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Publication
ID32569132Published Date2020-06-19JournalOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2020-06-19
: Hypothesis: There may be findings peculiar to the temporal bones of children with Down's syndrome (DS). The purpose of this study is to investigate the temporal bone histopathology of the children with DS.Otitis media with effusion is a highly prevalent condition with DS. Knowledge of the volume of the tympanic compartments and the area of the tympanic isthmus might be important to find out the pathogenesis of highly prevalent otitis media with effusion in those patients.We compared the vol…
Publication
ID27075694Published Date2017-01-01JournalThe Laryngoscope, 2017-01-01, Volume 127
In this study, our objective was to histopathologically analyze the peripheral vestibular system in patients with Mondini dysplasia.Comparative human temporal bone study.We assessed the sensory epithelium of the human vestibular system with a focus on the number of type I and type II hair cells, as well as the total number of hair cells. We compared those numbers in our Mondini dysplasia group versus our control group.The loss of type I and type II hair cells in the cristae of the superior, l…
Publication
ID26860231Published Date2016-12-01JournalAuris, nasus, larynx, 2016-12-01, Volume 43
To observe any changes in stria vascularis and cochlear hair cells in patients with syphilis.We examined 13 human temporal bone samples from 8 patients with syphilis (our syphilis group), as well as 12 histopathologically normal samples from 9 age-matched patients without syphilis (our control group). We compared, between the two groups, the mean area of the stria vascularis (measured with conventional light microscopy connected to a personal computer) and the mean percentage of cochlear hair…
Publication
ID27107158Published Date2016-11-01JournalThe Laryngoscope, 2016-11-01, Volume 126
To compare the volume of the epitympanic space, as well as the area of the tympanic isthmus, in human temporal bones with retraction pockets to those with chronic otitis media without retraction pockets and to those with neither condition.Comparative human temporal bone study.We generated a three-dimensional model of the bony epitympanum and measured the epitympanic space. We also compared the area of the tympanic isthmus.The mean total volume of the epitympanum was 40.55 ± 7.14 mm in the ret…
Publication
ID27165677Published Date2016-09-01JournalOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2016-09-01, Volume 155
To evaluate the histopathologic changes of dark, transitional, and hair cells of the vestibular system in human temporal bones from patients with chronic otitis media.Comparative human temporal bone study.Otopathology laboratory.To compare the density of vestibular dark, transitional, and hair cells in temporal bones with and without chronic otitis media, we used differential interference contrast microscopy.In the chronic otitis media group (as compared with the age-matched control group), t…
Publication
ID26573155Published Date2016-09-01JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016-09-01, Volume 273
To the best of our knowledge, histopathologic studies of syphilitic ears have generally focused on hydropic changes; so far, no such studies have investigated peripheral vestibular otopathology using differential interference contrast microscopy, in patients with syphilis. For this study, we examined 13 human temporal bone samples from 8 patients with a history of syphilis. Using conventional light microscopy, we performed qualitative histopathologic assessment. In addition, using differentia…
Publication
ID27050649Published Date2016-06-01JournalOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016-06-01, Volume 37
This study aimed to determine if there are quantitative differences in the neuroepithelium and microvasculature of the saccule between subjects with and without diabetes mellitus (DM).Histopathologic changes that may underlie the association between DM and vestibular dysfunction have not been characterized in humans.Human temporal bones (HTBs) from 39 subjects with DM (n = 16 type I DM [T1DM], n = 23 type II DM [T2DM]) were compared with 40 group age-matched controls. Vessel wall thickness wa…
Publication
ID26309142Published Date2016-03-01JournalThe Laryngoscope, 2016-03-01, Volume 126
To determine if peripheral vestibular otopathology is present in human temporal bones with otosclerosis.Comparative human temporal bone study.Seventy-four human temporal bones from 46 subjects with otosclerosis (mean age of 61 ± 18 years) and 20 within histologically normal limits from 17 subjects (mean age of 59 ± 14 years) were included in this study. Temporal bones with otosclerosis were divided into those with and without endosteal involvement. Using differential interference contrast mic…
Publication
ID26669555Published Date2016-02-01JournalOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016-02-01, Volume 37
To compare histopathologic findings in the cochlea of human temporal bones with versus without intralabyrinthine hemorrhage.Hemorrhagic labyrinthitis can cause sensorineural damage, sudden hearing loss, and vertigo. Yet, to our knowledge, no studies have quantitatively described histopathologic effects of intralabyrinthine hemorrhage on the elements of the cochlea.We analyzed 46 human temporal bone samples from 23 patients with unilateral intralabyrinthine hemorrhage (23 samples from ears wit…
Publication
ID26307578Published Date2016-01-01JournalOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2016-01-01, Volume 154
Dizziness associated with vestibular schwannoma is usually ascribed to retrolabyrinthine mechanisms. The goal of this study was to determine if quantitative peripheral vestibular (labyrinthine) otopathology was present in a series of patients with vestibular schwannoma.Comparative human temporal bone study.Otopathology laboratory.Temporal bones from 12 subjects with unilateral sporadic vestibular schwannoma were included. Based on differential interference contrast microscopy, type I and II v…
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