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Research Institution (4.4K)University (1.5K)Hospital (350)Company (313)Foundation (30)Investor (6)
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Clinical Trial
Clinical Trial IDNCT04314648Start Date2020-04-01Completion Date2021-02-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Despite high prevalence, few hospitalized inpatients with opioid or alcohol use disorders (OAUDs) receive evidence-based treatments while in the hospital or get linked with appropriate follow-up care, leading to poor clinical outcomes and high readmission rates and costs. The purpose of this study is to evaluate whether a physician and care manager with addiction expertise, both members of the Substance Abuse Treatment and Recovery Team (START), can help improve initiation of treatment in the…
Clinical Trial
Clinical Trial IDNCT03869671Start Date2020-04-01Completion Date2022-03-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
People who inject drugs (PWID) experience high risk of HIV acquisition. Antiretroviral pre-exposure prophylaxis (PrEP) is an efficacious biomedical HIV prevention strategy for high risk HIV-uninfected individuals including PWID, yet uptake has been low in this population and uptake and adherence interventions have not been developed or tested. Drawing from formative qualitative research, the overall goal of this project is to develop an intervention to promote PrEP uptake and adherence among …
Clinical Trial
Clinical Trial IDNCT03555396Start Date2020-04-01Completion Date2023-06-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The fastest growing HIV epidemics globally are driven by injection drug use, but only a small percentage of HIV-positive people who inject drugs (PWID) have achieved viral suppression. The proposed project will adapt a couple-based antiretroviral therapy (ART) adherence intervention for PWID and assess the feasibility and acceptability of conducting dried blood spot testing to objectively measure ART adherence as part of an intervention in a clinical setting. This project advances HIV interve…
Clinical Trial
Clinical Trial IDNCT04109118Start Date2020-04-01Completion Date2020-12-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
The proposed study is a clinical trial, designed to pilot test a Distress Tolerance-Benzodiazepine Discontinuation (DT-BD) intervention for patients on opioid agonist therapy who currently use benzodiazepines, compared to a Relaxation Therapy (RT) control condition. Both are adjunctive psychosocial interventions in people seeking to discontinue (BZD) use. The goal of the study is to assess the applicability and feasibility of these interventions through treatment retention and qualitative int…
Clinical Trial
Clinical Trial IDNCT04191278Start Date2020-04-01Completion Date2022-07-01PhasePhase 4Study TypeInterventionalStatusNot yet recruiting
Cigarette smoking remains highly prevalent among persons living with HIV (PLWH). Quitting smoking can have important health benefits for this population. However, PLWH have historically had a difficult time quitting smoking. This is likely due, at least in part, to poor medication adherence. Poor adherence to medication is a well-documented issue among PLWH. Research shows that not taking smoking cessation medications as prescribed can limit their treatment effectiveness. Improving adherence …
Clinical Trial
Clinical Trial IDNCT04308694Start Date2020-04-01Completion Date0031-06-29PhaseEarly Phase 1Study TypeInterventionalStatusNot yet recruiting
The overarching goal of this pilot study is to explore the feasibility, acceptability, and patient/provider satisfaction of pharmacy-based administration and dispensing of methadone for opioid use disorder. The results gained will inform the development of a future multisite randomized clinical trial.
Clinical Trial
Clinical Trial IDNCT03837379Start Date2020-04-01Completion Date0031-02-27PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The goal of this work is to develop, systematically evaluate, and clinically test an integrated cessation intervention comprised of a depression-specific Behavioral Activation (BA) for cessation mobile app ("Goal2Quit") packaged with nicotine replacement therapy (NRT) sampling. This integrated intervention will address the need for an easily disseminable, evidence-based, depression-specific cessation intervention for delivery via primary care.
Publication
ID32205443Published Date2020-03-23JournalProceedings of the National Academy of Sciences of the United States of America, 2020-03-23
We recently reported that social choice-induced voluntary abstinence prevents incubation of methamphetamine craving in rats. This inhibitory effect was associated with activation of protein kinase-Cδ (PKCδ)-expressing neurons in central amygdala lateral division (CeL). In contrast, incubation of craving after forced abstinence was associated with activation of CeL-expressing somatostatin (SOM) neurons. Here we determined the causal role of CeL PKCδ and SOM in incubation using short-hairpin RN…
Clinical Trial
Clinical Trial IDNCT04316741Start Date2020-05-01Completion Date2021-07-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The purpose of the study is to develop and test social media interventions to help young people increase well-being and reduce risky behaviors. The study will help researchers learn about ways to deliver wellness information in a way that is appealing and helpful to young people who use Snapchat.
Clinical Trial
Clinical Trial IDNCT04124432Start Date2020-05-01Completion Date2022-01-01PhasePhase 1Study TypeInterventionalStatusNot yet recruiting
This study will evaluate the individual and interactive pharmacokinetic and pharmacodynamic effects of smoked cannabis and nicotine.
We found 4,495 documents that match your Search
Research Grants: 2,469
Publications: 126
Patents: 4
Clinical Trials: 1,896

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