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PubMed ID30359575Published Date2018-12-15JournalExperimental cell research, 2018-12-15, Volume 373
Type 2 diabetes mellitus (DM2) follows impaired glucose tolerance in obesity and is frequently associated with hypertension, causing adverse myocardial remodelling and leading to heart failure. The DNA bound protein PARP (poly ADP ribose) polymerase catalyses a post translational modification (polymerization of negatively charged ADP-ribose chains) of nuclear proteins. PARP-1 activation is NAD dependent and takes part in DNA repair and in chromatin remodelling and has a function in transcript…
Publication
PubMed ID28578468Published Date2018-12-01JournalEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society, 2018-12-01, Volume 44
Penetrating cardiac injuries are uncommon and lethal. The objectives of this study are to examine the national profile of cardiac injuries, identify independent predictors of outcome, generate, compare and validate previous predictive models for outcomes. We hypothesized that National Trauma Data Bank (NTDB) given its large number of patients, would validate these models.The NTDB was queried for data on cardiac injuries, using survival as the main outcome measure. Statistical analysis was per…
Publication
PubMed ID30291445Published Date2018-12-01JournalJournal of neural transmission (Vienna, Austria : 1996), 2018-12-01, Volume 125
Hand deformities are well-known abnormalities observed in patients with Parkinson's disease (PD). We determined the frequency and diagnostic accuracy of hand deformities in PD. We studied 44 consecutive patients with PD, 44 age- and gender-matched normal controls and 22 patients with essential tremor (ET). By means of photographs taken in both hands of all participants, the degree of metacarpophalangeal (MCP) joint flexion was quantified by software and by blinded evaluations using a semiquan…
Publication
PubMed ID30177260Published Date2018-12-01JournalThe American journal of the medical sciences, 2018-12-01, Volume 356
Anti-Semitic quotas to restrict access to medical school, graduate medical education and hospital privileges were common in the United States from the 1920s to the 1960s. In Brooklyn, New York, medical education prejudice resulted in violence. In 1916 a Jewish intern at Kings County Hospital, Matthew Olstein, was bound and gagged by Christian interns, put on a train at Grand Central Station, and warned that if he returned he would be thrown in the East River. Olstein died in combat in World W…
Publication
PubMed ID30332893Published Date2018-12-01JournalExpert opinion on biological therapy, 2018-12-01, Volume 18
Psoriasis and psoriatic arthritis are common diseases with significant physical and emotional burden. Several biologics are FDA-approved to treat psoriasis and psoriatic arthritis, though some patients remain refractory to, or have lost response to, therapy and/or cannot tolerate the associated risks and side effects. Bimekizumab is a new biologic that inhibits both IL-17A and IL-17F. It is currently in phase III clinical trials. To date, phase II studies show promise in its ability to rapidl…
Publication
PubMed ID28965136Published Date2018-12-01JournalEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society, 2018-12-01, Volume 44
The wound healing properties of platelet-rich plasma (PRP) gel have been documented in many studies. PRP gel has also become a promising agent for treating surgical site infections. In this study, we investigated the antibacterial activity and wound healing effectiveness of PRP in an animal model of Methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA N315)-contaminated superficial soft tissue wounds.Subcutaneous wounds in Wistar Albino male rats were created by making two cm midli…
Publication
PubMed ID30203110Published Date2018-12-01JournalStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2018-12-01, Volume 194
To report our results of computed tomography-guided interstitial high-dose-rate (HDR) brachytherapy (BRT) in the treatment of patients with recurrent inoperable glioblastoma multiforme (GBM).Between 1995 and 2014, 135 patients were treated with interstitial HDR BRT for inoperable recurrent GBM located within previously irradiated volumes. Patient's median age was 57.1 years (14-82 years). All patients were pretreated with surgery, postoperative external beam radiation therapy (EBRT) and syste…
Publication
PubMed ID30055364Published Date2018-12-01JournalWorld neurosurgery, 2018-12-01, Volume 120
The exact mechanism, incidence, and risk factors for cerebral vasospasm after traumatic intracranial hemorrhage (ICH) continue to be poorly characterized. The incidence of post-traumatic vasospasm (PTV) varies depending on the detection modality.We aimed to shed light on the predictors, associations, and true incidence of cerebral vasospasm after traumatic ICH using digital subtraction angiography (DSA) as the gold standard.We examined a prospectively maintained database of traumatic brain in…
Publication
PubMed ID30311014Published Date2018-12-01JournalClinical rheumatology, 2018-12-01, Volume 37
The above article originally published with an error present in Discussion section and presented correctly in this article. The original article was corrected.
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