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ID29438767Published Date2020-03-01JournalJournal of the American Academy of Dermatology, 2020-03-01, Volume 82
Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management.We now present results from a subsequent Delphi consensus to broaden the generalizability of the recommendations.A preliminary survey, based on the European Dermatology Forum and the European Academy of Dermatology and Venereology guidelines, was sent to a panel of international experts to determine the leve…
Publication
ID31729105Published Date2020-03-01JournalHuman brain mapping, 2020-03-01, Volume 41
In social interactions, each individual's brain drives an action that, in turn, elicits systematic neural responses in their partner that drive a reaction. Consequently, the brain responses of both interactants become temporally contingent upon one another through the actions they generate, and different interaction dynamics will be underpinned by distinct forms of between-brain coupling. In this study, we investigated this by "performing functional magnetic resonance imaging on two individua…
Publication
ID31926435Published Date2020-03-01JournalEnvironment international, 2020-03-01, Volume 136
In animals, retinoic acids (RAs), one of the main derivatives of vitamin A, are crucial for a variety of physiological processes. RAs, including all-trans-RA, 9-cis-RA, 13-cis-RA, and their corresponding metabolites (i.e., all-trans-4-oxo-RA, 9-cis-4-oxo-RA and 13-cis-4-oxo-RA) can be excreted through urination from humans and animals. Sewage treatment plants (STPs) are a significant source of RAs and 4-oxo-RAs into aquatic environments. RAs and 4-oxo-RAs can be identified and quantified by u…
Publication
ID31816395Published Date2020-03-01JournalMolecular phylogenetics and evolution, 2020-03-01, Volume 144
Wood mice of the genus Hylomyscus, are small-sized rodents widely distributed in lowland and montane rainforests in tropical Africa, where they can be locally abundant. Recent morphological and molecular studies have increased the number of recognized species from 8 to 18 during the last 15 years. We used complete mitochondrial genomes and five nuclear genes to infer the number of candidate species within this genus and depict its evolutionary history. In terms of gene sampling and geographic…
Publication
ID31631728Published Date2020-03-01JournalLeukemia & lymphoma, 2020-03-01, Volume 61
MYC was found to be involved in many germinal center derived lymphomas, and more recently in the histological transformation of indolent mature B-cell malignancies, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL) and mucosa-associated lymphoid tissue lymphoma (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). Pathological MYC activity gain in lymphomas is able to overcome its regulation by repressors, which leads to bypassing the affinity-based selection of B-cel…
Publication
ID32016446Published Date2020-03-01JournalMolecular medicine reports, 2020-03-01, Volume 21
Oocyte maturation is essential for proper fertilization, embryo implantation and early development. While the physiological conditions of these processes are relatively well‑known, its exact molecular mechanisms remain widely undiscovered. Oocyte growth, differentiation and maturation are therefore the subject of scientific debate. Precious literature has indicated that the oocyte itself serves a regulatory role in the mechanisms underlying these processes. Hence, the present study performed …
Publication
ID31855845Published Date2020-03-01JournalBlood cells, molecules & diseases, 2020-03-01, Volume 81
Diamond-Blackfan anemia (DBA) is a rare congenital erythroid aplasia, underlied by haploinsufficient mutations in genes coding for ribosomal proteins (RP) in approximately 70% of cases. DBA is frequently associated with somatic malformations, endocrine dysfunction and with an increased predisposition to cancer. Here we present clinical and genetic characteristics of 62 patients from 52 families enrolled in the Czech and Slovak DBA Registry. Whole exome sequencing (WES) and array comparative g…
Publication
ID31848075Published Date2020-03-01JournalTicks and tick-borne diseases, 2020-03-01, Volume 11
Wild rodents are an important source of the tick-borne pathogens Coxiella burnetii and Francisella tularensis. The aim of our study was to assess the prevalence of antibodies and possible coexistence of these pathogens in wild small mammals from three localities in the Czech Republic. A total of 614 wild small mammals (324 Apodemus flavicollis, 145 Myodes glareolus, 50 Sorex araneus, 48 A. sylvaticus, 40 A. agrarius, six Microtus arvalis and one Talpa europaea) were trapped between 2012 and 2…
Publication
ID31763708Published Date2020-03-01JournalEuropean journal of haematology, 2020-03-01, Volume 104
Progress in multiple myeloma treatment allows patients to achieve deeper responses, for which the assessment of minimal residual disease (MRD) is critical. Typically, bone marrow samples are used for this purpose; however, this approach is site-limited. Liquid biopsy represents a minimally invasive and more comprehensive technique that is not site-limited, but equally challenging.While majority of current data comes from short-term studies, we present a long-term study on blood-based MRD moni…
Publication
ID31812591Published Date2020-03-01JournalTicks and tick-borne diseases, 2020-03-01, Volume 11
DNA methylation at the fifth position of cytosine (5mC) and at the sixth position of adenine (6 mA) plays an important role in the regulation of the gene expression and, in eukaryotes, is essential for normal development. For Ixodes ricinus, the most common European arthropod vector of human and animal pathogens, the DNA methylation profile and the role of DNA methylation in tick development are still under discussion. Our goal was to analyze the status of I. ricinus DNA methylation at differ…
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Publications: 8,523
Patents: 8
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