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ID32184168Published Date2020-06-05JournalGene, 2020-06-05, Volume 742
Lysosomal desialylation is the initial step in the degradation of sialo-glycopeptides that is essential for regenerating sialo-glycoconjugates. Neu1 sialidase is the enzyme responsible for the removal of sialic acid in the mammalian lysosome. Although Neu1 sialidases are conserved in fish similar to mammals, their physiological functions remain to be fully understood. Nile tilapia (Oreochromis niloticus) is known to possess two putative Neu1 sialidases (Neu1a and Neu1b) in the genome that may…
Publication
ID32192772Published Date2020-06-04JournalBiochemical and biophysical research communications, 2020-06-04, Volume 526
Osteoclast and osteoblast are essential for proper bone development and remodeling as well as recovery of bone fracture. In this study, we seek chemical compounds that enhance turnover of bone metabolism for promoting bone healing. First, we screen a chemical library which includes 378 compounds by using murine pre-osteoclastic RAW264.7 cells to identify compounds that promote osteoclastic differentiation. We find that two ROCK (Rho-associated coiled-coil kinase) inhibitors, HA-1077 (Fasudil)…
Publication
IDIEEE:8957609Published Date2020-06-01JournalIEEE Transactions on Applied Superconductivity, 2020-06-01, Volume 30
In a high-temperature superconducting (HTS) multi-layer AC cable, each layer of HTS tape is twisted cylindrically and exposed to the AC magnetic field produced by the AC transport current in the other layers. The magnetic field consists of a circumferential magnetic field and a longitudinal magnetic field. The magnetic field of each layer serves as an external magnetic field to the other layers. We measured the AC losses in twisted cylindrical samples comprising single layers of HTS cable tra…
Publication
ID31989254Published Date2020-06-01JournalCell and tissue research, 2020-06-01, Volume 380
Phenotypic changes in culture hamper the identification and characterization of cultured podocytes and parietal epithelial cells of the Bowman's capsule (PECs). We have recently established culture conditions that restore podocytes to their differentiated phenotypes. We compared podocytes and PECs cultured under the same conditions to determine the unique characteristics of the two cell types. Performing this comparison under the same conditions accentuated these differences. Podocytes behave…
Publication
ID32084525Published Date2020-06-01JournalInternational journal of radiation oncology, biology, physics, 2020-06-01, Volume 107
Brain metastases are a common sequelae of breast cancer. Survival varies widely based on diagnosis-specific prognostic factors (PF). We previously published a prognostic index (Graded Prognostic Assessment [GPA]) for patients with breast cancer with brain metastases (BCBM), based on cohort A (1985-2007, n = 642), then updated it, reporting the effect of tumor subtype in cohort B (1993-2010, n = 400). The purpose of this study is to update the Breast GPA with a larger contemporary cohort (C) a…
Publication
ID32085973Published Date2020-06-01JournalJournal of bioscience and bioengineering, 2020-06-01, Volume 129
Among sake yeast strains, Kyokai no. 7 (K7) and its closely related strains (K7 group) are predominantly used because of their excellent brewing properties. In the sake industrial sector, the need for various types of yeast strains is high. Although crossbreeding is an effective method for generating genetic diversity that should result in diverse characteristics, most K7 group strains lack normal sporulation ability, including the ability to undergo meiotic chromosomal recombination, which l…
Publication
IDIEEE:8946769Published Date2020-06-01JournalIEEE Transactions on Applied Superconductivity, 2020-06-01, Volume 30
For magnetic bearings combining multiple cubic superconducting bulks, placement is a crucial factor. In this paper, the magnetic bearing surface constructed by arrangement optimization was composed of eight superconducting cubic bulk units. The combined arrangement of cubic superconducting bulks was determined by optimizing the spatial uniformity of the magnetic bearing's trapped magnetic flux distribution. We constructed a physical model in which a permanent magnet in the form of a floating …
Publication
ID32277943Published Date2020-06-01JournalJournal of neuroscience methods, 2020-06-01, Volume 339
Phosphorylation is the most important post-translational modification of proteins in many cells, including neurons. Phosphoproteomics is a relatively new technique for comprehensively identifying phosphorylation sites in the whole proteome of a given system. We applied this method to developmental neurobiology research to understand the signaling pathways that regulate the mammalian growth cone, which is formed at the tips of developing neurites to ensure accurate neuronal network formation. …
Publication
ID32080029Published Date2020-06-01JournalOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2020-06-01, Volume 41
To test whether the threshold of nerve integrity monitor (NIM) responses during facial nerve decompression surgery can predict the postoperative outcome.Retrospective study.University hospital.Twenty peripheral facial palsy patients who underwent transmastoid decompression surgery.During decompression surgery, thresholds of NIM responses were measured via direct facial nerve stimulation at three sites: the geniculate ganglion (GG), the second genu (2 G), and the stylomastoid foramen.Facial ne…
Publication
ID32278722Published Date2020-06-01JournalNeuroscience, 2020-06-01, Volume 436
The platelet-derived growth factor receptor-α (PDGFRα) principally mediates growth factor signals in oligodendroglial progenitors and is involved in oligodendrogenesis and myelinogenesis in the developing spinal cord. However, the role of PDGFRα in the developing forebrain remains relatively unknown. We established a conditional knockout mouse for the Pdgfra gene (N-PRα-KO) using a Nestin promoter/enhancer-driven Cre recombinase and examined forebrain development. The expression of PDGFRα was…
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Research Grants: 10
Publications: 27,610
Patents: 150
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