranded DNA binding protein that interacts with DNA repair proteins including Uracil DNA Glycosylase (UNG2). Here, I report DNA binding and activity assays using purified recombinant RPA and UNG2. Using synthetic DNA substrates, RPA was found to promote UNG2's interaction with ssDNA-dsDNA junctions regardless of the DNA strand polarity surrounding the junction. RPA stimulated UNG2's removal of uracil bases paired with adenine or guanine in DNA as much …
Publication
ID31953165Published Date2020-03-01JournalLife sciences, 2020-03-01, Volume 244
Vismodegib is an effective antagonist of smoothened receptors for treatment of locally advanced or metastatic basal cell carcinoma. However, it often suffers from drug resistance due to mutations. Two common mutants, D473G and W535L, were found to cause serious drug resistance. Although the reduction of drug binding affinity (~40-fold) was thought to be the major reasons, the detailed structural, energetic and dynamic mechanisms at the molecular level are still unknown.Molecular dynamics simu…
Publication
ID31904559Published Date2020-03-01JournalActa biomaterialia, 2020-03-01, Volume 104
The disruption of the blood-spinal cord barrier (BSCB) following spinal cord injury contributes to inflammation and glial scarring that inhibits axon growth and diminishes the effectiveness of conduits transplanted to the injury site to promote this growth. The purpose of this study is to evaluate whether scaffolds containing microvessels that exhibit BSCB integrity reduce inflammation and scar formation at the injury site and lead to increased axon growth. For these studies, a self-assemblin…
Publication
ID31652235Published Date2020-03-01JournalMedicine and science in sports and exercise, 2020-03-01, Volume 52
The periodization of resistance exercise is often touted as the most effective strategy for optimizing muscle size and strength adaptations. This narrative persists despite a lack of experimental evidence to demonstrate its superiority. In addition, the general adaptation syndrome, which provides the theoretical framework underlying periodization, does not appear to provide a strong physiological rationale that periodization is necessary. Hans Selye conducted a series of rodent studies which …
Publication
ID32065031Published Date2020-02-17JournalJournal of interpersonal violence, 2020-02-17
College students are at increased risk for dating violence (DV) perpetration and victimization. One group of college students who may be at elevated risk is college student-athletes. While levels of athletic involvement range from National Collegiate Athletic Association (NCAA) Division I to Division III, there is currently a lack of information about the dating and relationship behaviors of male and female Division III student-athletes. This study identified the frequency of both minor and s…
Research Grant
Award Number2005570Funding AgencyNational Science FoundationEffective Date2020-02-15Expiration Date2020-07-31Funding Amount$50,000
The broader impact/commercial potential of this I-Corps project will be the development of a device for treating long bone fractures using robotic technology. Approximately 350,000 proximal femur fractures and 65,000 femur shaft fractures occur in the United States annually. Current surgical procedures are manual, and patients experience a myriad of complications to align femur fractures, including difficulty in achieving accurate reduction, subsequent malalignment of bone fragments, high x-r…
Publication
ID32059031Published Date2020-02-14JournalPLoS pathogens, 2020-02-14, Volume 16
Many bacteria use quorum sensing (QS) to regulate virulence factor production in response to changes in population density. QS is mediated through the production, secretion, and detection of signaling molecules called autoinducers (AIs) to modulate population-wide behavioral changes. Four histidine kinases, LuxPQ, CqsS, CqsR and VpsS, have been identified in Vibrio cholerae as QS receptors to activate virulence gene expression at low cell density. Detection of AIs by these receptors leads to …
Publication
ID32058456Published Date2020-02-13JournalNursing research, 2020-02-13
Death by suicide is the second leading cause of death among adolescents globally. Healthy People 2020 set a goal to reduce by 10% the rate of suicide attempts that required treatment and designated the Youth Risk Behavior Survey (YBRS) to measure this objective.This study used cross-sectional YBRS data (2009-2017) to investigate whether (a) gender moderates the linear time trend for the rate of depressive symptoms, suicidal ideation, and suicide attempts among high school students within the …
Patent
Publication NumberUS 20200048301Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-08-13Publication Date2020-02-13
The present invention relates to the unexpected discovery of novel monomer compounds capable of crosslinking interpenetrating polymer networks (IPNs). In certain embodiments, the monomer compounds of the invention each comprise at least one methacrylate functionality capable of forming polymeric bonds with other methacrylate and vinyl functionalities, and at least one epoxide functionality capable of forming polymeric bonds with epoxide functionalities, amine functionalities, and/or reactive …
We found 2,214 documents that match your Search
Research Grants: 177
Publications: 1,944
Patents: 74
Clinical Trials: 19

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