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Publication
ID32402752Published Date2020-06-09JournalVaccine, 2020-06-09, Volume 38
Different schedules for pediatric use of the 13-valent pneumococcal conjugate vaccine (PCV-13) are recommended in different countries and the U.S. Advisory Committee on Immunization Practices (ACIP) has considered potential of changing from 3 primary doses plus a booster (3p + 1) to two primary doses plus a booster (2p + 1) for protection against Streptococcus pneumoniae. In this paper, we report results of IgG antibody measured by ELISA and opsonophagocytic assay (OPA) after 2p, 3p, at child…
Publication
ID32205139Published Date2020-06-01JournalThe Journal of infection, 2020-06-01, Volume 80
Acute Otitis Media (AOM) is a multifactorial disease occurring mostly in young children who are immunologically naïve to AOM pathogens. This review focuses on work from Rochester NY, USA over the past 12 years among young children who had AOM infections microbiologically-confirmed by tympanocentesis, so called "stringently-defined". Among stringently-defined otitis prone children deficiencies in fundamental immune defense mechanisms have been identified that contribute to the propensity of yo…
Publication
ID32401658Published Date2020-05-13JournalHuman vaccines & immunotherapeutics, 2020-05-13
Since their widespread use, pneumococcal conjugate vaccines (PCVs) have proven effective at reducing both invasive and noninvasive pneumococcal diseases and nasopharyngeal carriage of (). To establish this level of protection, a three-dose schedule with a single booster (3 + 1) was the immunization regime in the USA. Alternatively, WHO-approved schedules of 3 + 0 and 2 + 1 are now becoming adopted in many countries to reduce the cost of vaccination. Sustained protection from pneumococcal dise…
Publication
ID32007292Published Date2020-03-01JournalInternational journal of pediatric otorhinolaryngology, 2020-03-01, Volume 130 Suppl 1
To review the most recent advances in human and bacterial genomics as applied to pathogenesis and clinical management of otitis media.PubMed articles published since the last meeting in June 2015 up to June 2019.A panel of experts in human and bacterial genomics of otitis media was formed. Each panel member reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The panel met at the 20th Intern…
Publication
ID32067037Published Date2020-02-18JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020-02-18
Antibiotic-resistant S. pneumoniae strains may cause infections that fail to respond to antimicrobial-therapy. Results reported from hospitalized patients with invasive, bacteremic infections may not be the same as those observed in a primary-care setting where young children receive care for non-invasive infections. Young children experience the highest burden of pneumococcal disease.To determine the antibiotic susceptibility of S. pneumoniae strains isolated from children in a primary-care …
Publication
ID31222732Published Date2019-08-01JournalJournal of neurochemistry, 2019-08-01, Volume 150
Neurotoxicology is hampered by the inability to predict regional and cellular targets of toxicant-induced damage. Evaluating astrogliosis overcomes this problem because reactive astrocytes highlight the location of toxicant-induced damage. While enhanced expression of glial fibrillary acidic protein is a hallmark of astrogliosis, few other biomarkers have been identified. However, bacterial artificial chromosome - translating ribosome affinity purification (bacTRAP) technology allows for char…
Publication
ID31262582Published Date2019-07-26JournalVaccine, 2019-07-26, Volume 37
Determining a recommended dosage schedule is a crucial component of vaccine administration, and is often subject to reassessment. Ideally, recommendations will be supported by multiple arm clinical trials. However, the considerable cost in both resources and time means that a method of predicting post-vaccine humoral antibody levels associated with a hypothetical schedule using data collected from a currently implemented schedule would be of significant benefit to vaccination practice. In thi…
Publication
ID28755833Published Date2019-07-26JournalVaccine, 2019-07-26, Volume 37
Moraxella catarrhalis (Mcat) is a frequent pathogen of acute otitis media (AOM) in young children. Here we prospectively assessed naturally-induced serum antibodies to four Mcat vaccine candidate proteins in stringently defined otitis prone (sOP) and non-otitis prone (NOP) children age 6-36months old following nasopharyngeal (NP) colonization, at onset of AOM and convalescence from AOM.Serum IgG and IgM antibody against recombinant Mcat proteins, oligopeptide permease A (OppA), outer membrane…
Publication
ID30188973Published Date2019-04-24JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019-04-24, Volume 68
Viral upper respiratory infections (URIs) are common and often precipitate acute otitis media (AOM), caused by bacterial otopathogens, in young children. Acute inflammatory responses initiated in the early phase of viral URI contribute to preventing the development of AOM. Stringently-defined otitis-prone (sOP) children are susceptible to recurrent AOM.We assessed proinflammatory cytokine and chemokine levels in the nasopharynxes during viral URIs, and examined the different nasopharyngeal re…
Publication
ID30566236Published Date2019-03-01JournalEuropean journal of immunology, 2019-03-01, Volume 49
Non-typeable Haemophilus influenzae (NTHi) is a pathogen that commonly colonizes the nasopharynx of preschool children, causing opportunistic infections including acute otitis media (AOM). Patients suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized with NTHi and occasionally suffer from exacerbations by the bacterium leading to increased morbidity. Elongation-factor thermo unstable (EF-Tu), a protein critical for bacterial protein synthesis, has been found …
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