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Patent
Publication NumberUS 20200032337Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-03-11Publication Date2020-01-30
Methods and compositions for the detection of single nucleotide polymorphisms in a sample are provided. The methods and compositions are employed to determine whether the subject has autism spectrum disorder (ASD), is likely to develop ASD, or to classify a subject as having a particular ASD subtype. In one method of the invention, a sample is probed for one or more SNPs in Table 1, Table 2, Table 3, Table 6 or Table 7 at the nucleic acid level by performing a polymerase chain reaction (PCR) …
Patent
Publication NumberUS 20190247326Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-09-19Publication Date2019-08-15
The present invention provides methods related to Wolf-Hirschhom syndrome (WHS), in particular to a 197 kbp chromosomal deletion useful for selecting a patient for anti-seizure therapy (e.g., cannabidiol, vitamin B6, and butyrate), for selecting a particular anti-seizure therapy, and for predicting the response of a subject to a particular anti-seizure therapy.
Patent
Publication NumberUS 20180230542Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-12-21Publication Date2018-08-16
Methods are disclosed for generating and isolating an informative content repository of respiratory related biomarkers to accurately determine whether an individual has normal or abnormal pulmonary function. Specifically, methods are directed to determination of whether individuals have chronic obstructive pulmonary disease, and if so, whether the affected individuals experience rapid long decline or slow lung decline as a result of COPD. Also disclosed is an informative content repository of…
Patent
Publication NumberUS 9945872Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-07-03Publication Date2018-04-17
Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rate…
Patent
Publication NumberWO 2018057484 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-09-19Publication Date2018-03-29
Review daily docket and provide responses for clearance; including reviewing records and files as needed; review docketing related confirmation emails of foreign agent correspondence for accuracy; forwarding emails to attorney/secretary teams for substantive actions.
Patent
Publication NumberUS 20180073075Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-09-22Publication Date2018-03-15
The technology provided herein relates to the SNPs identified as described herein, both singly and in combination, as well as to the use of these SNPs, and others in linkage disequilibrium with these SNPs, for diagnosis, prediction of clinical course, and/or treatment response for pulmonary disease such as COPD, development of new treatments for pulmonary disease such as COPD based upon comparison of the variant and normal versions of the gene or gene product, and development of cell-culture …
Patent
Publication NumberUS 9885085Filing StatusIssued PatentAvailabilityUnknownFiling Date2007-06-28Publication Date2018-02-06
Methods are disclosed for generating and isolating an informative content repository of respiratory related biomarkers to accurately determine whether an individual has normal or abnormal pulmonary function. Specifically, methods are directed to determination of whether individuals have chronic obstructive pulmonary disease, and if so, whether the affected individuals experience rapid long decline or slow lung decline as a result of COPD. Also disclosed is an informative content repository of…
Patent
Publication NumberUS 20180004895Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-07-14Publication Date2018-01-04
The present invention relates to methods of detecting differentially expressed protein expression indicative of COPD in a test sample. The detection of circulating levels of proteins within an identified COPD biomarker signature can aid in COPD diagnosis and disease monitoring, as well as in the prediction of responses to therapeutics. Evaluation of the biomarker signatures disclosed, or a subset of biomarkers thereof, provides a level of discrimination not found with individual markers.
Patent
Publication NumberWO 2017210456 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-06-01Publication Date2017-12-07
An apparatus includes a database storing: a set of sequences, each associated with a different individual; location information for each region from a set of regions; and for each individual, a characteristic. The apparatus also includes a processor for generating, for each region, a first element matrix for a first element at a first element location in each sequence. The processor also generates a region matrix based on the first element matrix and estimates a first correlation between the …
Patent
Publication NumberUS 9823204Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-07-03Publication Date2017-11-21
Chronic obstructive pulmonary disease (COPD), characterized by chronic airflow limitation, is a serious and growing public health concern. The major environmental risk factor for COPD is cigarette smoking, but the biological mechanisms underlying COPD are not well understood. Herein, proton nuclear magnetic resonance (1H-NMR) spectroscopy is used in methods to identify metabolites and biomarkers associated with lung function in COPD.
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Patents: 66
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