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Patent
Publication NumberCA 2699856 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2008-09-17Publication Date2019-08-20
A real-time method of detecting the presence and/or amount of a methylated or unmethylated gene of interest in a DNA-containing sample, comprises the steps of: (a) contacting the DNA-containing sample with a reagent which selectively modifies unmethylated cytosine residues in the DNA to produce detectable modified residues but which does not modify methylated cytosine residues (b) amplifying at least a portion of the methylated or unmethylated gene of interest using at least one primer pair, …
Patent
Publication NumberCA 2718092 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2009-03-23Publication Date2019-03-19
The present invention relates to methods and kits for identifying, diagnosing, prognosing, and monitoring cervical cancer. These methods include determining the methylation status or the expression levels of particular genes, or a combination thereof.
Patent
Publication NumberUS 20190032149Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-10-08Publication Date2019-01-31
A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, TFPI2, BNIP3, FOXE1, SYNE1, SOX17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer. Also described are pharmacogenetic methods for determining suitable treatment regimen…
Patent
Publication NumberUS 10053724Filing StatusIssued PatentAvailabilityUnknownFiling Date2015-06-08Publication Date2018-08-21
A real-time method of detecting the presence and/or amount of a methylated or unmethylated gene of interest in a DNA-containing sample, comprises the steps of: (a) contacting the DNA-containing sample with a reagent which selectively modifies unmethylated cytosine residues in the DNA to produce detectable modified residues but which does not modify methylated cytosine residues (b) amplifying at least a portion of the methylated or unmethylated gene of interest using at least one primer pair, …
Patent
Publication NumberEP 2271774 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2009-03-23Publication Date2018-03-07
Patent
Publication NumberBR PI817008 A2Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2008-09-17Publication Date2017-05-16
An oligonucleotide, primer or probe comprises the nucleotide sequences of any of SEQ ID NO. 5, 6, 7, 2, 3, 4, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 25. The oligonucleotides are useful for the detection of the methylation status of a gene, in particular the MAGE-A3 gene. The oligonucleotides are useful in primer pairs, kits and methods for determining the methylation status of the MAGE-A3 gene and for diagnosing cancer, directing therapy and selecting subjects for treatment. The primer o…
Patent
Publication NumberUS 20170121775Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2016-02-09Publication Date2017-05-04
Methods and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. The tools can be assembled into kits or can be used separately. Genes found to be epigenetically silenced in association with lung cancer include ACSL6, ALS2CL, APC2, ARTS-1, BEX1, BMP7, BNIP3, CBR3, CD248, CD44, CHD5, DLK1, DPYSL4, DSC2, EDNRB, EPB41L3, EPHB6, ERBB3, FBLN2, FBN2, FOXL2, GNAS, GSTP1, …
Patent
Publication NumberEP 2198042 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2008-09-11Publication Date2016-11-02
Patent
Publication NumberUS 9371569Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-02-13Publication Date2016-06-21
The present invention relates to methods and kits for identifying, diagnosing, prognosing, and monitoring cervical cancer. These methods include determining the methylation status or the expression levels of particular genes, or a combination thereof.
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