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ID32098784Published Date2020-04-01JournalLife science alliance, 2020-04-01, Volume 3
The scavenger receptor cysteine-rich (SRCR) family of proteins comprises more than 20 membrane-associated and secreted molecules. Characterised by the presence of one or more copies of the ∼110 amino-acid SRCR domain, this class of proteins have widespread functions as antimicrobial molecules, scavenger receptors, and signalling receptors. Despite the high level of structural conservation of SRCR domains, no unifying mechanism for ligand interaction has been described. The SRCR protein SALSA,…
Publication
ID31955409Published Date2020-04-01JournalClinical pharmacology and therapeutics, 2020-04-01, Volume 107
Alzheimer's disease (AD) is the leading cause of dementia worldwide. With 35 million people over 60 years of age with dementia, there is an urgent need to develop new treatments for AD. To streamline this process, it is imperative to apply insights and learnings from past failures to future drug development programs. In the present work, we focus on how modeling and simulation tools can leverage open data to address drug development challenges in AD.
Publication
ID31899810Published Date2020-04-01JournalClinical pharmacology and therapeutics, 2020-04-01, Volume 107
Our goal was to assess the enrichment utility of hippocampal volume (HV) as an enrichment biomarker in amnestic mild cognitive impairment (aMCI) clinical trials, and, hence, develop an HV neuroimaging-informed clinical trial enrichment tool. Modeling of integrated longitudinal patient-level data came from open-access natural history studies in patients diagnosed with aMCI-the Alzheimer's Disease Neuroimaging Initiative (ADNI)-1 and ADNI-2-and indicated that a decrease of 1 cm with respect to …
Publication
ID31895881Published Date2020-04-01JournalThe Pediatric infectious disease journal, 2020-04-01, Volume 39
Broadly protective pneumococcal vaccines that are affordable for low-resource countries are needed. Streptococcus pneumoniae whole cell vaccine (wSp) is an investigational vaccine that contains killed cells from a nonencapsulated strain of S. pneumoniae (SPn) with aluminum hydroxide adjuvant. Studies in mice demonstrated protection against nasopharyngeal carriage (T-cell-mediated) and invasive pneumococcal disease (antibody-mediated). The aim of this randomized, double-blind, placebo-controll…
Publication
ID32087841Published Date2020-04-01JournalJournal of substance abuse treatment, 2020-04-01, Volume 111
To date, few programs that integrate traditional practices with evidence-based practices have been developed, implemented, and evaluated with urban American Indians/Alaska Natives (AI/ANs) using a strong research design. The current study recruited urban AI/AN teens across northern, central, and southern California during 2014-2017 to participate in a randomized controlled trial testing two cultural interventions that addressed alcohol and other drug (AOD) use. Adolescents were 14-18 years ol…
Publication
ID30929156Published Date2020-04-01JournalInvestigational new drugs, 2020-04-01, Volume 38
Purpose SM-88 (D,L-alpha-metyrosine; racemetyrosine) is a novel anti-cancer agent, used with melanin, phenytoin, and sirolimus (SMK Therapy). This pilot first-in-human study characterized the safety, tolerability, and efficacy of SMK Therapy in subjects with advanced metastatic cancer. Methods All subjects (n = 30) received SMK Therapy for an initial 6 week Cycle (5 days on, 2 off per week) and continued if well tolerated. Safety signals, clinical response, overall survival, progression free …
Publication
IDDOI:10.1155/2020/8978041Published Date2020-03-23JournalThe Scientific World Journal, 2020-03-23, Volume 2020
Nepal is facing a large-scale labour migration—both internal and international—driven by economic and employment opportunities. There is sparse literature available at the national level which examines the link between migration and contraceptive use. This study aimed at identifying contraceptive use and the unmet need for family planning (FP) and exploring its correlates among the married women of reproductive age (MWRA) by their husbands’ residence status, using data from Nepal Demographic …
Publication
ID32183833Published Date2020-03-17JournalMalaria journal, 2020-03-17, Volume 19
New strategies are needed to reduce the incidence of malaria, and promising approaches include the development of vaccines and monoclonal antibodies (mAbs) that target the circumsporozoite protein (CSP). To select the best candidates and speed development, it is essential to standardize preclinical assays to measure the potency of such interventions in animal models.Two assay configurations were studied using transgenic Plasmodium berghei expressing Plasmodium falciparum full-length circumspo…
Publication
ID32085954Published Date2020-03-17JournalVaccine, 2020-03-17, Volume 38
Japanese encephalitis (JE) is a mosquito-borne viral infection of the brain that can cause permanent brain damage and death. In the Philippines, efforts are underway to deliver a live attenuated JE vaccine (CD-JEV) to children under five years of age (YOA), who are disproportionately infected. Multiple vaccination strategies are being considered.We conducted a cost-effectiveness analysis comparing three vaccination strategies to the current state of no vaccination from the societal and govern…
Publication
ID32192830Published Date2020-03-17JournalSeminars in cell & developmental biology, 2020-03-17
Lipid droplets (LDs) are versatile organelles with central roles in lipid and energy metabolism in all eukaryotes. They primarily buffer excess fatty acids by storing them as neutral lipids, mainly triglycerides and steryl esters. The neutral lipids form a core, surrounded by a unique phospholipid monolayer coated with a defined set of proteins. Thus, the architecture of LDs sets them apart from all other membrane-bound organelles. The origin of LDs remained controversial for a long time. How…
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Publications: 4,863
Patents: 48
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