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Publication
ID32147436Published Date2020-06-05JournalEuropean journal of pharmacology, 2020-06-05, Volume 876
Hepatic ischemia/reperfusion (I/R) injury is a common complication in the clinical setting. Our previous study has shown that connexin 32 (Cx32) plays a major role in renal I/R injury; however, the role of Cx32 in hepatic I/R injury remains unknown. Liver tissue and serum samples from patients undergoing orthotopic liver transplantation (OLT) were used to evaluate the function of Cx32 in OLT post-reperfusion injury. Then, partial hepatic ischemia was established in global Cx32 knockout mice a…
Publication
ID32171792Published Date2020-06-05JournalEuropean journal of pharmacology, 2020-06-05, Volume 876
Inhibition of Aβ aggregation and neurotoxicity has been developed as an attractive therapeutic strategy to combat Alzheimer's disease (AD). Bis(propyl)-cognitin (B3C) is a multifunctional dimer derived from tacrine. Herein, the anti-aggregation and disassembly effects of B3C on Aβ, together with the neuroprotective effects and underlying mechanisms of B3C against Aβ-induced neurotoxicity were investigated in silico, in vitro and in vivo. Data from Thioflavin-T fluorescence and atomic force mi…
Publication
ID32169789Published Date2020-06-05JournalJournal of pharmaceutical and biomedical analysis, 2020-06-05, Volume 185
A rapid and sensitive liquid chromatography-tandem mass spectrometric method was developed and validated for the determination of HA15, an emerging anticancer compound targeting GSPA5/BIP delivered by dissolvable polymeric microneedles. The linear range of quantification for HA15 was 2.5-1000 ng/ml in plasma and tissue homogenate and the limit of detection and lower limit of quantification are 1 and 2.5 ng/ml, respectively. The inter- and intra-day accuracy and precision were within the accep…
Publication
ID32044633Published Date2020-06-05JournalJournal of hazardous materials, 2020-06-05, Volume 391
Nanoplastics (NPs) are emerging pollutants which can adsorb large amounts of hydrophobic organic compounds (HOCs) and be ingested by aquatic organisms. NPs interact with dissolved organic matter (DOM) and result in significant impacts on the bioaccumulation of HOCs in the actual environment. For the first time, the joint effects of two complex matrices on the bioaccumulation of polycyclic aromatic hydrocarbons (PAHs) to Daphnia magna (D. magna) were studied by modeling calculation. The comple…
Publication
ID32062344Published Date2020-06-05JournalJournal of hazardous materials, 2020-06-05, Volume 391
In this study we synthesized a triazine-formaldehyde phenolic resin as a nitrogen-containing resol (N-resol) through the condensation of 2,4,6-tris(4-hydroxyphenyl)triazine and formaldehyde. We then used this N-resol as a carbon and nitrogen atom source, mixing it with a diblock copolymer of PEO-b-PCL as the soft template, for the direct synthesis of N-doped mesoporous carbons. Interestingly, the self-assembled N-resol/PEO-b-PCL blends underwent a mesophase transition from cylinder to gyroid …
Publication
ID32087880Published Date2020-06-07JournalJournal of chromatography. A, 2020-06-07, Volume 1620
A high sampling rate, good stability, high throughput masking fluorescence detection system with easy positioning of each channel for capillary array electrophoresis was prepared and studied. A special mask combined with convex lenses was designed to modulate signals, without using any extra device to position each channel. The signal of each channel was detected by a photomultiplier tube, classified and saved by software. The design was used to evidently reduce the rotational vibration of op…
Publication
ID31901003Published Date2020-06-02JournalAngewandte Chemie (International ed. in English), 2020-06-02, Volume 59
Cell-free enzymatic catalysis (CFEC) is an emerging biotechnology that enable the biological transformations in complex natural networks to be imitated. This biomimetic approach allows industrial products such as biofuels and biochemical to be manufactured in a green manner. Nevertheless, the main challenge in CFEC is the poor stability, which restricts the effectiveness and lifetime of enzymes in sophisticated applications. Immobilization of the enzymes within solid carriers is considered an…
Publication
IDDOI:10.1115/1.4045362Published Date2020-06-01JournalJournal of Electronic Packaging, 2020-06-01, Volume 142
Abstract This study successfully established a strip warpage simulation model that is applied to the wire bonding process, and explored the effects of structural designs, material types, and processes such as molding, post and mold cure (PMC), pretreatment, and ball mounts on the strip warpage. The error between the experimental values and the simulation values is less than 13.7%. In addition, the Taguchi method is used to determine that the key factors affecting the strip warpage are the die…
Publication
ID32334274Published Date2020-06-01JournalPsychiatry research, 2020-06-01, Volume 288
Cognitive impairment is one of the core symptoms of schizophrenia, and patients with schizophrenia are at increased risk of metabolic syndrome (MS). However, the role of MS in cognitive impairment of schizophrenia is not established. This study investigated the correlation between neurocognitive, social cognitive performance and MS with schizophrenia. One hundred and fifty eight (158) schizophrenia patients were divided into 3 groups with ① normal metabolism, ② metabolic disorder (only meetin…
Publication
ID32119935Published Date2020-06-01JournalExperimental neurology, 2020-06-01, Volume 328
S-Nitrosoglutathione (GSNO) is a nitric oxide donor that has been investigated for neuroprotective and neuro-recovery effect. We aimed to conduct a systematic review on the published literatures using GSNO in both pre-clinical and clinical stroke studies.We searched PubMed up to June 30, 2019, using the following keywords: S-Nitrosoglutathione, GSNO, stroke, cerebrovascular, carotid arteries, middle cerebral artery, and middle cerebral artery occlusion. Only studies published in the English l…
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Patents: 2,102
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