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Research Grant
Award Number2015964Funding AgencyNational Science FoundationEffective Date2020-07-01Expiration Date2023-06-30Funding Amount$390,529
This award will advance our fundamental understanding of how cells sense and react to diverse mechanical inputs from their environments. Cells utilize local environmental cues from the extracellular matrix (ECM), adhesive molecules, and local stiffness to make decisions about growth and movement. The process of converting mechanical stimulus to electrical energy at the ECM is commonly thought to act via adhesion proteins such as integrins. Emerging research on Piezo ion channels reveals that …
Publication
ID31512036Published Date2020-07-01JournalSurgical endoscopy, 2020-07-01, Volume 34
While better technical performance correlates with improved outcomes, there is a lack of procedure-specific tools to perform video-based assessment (VBA). SAGES is developing a series of VBA tools with enough validity evidence to allow reliable measurement of surgeon competence. A task force was established to develop a VBA tool for laparoscopic fundoplication using an evidence-based process that can be replicated for additional procedures. The first step in this process was to seek content v…
Publication
ID32344185Published Date2020-07-01JournalBioorganic chemistry, 2020-07-01, Volume 100
The Neuropilin (Nrp) family of cell surface receptors have key physiological and pathological functions. Nrp2 is of particular interest due to its involvement in tumor metastasis. Currently, peptide and small molecule inhibitors that target Nrp utilize arginine-based molecules which have limitations due to high inherent flexibility and issues related to stability. Further, there are no known small molecule inhibitors specific for Nrp2. Recent molecular insights identify a key ligand binding r…
Publication
ID31543062Published Date2020-07-01JournalJournal of palliative care, 2020-07-01, Volume 35
The purpose of this review was to evaluate end-of-life care (EOLC) in the intensive care unit (ICU) from the perspective of family members. Sandelowski's segregated approach from Joanna Briggs Institute (JBI) Mixed-Methods Systematic Reviews guided this review. A search was conducted in PubMed, CINAHL, PsycINFO, EMBASE, and ProQuest databases and identified 50 papers (33 quantitative, 15 qualitative, and 2 mixed-methodology studies). Five synthesized themes (distressing emotions, shared decis…
Publication
ID32167182Published Date2020-07-01JournalJournal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020-07-01, Volume 38
A preclinical rat knee replacement model was recently developed to explore the biological and mechanobiological changes of trabecular resorption for cement-bone interdigitated regions. The goal here was to evaluate the relevance of this model compared with human knee replacement with regards to functional micromechanics. Eight nonsurvival, cemented knee replacement surgeries were performed, the interdigitated gap morphology was quantified, and interface micromotion between cement and bone was…
Publication
ID32190944Published Date2020-07-01JournalGlobal change biology, 2020-07-01, Volume 26
Understanding the scales at which environmental variability affects populations is critical for projecting population dynamics and species distributions in rapidly changing environments. Here we used a multilevel Bayesian analysis of range-wide survey data for Adélie penguins to characterize multidecadal and annual effects of sea ice on population growth. We found that mean sea ice concentration at breeding colonies (i.e., "prevailing" environmental conditions) had robust nonlinear effects on…
Publication
ID31372890Published Date2020-07-01JournalSurgical endoscopy, 2020-07-01, Volume 34
Percutaneous cholecystostomy tube (PCT) placement is often the initial management approach to severe acute cholecystitis in the unstable patient. However, the timing of cholecystectomy after PCT has not been carefully examined. The purpose of this study was to compare outcomes of early versus late cholecystectomy following PCT placement.The New York SPARCS administrative database was searched for all patients undergoing PCT placement between 2000 and 2012. Patients were followed for subsequen…
Research Grant
Award Number1947981Funding AgencyNational Science FoundationEffective Date2020-07-01Expiration Date2023-06-30Funding Amount$665,013
The rate at which the Arctic has warmed during the past 50 years is likely faster than anytime during the past 7 millennia, and temperatures will likely continue to rise during the coming centuries. This research uses geological evidence and model simulations to study the Arctic system?s response to past warming events that had similar rate and duration to that of modern warming. This project provides detailed insights into the temperature and ocean-atmosphere circulation changes associated w…
Publication
ID32456964Published Date2020-07-01JournalTrends in parasitology, 2020-07-01, Volume 36
Lyme disease is the most common vector-borne disease in the northern hemisphere and is caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Lyme borreliae infect diverse vertebrate reservoirs without triggering apparent manifestations in these animals; however, Lyme borreliae strains differ in their reservoir hosts. The mechanisms that drive those differences are unknown. To survive in vertebrate hosts, Lyme borreliae require the ability to escape from host defense mechanisms…
Publication
ID31927648Published Date2020-07-01JournalAdministration and policy in mental health, 2020-07-01, Volume 47
Despite the high prevalence of substance use disorders among juvenile offenders, most do not receive services. System-level process improvement plans to address unmet service needs can be optimized by combining data-driven decisions and facilitated meetings with behavioral health stakeholders. This paper operationalizes and analyzes the level of specified complexity among process improvement plans evident within 36 juvenile probation and drug courts across 7 states. To inform more effective i…
We found 146,793 documents that match your Search
Research Grants: 31,880
Publications: 109,901
Patents: 3,164
Clinical Trials: 707
Opportunities: 465
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