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Patent
Publication NumberUS 20200078313Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-12-29Publication Date2020-03-12
Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.
Patent
Publication NumberAU 2014296278 B2Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-07-30Publication Date2019-12-05
Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of deliveri…
Patent
Publication NumberBR PI912159 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2009-05-13Publication Date2019-11-05
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane including an extracellular membrane, an intracellular membrane, a vesicle, a…
Patent
Publication NumberUS 10420790Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-04-27Publication Date2019-09-24
Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
Patent
Publication NumberUS 10066043Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-02-08Publication Date2018-09-04
Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective ω-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.
Patent
Publication NumberUS 20180243433Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-11-30Publication Date2018-08-30
Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of deliveri…
Patent
Publication NumberUS 20180221402Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2016-01-21Publication Date2018-08-09
Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.
Patent
Publication NumberWO 2018126084 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-12-29Publication Date2018-07-05
Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.
Patent
Publication NumberUS 20180171056Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-11-30Publication Date2018-06-21
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, …
SEC Filing
Accession Number0001144204-18-005498Form Type8-KAcceptance Date2018-02-02
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported):February 1, 2018 PhaseRx, Inc. (Exact name of registrant as specified inits charter) Delaware 001-37772 20-4690620 (State or other jurisdiction of incorporation) (Commission File Number) (IRS Employer Identification No.) 410 W. Harrison Street, Suite 300 Seattle, Washing…
We found 178 documents that match your Search
Patents: 131
SEC Filings: 47

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