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Patent
Publication NumberUS 10583441Filing StatusIssued PatentAvailabilityUnknownFiling Date2015-09-11Publication Date2020-03-10
A liquid injection port including a liquid input block defining a liquid input conduit; a compression block adapted to mate with the liquid input block; and a septum including a deformable material mounted in a septum retainer, the septum defining a central perforation, and forming a seal between the liquid input block and the compression block. The septum defines a conical deformation toward the liquid input conduit. A method for delivering fluid from a pipette tip includes a) introducing th…
Patent
Publication NumberUS 10294516Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-01-16Publication Date2019-05-21
Methods for enhancing the binding of oligonucleotide probes to DNA and RNA are disclosed. The methods make use of thermodynamic and kinetic effects to reduce probe mismatches and failure of complementary probes to bind to DNA and RNA templates. Mapping and sequencing of the probed DNA and RNA samples are contemplated herein.
Patent
Publication NumberEP 2435185 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2009-09-03Publication Date2019-02-27
Patent
Publication NumberEP 2622098 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2011-09-26Publication Date2018-08-29
Patent
Publication NumberUS 9914966Filing StatusIssued PatentAvailabilityUnknownFiling Date2013-12-13Publication Date2018-03-13
The invention relates to devices and methods for hybridization assisted sequencing of biomolecule analytes in nanopores, nano-channels and micro-channels. An alternating current signal may be employed to achieve a significantly improved signal-to-noise ratio, thereby enhancing system performance.
Patent
Publication NumberEP 2201136 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2008-10-01Publication Date2017-12-06
Patent
Publication NumberUS 9719980Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-07-15Publication Date2017-08-01
Devices and methods for detecting the length of analytes and/or sequencing analytes are provided in which two or more electrical signals are obtained as an analyte traverses a fluidic channel. Detection of the relative position of probes hybridized to a biopolymer and/or the length of the analyte (e.g., a biopolymer) does not rely on the absolute time between detection events of a given electrical signal to determine a distance associated with the biopolymer. Instead, multiple signals are obt…
Patent
Publication NumberUS 9702003Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-08-26Publication Date2017-07-11
A sequencing method is presented in which a biomolecule is hybridized with a specially chosen pool of different probes of known sequence which can be electrically distinguished. The different probe types are tagged such that they can be distinguished from each other in a Hybridization Assisted Nanopore Sequencing (HANS) detection system, and their relative positions on the biomolecule can be determined as the biomolecule passes through a pore or channel. The methods eliminate, resolve, or gre…
Patent
Publication NumberUS 9650668Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-03-05Publication Date2017-05-16
Devices for detecting an analyte are provided. Devices for voltage sensing of analytes may comprise a plurality of fluidic channels defined in a substrate, each channel having a pair of sensing electrodes disposed in or adjacent to the fluidic channel and defining a detection volume for sensing voltage therein. At least one pair of electromotive electrodes for applying potential along at least one fluidic channel is provided as well.
We found 57 documents that match your Search
Research Grants: 2
Patents: 50
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