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Patent
Publication NumberUS 10723773Filing StatusIssued PatentAvailabilityUnknownFiling Date2018-11-07Publication Date2020-07-28
Disclosed are new recombinant isoforms of human-like lubricin or PRG4 glycoprotein having outstanding lubrication properties and a novel glycosylation pattern, and methods for their manufacture at high levels enabling commercial production.
Patent
Publication NumberUS 20200215156Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-11-21Publication Date2020-07-09
Disclosed are compositions and methods involving the use of PRG4 protein, also known as lubricin, to mechanically inhibit biological processes involving cell motility and adhesion. The methods and compositions may be used to develop a variety of specific therapies and compositions, often exploited through surgical procedures, where development of the pathology involves one or more of the following modes of action: 1) the passage of cells from one body compartment to another, 2) adherence of m…
Patent
Publication NumberWO 2019246522 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-06-21Publication Date2019-12-26
The application relates to uses of the proteoglycan 4 protein, also known as lubricin, in wound healing and tissue regeneration, reducing scar formation, and promoting angiogenesis.
Patent
Publication NumberUS 10500250Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-11-25Publication Date2019-12-10
Disclosed are compositions and methods involving the use of PRG4 protein, also known as lubricin, to mechanically inhibit biological processes involving cell motility and adhesion. The methods and compositions may be used to develop a variety of specific therapies and compositions, often exploited through surgical procedures, where development of the pathology involves one or more of the following modes of action: 1) the passage of cells from one body compartment to another, 2) adherence of m…
Patent
Publication NumberUS 10500251Filing StatusIssued PatentAvailabilityUnknownFiling Date2018-08-22Publication Date2019-12-10
Disclosed are compositions and methods involving the use of PRG4 protein, also known as lubricin, to mechanically inhibit biological processes involving cell motility and adhesion. The methods and compositions may be used to develop a variety of specific therapies and compositions, often exploited through surgical procedures, where development of the pathology involves one or more of the following modes of action: 1) the passage of cells from one body compartment to another, 2) adherence of m…
Patent
Publication NumberJP 2019189657 AFiling StatusPatent ApplicationAvailabilityUnknownFiling Date2019-08-07Publication Date2019-10-31
To provide compositions and methods involving the use of PRG4 protein.SOLUTION: The methods and compositions may be used to develop a variety of specific therapies and compositions, often exploited through surgical procedures, where development of the pathology involves one or more of the following modes of action: 1) the passage of cells from one body compartment to another, 2) adherence of macrophages to substrates such as fibrin or exposed extracellular matrix, 3) binding of platelets to f…
Patent
Publication NumberUS 10383796Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-08-14Publication Date2019-08-20
The present invention relates to the uses of the protein PRG4 and therapeutic modulation thereof. In particular, the present invention relates compositions and methods utilizing PRG4 and therapeutic modulation thereof, including, use as a surgical lubricant, use in a treatment for prevention or reduction of post-surgical adhesions, use in a treatment for oral ulcerations, use as an athletic lubricating patch, use as a dermal filler, use in a treatment for dry mouth, use in a drug delivery met…
Patent
Publication NumberJP 2019048824 AFiling StatusPatent ApplicationAvailabilityUnknownFiling Date2018-10-25Publication Date2019-03-28
To provide uses of protein PRG4 and therapeutic modulation effect thereof.SOLUTION: An oral care composition for improving oral cavity boundary lubrication comprises an effective amount or effective concentration of an isolated or purified PRG4 formulated in: an aqueous, osmotically balanced salt solution; multiphasic emulsion; gel; liquid; cream; ointment; spray; paste; viscous solution; slow-release device; lozenge; or gum. The effective amount or effective concentration of the isolated or …
Patent
Publication NumberAU 2019201478 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-03-04Publication Date2019-03-28
Abstract Disclosed are new recombinant isoforms of human-like lubricin or PRG4 glycoprotein having outstanding 5 lubrication properties and a novel glycosylation pattern, and methods for their manufacture at high levels enabling commercial production. C:\NRPortbl\GHMatters\MICHELES\10851753_1.docx 19/11/18 WV40 prcnmohn Re Ovgin . ... ReprrOr
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