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Publication
ID31724747Published Date2020-02-15JournalCancer, 2020-02-15, Volume 126
To the authors' knowledge, end-of-life (EOL) care outcomes among adolescents and young adults (AYAs) with cancer who are living in poverty remain poorly understood. The primary aim of the current study was to examine the effect of poverty on EOL care for AYA patients with cancer.The authors conducted a multisite, retrospective study of AYA patients with cancer aged 15 to 39 years who died between January 2013 and December 2016 at 3 academic sites. Medical record-based EOL care outcomes includ…
Publication
ID31843233Published Date2020-02-15JournalThe American journal of cardiology, 2020-02-15, Volume 125
The impact of atrial fibrillation (AF) catheter ablation versus chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1,070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients who underwent AF catheter ablation were matched to patients treated with only antiarrhyth…
Publication
ID31870495Published Date2020-02-15JournalBiological psychiatry, 2020-02-15, Volume 87
Since the development of cellular and myelin stains, anatomy has formed the foundation for understanding circuitry in the human brain. However, recent functional and structural studies using magnetic resonance imaging have taken the lead in this endeavor. These innovative and noninvasive approaches have the advantage of studying connectivity patterns under different conditions directly in the human brain. They demonstrate dynamic and structural changes within and across networks linked to nor…
Publication
ID31879207Published Date2020-02-15JournalBioorganic & medicinal chemistry letters, 2020-02-15, Volume 30
Transmembrane AMPA receptor regulatory proteins (TARPs) are a recently discovered family of proteins that modulate AMPA receptors activity. Based on a potent and selective TARP subtype γ-8 antagonist, 6-(methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one (compound 9), we perform the radiosynthesis of its C-isotopologue 1 and conduct preliminary PET evaluation to test the feasibility of imaging TARP γ-8 dependent receptors in vivo.
Publication
ID31740339Published Date2020-02-15JournalNeuroImage, 2020-02-15, Volume 207
Large-scale cortical networking patterns have been established based on the correlation of slow fluctuations of resting fMRI signals. However, the electrophysiological mechanism of cortical networking remained to be elucidated. With large-scale human ECoG recording, we developed a novel approach for functional network parcellation on the basis of probabilistic co-activation of cortical sites in spatio-temporal microstates. The parcellated networks were verified by electrical cortical stimulat…
Publication
ID31818770Published Date2020-02-15JournalJournal of affective disorders, 2020-02-15, Volume 263
The ADHD Self Report Scale is a self-report measure that assesses attentional problems. We sought to validate the ASRS by establishing neural correlates using functional magnetic imaging in healthy controls and individuals with bipolar disorder (BD), who commonly exhibit attentional problems.ASRS questionnaires and functional MRI data in conjunction with the Multi-source Interference Task (MSIT) were collected from 36 healthy control and 36 BD participants. We investigated task specific chang…
Publication
ID31812225Published Date2020-02-15JournalThe American journal of cardiology, 2020-02-15, Volume 125
The residual risk of ventricular arrhythmia (VA) after cardiac resynchronization therapy (CRT) implantation in patients with nonischemic cardiomyopathy (NICM) remains difficult to evaluate. The impact of left ventricular (LV) wall thickness (WT) measured using computed tomography (CT) on the occurrence of VA after CRT implantation has never been investigated. In this pilot study, we examined the association of LV WT and the occurrence of VA in NICM patients receiving CRT. Thirty three patient…
Publication
ID31747077Published Date2020-02-15JournalCancer, 2020-02-15, Volume 126
The current study was conducted to evaluate the efficacy and safety of pembrolizumab-mediated programmed cell death protein 1 inhibition plus radiotherapy (RT) in patients with metastatic triple-negative breast cancer who were unselected for programmed death-ligand 1 expression.The current study was a single-arm, Simon 2-stage, phase 2 clinical trial that enrolled a total of 17 patients with a median age of 52 years (range, 37-73 years). An RT dose of 3000 centigrays (cGy) was delivered in 5 …
Publication
ID31969271Published Date2020-02-15JournalJournal of affective disorders, 2020-02-15, Volume 263
Self-blame following bereavement has been implicated in the development of post-loss psychopathology. However, prior studies have not distinguished between the emotions of shame versus guilt. This study examined the cross-sectional associations among bereavement-related shame, bereavement-related guilt, and two mental disorders that commonly arise after bereavement: complicated grief and depression. In addition, exploratory analyses examined the associations between bereavement-related pride …
Publication
ID31714597Published Date2020-02-15JournalCancer, 2020-02-15, Volume 126
Early detection of ovarian cancer could significantly improve patient outcomes. Cancer antigen 125 (CA 125) is elevated in sera from approximately 60% of patients with early-stage (I/II) disease. Sensitivity might be improved through the combination of CA 125 with other biomarkers. Among potential biomarkers, antigen-autoantibody (Ag-AAb) complexes have received relatively little attention.Luminex-based immunoassays were used to measure human epididymis protein 4 (HE4), anti-HE4 autoantibody,…
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Research Grants: 27,046
Publications: 96,377
Patents: 12,374
Clinical Trials: 4,957
Web Documents: 247

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