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Publication
ID32346551Published Date2020-06-12JournalMolecular therapy. Methods & clinical development, 2020-06-12, Volume 17
We have examined the role of a novel targeted cytokine, interleukin-27 (IL-27), modified at the C terminus with a dual targeting and therapeutic heptapeptide, in treating prostate cancer. IL-27 has shown promise in halting tumor growth and mediating tumor regression in several cancer models, including prostate cancer. We describe our findings on the effects of targeted IL-27 gene delivery on prostate cancer cells and and how the targeting enhances bioactivity of the IL-27 cytokine. We applied…
Research Grant
Award Number1952366Funding AgencyNational Science FoundationEffective Date2020-06-01Expiration Date2023-05-31Funding Amount$24,800
Algebraic Geometry studies algebraic varieties which are geometric objects defined by polynomial equations. One of the most natural problems in this area is to understand the singularities that naturally occur when considering algebraic varieties and how these singularities influence the global geometry of algebraic varieties. In recent years there have been a number of breakthroughs, especially in the case where we consider solutions over the complex numbers. At the same time new techniques …
Publication
ID32142881Published Date2020-06-01JournalNeuroImage, 2020-06-01, Volume 213
Psychological assessments typically rely on self-report and behavioral measures. Augmenting these with neurophysiological measures of the construct in question may increase the accuracy and predictive power of these assessments. Moreover, thinking about neurophysiological measures from an assessment perspective may facilitate under-utilized research approaches (e.g., brain-based recruitment of participants). However, the lack of normative data for most neurophysiological measures has prevente…
Publication
ID31550991Published Date2020-06-01JournalJournal of medical screening, 2020-06-01, Volume 27
Understanding lung cancer screening behaviour is crucial to identifying potentially modifiable factors for future intervention. Qualititative work has explored attitudes and beliefs about lung cancer screening from the perspective of the participant, but the theoretically grounded factors that influence screening-eligible individuals to screen are unknown. We tested an explanatory framework for lung cancer screening participation from the individual's perspective.Data were collected as part o…
Publication
ID30945950Published Date2020-06-01JournalHealth communication, 2020-06-01, Volume 35
New guidelines for cervical cancer screening (CCS) incorporate both HPV and Pap tests, and there is a need to understand communication of these cotesting results to patients, especially in at-risk populations disproportionally affected by cervical cancer. This study used computer-assisted telephone interviews in 2017 at 51 federally qualified health centers (FQHCs) in Indiana to evaluate the characteristics of clinical communication CCS results to women. Results revealed that clinical communi…
Publication
ID32142715Published Date2020-06-01JournalJournal of pharmaceutical sciences, 2020-06-01, Volume 109
Excipients used in drug formulations at clinically safe levels have been considered to be pharmacologically inert; however, numerous studies have suggested that many solubilizing agents may modulate drug transporter activities and intestinal absorption. Here, the reported interactions between various solubilizing excipients and drug transporters are evaluated to consider various potential underlying mechanisms. This forms the basis for debate in the field in regard to whether or not the effec…
Publication
ID32236898Published Date2020-06-01JournalNeurotoxicity research, 2020-06-01, Volume 38
Methylmercury (MeHg) is a global pollutant and potent neurotoxin. In humans, MeHg damages the central nervous system (CNS), causing irreversible neuronal shrinkage, and neuronal loss. Most chelators for clinical mercury detoxification are thiol-containing agents. N,N 'bis-(2-mercaptoethyl) isophthalamide (NBMI) is a lipophilic thiol agent synthesized from natural chemicals. NBMI has high affinity for mercury, cadmium and lead, and can decrease their concentrations in polluted water. However, …
Publication
ID32062203Published Date2020-06-01JournalChemosphere, 2020-06-01, Volume 249
Honeydew production is a characteristic of soft scales and other hemipteran insects. Honeydew has the capacity to alter the ecology of predators and parasitoids because it is used as a food resource and can contain insecticidal proteins from hemipteran host plants. We examined honeydew excreted by the striped pine scale (Hemiptera: Coccidae), Toumeyella pini (King), after feeding on pine trees treated with systemic insecticides to determine whether they could eliminate insecticidal compounds …
Publication
ID30368558Published Date2020-06-01JournalPsychological research, 2020-06-01, Volume 84
Categorization decisions are made thousands of times every day, and a typical adult knows tens of thousands of categories. It is thus relatively rare that adults learn new categories without somehow reorganizing pre-existing knowledge. Yet, most perceptual categorization research has investigated the ability to learn new categories without considering they relation to existing knowledge. In this article, we test the ability of young adults to merge already known categories into new categories…
Publication
IDDOI:10.1115/1.4046557Published Date2020-06-01JournalJournal of Electronic Packaging, 2020-06-01, Volume 142
Abstract With the increase in the new development of paper electronics, there is a great demand for paper-compatible and reliable electrical joining techniques. In this work, we particularly addressed the interconnecting of multilayers of paper-based magneto-electronics. We deployed three room-temperature electrical joining techniques: (i) through-paper via, (ii) mechanical caulking, and (iii) collapsible daisy chain to fabricate an anisotropic magnetoresistive five-layer thin film sensor sta…
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Research Grants: 11,739
Publications: 58,579
Patents: 6,169
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