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Foundation (137.2K)University (113.4K)Research Institution (10.1K)Hospital (7.8K)Company (1.9K)Other (326)Investor (128)
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Publication
ID31444887Published Date2019-12-15JournalHuman brain mapping, 2019-12-15, Volume 40
Cognitive reserve is one's mental resilience or resistance to the effects of structural brain damage. Reserve effects are well established in people with multiple sclerosis (PwMS) and Alzheimer's disease, but the neural basis of this phenomenon is unclear. We aimed to investigate whether preservation of functional connectivity explains cognitive reserve. Seventy-four PwMS and 29 HCs underwent neuropsychological assessment and 3 T MRI. Structural damage measures included gray matter (GM) atrop…
Research Grant
Award Number1918455Funding AgencyNational Science FoundationEffective Date2019-12-15Expiration Date2022-11-30Funding Amount$333,453
NONTECHNICAL SUMMARYThis award supports computational and theoretical research, and education on flexoelectricity.If a strain gradient is applied to a piece of an electrically insulating material, for example by bending it, a voltage will be created across the material. This effect, known as flexoelectricity, has attracted attention because of the possibility for technological applications such as actuators, deflection sensors, and energy harvesters. Also, flexoelectricity is i…
Publication
ID31422797Published Date2019-12-15JournalBiological psychiatry, 2019-12-15, Volume 86
An early-life anxious temperament (AT) is a risk factor for the development of anxiety, depression, and comorbid substance abuse. We validated a nonhuman primate model of early-life AT and identified the dorsal amygdala as a core component of AT's neural circuit. Here, we combine RNA sequencing, viral-vector gene manipulation, functional brain imaging, and behavioral phenotyping to uncover AT's molecular substrates.In response to potential threat, AT and brain metabolism were assessed in 46 y…
Publication
ID31679644Published Date2019-12-15JournalThe American journal of cardiology, 2019-12-15, Volume 124
Previous studies regarding benefit of extracorporeal membrane oxygenation (ECMO) in adults with cardiac arrest have yielded conflicting results. We aimed to determine whether ECMO in adults hospitalized with cardiac arrest is associated with improved survival compared with conventional cardiopulmonary resuscitation in a nationally representative sample. The U.S. Healthcare Cost and Utilization Project's Nationwide Inpatient Sample (2006 to 2014) was utilized to identify a cohort of adults hos…
Publication
ID31714426Published Date2019-12-15JournalJournal of acquired immune deficiency syndromes (1999), 2019-12-15, Volume 82
Despite potential for dependence and adverse neurological effects, long-term benzodiazepine (BZD) use is common among people living with HIV (PLWH). As PLWH are at risk for central nervous system dysfunction, we retrospectively examined the association between BZD use and HIV-associated neurocognitive impairment (NCI).Three hundred six PLWH underwent comprehensive neurobehavioral evaluations. Current BZD use (BZD+) was determined through self-report. Using propensity scores, 153 BZD- individu…
Publication
ID31675629Published Date2019-12-15JournalJournal of neuroimmunology, 2019-12-15, Volume 337
Prior work has established that that an acute ethanol challenge mimicking high intensity alcohol consumption increased IL-6 and suppressed IL-1β and TNFα mRNA in intoxication, with the opposite pattern seen in withdrawal. These experiments utilized Sprague-Dawley rats to further extend these results across time course (from 45 min to 6 h after ethanol), sex, and central versus peripheral expression. Furthermore, these data show that cannulation surgery may selectively modify the central neuro…
Publication
ID31382252Published Date2019-12-11JournalJournal of physics. Condensed matter : an Institute of Physics journal, 2019-12-11, Volume 31
Mainstream among topological insulators, GaSb/InAs quantum wells present a broken gap alignment for the energy bands which supports the quantum spin Hall insulator phase and forms an important building block in the search of exotic states of matter. Such structures allow the band-gap inversion with electrons and holes confined in adjacent layers, providing a fertile ground to tune the corresponding topological properties. Using a full 3D eight-band [Formula: see text] method we investigate th…
Publication
ID31326514Published Date2019-12-20JournalProgress in neuro-psychopharmacology & biological psychiatry, 2019-12-20, Volume 95
One of the main challenges in suicide prevention is the limited understanding of the biological mechanisms underlying suicide. Recent findings suggest impairments in pain processing in acutely suicidal patients. However, little is known about the biological factors that may drive these discrete physiological abnormalities. In this study, we examined plasma peptides involved in analgesic and inflammatory responses and physical pain threshold in acutely suicidal patients.Thirty-seven depressed …
Publication
ID31690919Published Date2019-12-07JournalPhysical chemistry chemical physics : PCCP, 2019-12-07, Volume 21
Liposomes carrying membrane-embedded porphyrin-phospholipid (PoP) are capable of chemo- and photo-therapeutic modes of action, which make them a potential candidate material for next-generation cancer treatments. This study examines singlet oxygen (O) production and release by PoP liposomes carrying either no chemotherapeutic cargo (EMPTY), or those carrying either doxorubicin (DOX) or irinotecan (IRT) chemotherapy drugs. Herein, we developed a strategy to quantify the fraction of O lifetime …
Publication
ID31525321Published Date2019-12-21JournalJournal of theoretical biology, 2019-12-21, Volume 483
Lysogens are bacterial cells that have survived after genomically incorporating the DNA of temperate bacteriophages infecting them. If an infection results in lysogeny, the lysogen continues to grow and divide normally, seemingly unaffected by the integrated viral genome known as a prophage. However, the prophage can still have an impact on the host's phenotype and overall fitness in certain environments. Additionally, the prophage within the lysogen can activate the lytic pathway via spontan…
We found 137,262 documents that match your Search
Research Grants: 31,259
Publications: 100,263
Patents: 3,076
Clinical Trials: 1,926
Opportunities: 34
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