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ID31371201Published Date2019-12-06JournalJournal of chromatography. A, 2019-12-06, Volume 1607
Approaches to simulate peak time and intensity profiles of compounds in comprehensive two dimensional gas chromatography (GC × GC) were developed, and which are demonstrated for separation of a mixture of saturated and unsaturated fatty acid methyl esters (FAME) using a range of column sets. The simulation of first and second dimension time (t and t) of FAME relies on use of a Gibbs energy additivity approach to correlate with the structures of FAME. First and second dimension peak standard d…
Publication
ID31422317Published Date2019-12-10JournalThe Science of the total environment, 2019-12-10, Volume 695
Mumps remains a major global public health problem. Many studies have explored the relationship between meteorological factors and mumps, few have comprehensively explored such associations considering nonlinear relationship, delayed effects and collinearity in order to more accurately estimate them. This study aims to explore the relationship between meteorological factors and mumps in consideration of nonlinearity, delayed effects and collinearity.We collected daily reported mumps cases and…
Publication
ID31771472Published Date2019-12-04JournalProceedings. Biological sciences, 2019-12-04, Volume 286
The observed variation in the body size responses of endotherms to climate change may be explained by two hypotheses: the size increases with climate variability () and the size shrinks as mean temperatures rise (). Across 82 Australian passerine species over 50 years, shrinking was associated with annual mean temperature rise exceeding 0.012°C driven by rising winter temperatures for arid and temperate zone species. We propose to explain this response. However, where average summer temperatu…
Publication
ID31690908Published Date2019-12-04JournalChemical communications (Cambridge, England), 2019-12-04, Volume 55
The structural, magnetic and Mössbauer spectral properties of a double salt, mixed-valent material, [Fe(3,5-MeTPM)(TPM)][Fe(azp)]ClO·2MeCN, 1, reveal spin transitions occur at both the metal sites, with hysteresis, indicative of 1 being a double spin crossover material.
Publication
ID31752637Published Date2019-12-03JournalJournal of the American Heart Association, 2019-12-03, Volume 8
Background The failure of cholesteryl ester transfer protein inhibitor torcetrapib was associated with an off-target increase in plasma aldosterone. We sought to evaluate the impact of evacetrapib on plasma aldosterone level and determine the association between plasma aldosterone level and major adverse cardiovascular events among patients with stable high-risk vascular disease enrolled in the ACCELERATE (Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition With Ev…
Publication
ID31622078Published Date2019-12-02JournalACS infectious diseases, 2019-12-02
The mechanism of action of ozonide antimalarials involves activation by intraparasitic iron and the formation of highly reactive carbon-centered radicals that alkylate malaria parasite proteins. Given free intraparasitic heme is generally thought to be the iron source responsible for ozonide activation and its likely close proximity to the activated drug, we investigated heme as a possible molecular target of the ozonides. Using an extraction method optimized for solubilization of free heme, …
Publication
ID31786973Published Date2019-12-02JournalHypertension (Dallas, Tex. : 1979), 2019-12-02
Current cardiovascular pharmacotherapy targets maladaptive overactivation of the renin-angiotensin-aldosterone system (RAAS), which occurs throughout the continuum of cardiovascular disease spanning from hypertension to heart failure with reduced ejection fraction. Over the past 16 years, 4 prospective, randomized, placebo-controlled clinical trials using candesartan, perindopril, irbesartan, and spironolactone in patients with heart failure with preserved ejection fraction (HFpEF) failed to …
Publication
ID31790146Published Date2019-12-02JournalBioinformatics (Oxford, England), 2019-12-02
No rigorous statistical tests for detecting point-group symmetry in 3D charge density maps obtained by electron microscopy and related techniques have been developed.We propose a method for determining the point-group symmetry of 3D charge density maps obtained by electron microscopy (EM) and related techniques. Our ab initio algorithm does not depend on atomic coordinates but utilizes the density map directly. We validate the approach for a range of publicly available single-particle cryo-EM…
Publication
ID31556460Published Date2019-12-02JournalThe EMBO journal, 2019-12-02, Volume 38
Estrogen receptor alpha (ERα) activity is associated with increased cancer cell proliferation. Studies aiming to understand the impact of ERα on cancer-associated phenotypes have largely been limited to its transcriptional activity. Herein, we demonstrate that ERα coordinates its transcriptional output with selective modulation of mRNA translation. Importantly, translational perturbations caused by depletion of ERα largely manifest as "translational offsetting" of the transcriptome, whereby a…
Publication
ID30811730Published Date2019-12-02JournalAngewandte Chemie (International ed. in English), 2019-12-02, Volume 58
Two-dimensional nanosheets have shown great potential for separation applications because of their exceptional molecular transport properties. Nanosheet materials such as graphene oxides, metal-organic frameworks, and covalent organic frameworks display unique, precise, and fast molecular transport through nanopores and/or nanochannels. However, the dimensional instability of nanosheets in harsh environments diminishes the membrane performance and hinders their long-term operation in various …
We found 59,963 documents that match your Search
Research Grants: 175
Publications: 57,494
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