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Clinical Trial
Clinical Trial IDNCT02434965Start Date2019-06-01Completion Date2022-01-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to investigate the safety and effectiveness of autologous human placental-derived stem cells (HPDSC) in combination with autologous cord blood in neonates with severe hypoxic-ischemic encephalopathy.
Publication
ID30940550Published Date2019-06-15JournalToxicology letters, 2019-06-15, Volume 308
Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, experimental studies have primarily utilized parenteral routes. Here we used two different modes of oral administration of TMDT and compared the toxic outcomes with two different par…
Publication
ID30706450Published Date2019-05-01JournalBritish journal of haematology, 2019-05-01, Volume 185
Mature (non-anaplastic) T-cell and natural killer (NK)-lymphomas rarely occur in children or adolescents. Due to the low incidence and heterogeneity, information regarding the aetiology, physiopathology and genetics of paediatric mature (non-anaplastic) T/NK-cell lymphoma is lacking. In addition, standard treatments have not yet been established. In the absence of randomised clinical trials, anthracycline-containing regimens are usually considered as the first treatment option, but with disco…
Publication
ID30365406Published Date2019-05-01JournalCardiology in review, 2019-05-01, Volume 27
During spaceflight, the human cardiovascular system undergoes major changes primarily related to the effects of decreased gravitational force, or microgravity, on the human body. These changes present challenges to human adaptation and operation in space. This article reviews the knowledge gained in human experiments in the past half century of spaceflight, and summarizes our knowledge on the effects of short- and long-duration microgravity exposure on cardiovascular physiology and functionin…
Publication
ID30585794Published Date2019-05-01JournalCardiology in review, 2019-05-01, Volume 27
Idiopathic inflammatory myopathies are a group of autoimmune diseases that are characterized by muscle inflammation resulting in elevated muscle enzyme release and distinctive biopsy findings. This group of conditions includes polymyositis, dermatomyositis, inclusion body myositis, and necrotizing autoimmune myopathy. Although they have many similarities, the inflammatory myopathies differ in their clinical, pathological, and treatment realms. Extramuscular manifestations may involve many org…
Publication
ID30875634Published Date2019-05-01JournalEpilepsy research, 2019-05-01, Volume 152
Epileptic spasms during infancy (infantile spasms) represent a serious treatment and social problem despite their rare occurrence. Current treatments include hormonal therapy (adrenocorticotropin-ACTH or corticosteroids) or vigabatrin (per se or in the combination). These treatments are partially effective and with potentially significant adverse effects. Thus, the search for new effective drugs is warranted. We tested efficacy of a novel fusion peptide AQB-565 developed by Aequus Biopharma i…
Publication
ID30391454Published Date2019-05-01JournalJournal of clinical anesthesia, 2019-05-01, Volume 54
Abstract not available
Publication
ID29897572Published Date2019-05-01JournalNeurosurgery, 2019-05-01, Volume 84
Pituitary adenomas are among the most common primary brain tumors. Recently, overlapping surgery has been curbed in many institutions because of the suggestion there might be more significant adverse events, despite several studies showing that complication rates are equivalent.To assess complications and costs associated with overlapping surgery during the transsphenoidal resection of pituitary adenomas.A single-center, retrospective cohort study was performed to evaluate the cases of patien…
Publication
ID30740766Published Date2019-05-01JournalAmerican journal of hematology, 2019-05-01, Volume 94
Carfilzomib and dexamethasone (Kd) has significant activity in relapsed and refractory multiple myeloma. Kd has not previously been evaluated in newly diagnosed multiple myeloma (NDMM). We report a single-arm phase 2 study of 72 patients with NDMM to evaluate the efficacy and tolerability of Kd induction. Carfilzomib was administered in two dosing cohorts with dosing of 20/45 mg/m in the first 25 patients and 20/56 mg/m in the subsequent 47 patients. Carfilzomib was administered on days 1, 2,…
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