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Patent
Publication NumberUS 20200095296Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-06-04Publication Date2020-03-26
The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit iron a therapy, assessing whether a subject afflicted with …
Patent
Publication NumberUS 20200085756Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-07-12Publication Date2020-03-19
Non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin are provided. The particles are porous, cage-like nanoparticles, also referred to as nanocages, and are typically between about 30 nm and about 60 nm. In some embodiments, the nanocages include or are administered in combination with an antigen. The particles can increase immune responses and are particularly useful as adjuvants in vaccine applications and related meth…
Patent
Publication NumberUS 20200078401Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-12-07Publication Date2020-03-12
Global transcriptional profiling of CTLs in tumors and adjacent non-tumor tissue from treatment-naive patients with early stage lung cancer revealed molecular features associated with robustness of anti-tumor immune responses. Major differences in the transcriptional program of tumor-infiltrating CTLs were observed that are shared across tumor subtypes. Pathway analysis revealed enrichment of genes in cell cycle, T cell receptor (TCR) activation and co-stimulation pathways, indicating tumor-d…
Publication
ID32165624Published Date2020-03-12JournalNature communications, 2020-03-12, Volume 11
While the ontogeny and recruitment of the intestinal monocyte/macrophage lineage has been studied extensively, their precise localization and function has been overlooked. Here we show by imaging the murine small and large intestines in steady-state that intestinal CX3CR1 macrophages form an interdigitated network intimately adherent to the entire mucosal lamina propria vasculature. The macrophages form contacts with each other, which are disrupted in the absence of microbiome, monocyte recru…
Research Grant
Project Number1K99CA248835-01Funding AgencyNational Institutes of HealthEffective Date2020-03-10Expiration Date2021-02-28Funding Amount$144,720
Abstract TET-family of dioxygenases mediate DNA demethylation by sequentially oxidizing 5-methylcytosine (5mC) to 5- hydroxymethyl- (5hmC), 5-formyl- (5fC) and 5-carboxyl-cytosine (5caC). TET enzymes are required for normal development and loss-of TET function due to mutations, metabolic reprogramming, hypoxia and other additional mechanisms occurs frequently in many hematological malignancies and solid tumors. Recent studies have identified mutations in TET proteins and metabolic enzymes whi…
Research Grant
Project Number1U01AI150753-01Funding AgencyNational Institutes of HealthEffective Date2020-03-10Expiration Date2021-02-28Funding Amount$1,391,377
Project Summary/Abstract: Bordetella pertussis (PT) is the causative agent of whooping cough. Highly effective vaccines to protect from PT infection have been in use since the early 1940s. However, the last fifteen years have witnessed a consistent increase in the number of whooping cough cases, and the reasons for this are not completely understood. This highlights the need to better understand how immune responses against PT vary between individuals, which we can determine by measuring immu…
Research Grant
Project Number2R01AI109842-32A1Funding AgencyNational Institutes of HealthEffective Date2020-03-10Expiration Date2021-02-28Funding Amount$669,740
ABSTRACT Blocking antibodies to CTLA4, PD-1, and other inhibitory surface receptors expressed on exhausted T cells, or blocking antibodies to the PD-1 ligands PD-L1 and PD-L2 expressed by tumor and stromal cells, have been remarkably successful at promoting long-term tumor regression. Combinations of blocking antibodies to multiple inhibitory receptors, often reinforced with activating antibodies to costimulatory receptors, have been more effective than treatment with individual blocking anti…
Publication
ID32122909Published Date2020-03-02JournalCancer research, 2020-03-02
Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have many tumor-promoting functions and promote immune evasion through multiple mechanisms, but as yet, no CAF-specific inhibitors are clinically available. Here we generated CAF-rich murine tumor models (TC1, MC38, and 4T1) to investigate how CAFs influence the immune microenvironment and affect response to different immunother…
Research Grant
Project Number5U19AI142742-02Funding AgencyNational Institutes of HealthEffective Date2020-03-01Expiration Date2021-02-28Funding Amount$190,992
Sequencing and Epigenetics Core (Core C) Core Summary The proposed projects in this CCHI program will use genetic approaches to define comprehensive molecular properties of specific immune cells in different aspects of immune responses in different diseases and after vaccination from blood and human clinical tissues (lymph nodes and lung tissue). Facing the inherent challenge, of cell abundance and heterogeneity when working with human samples, the CCHI Sequencing and Epigenetics Core, unlike…
Research Grant
Project Number1F31DK124078-01A1Funding AgencyNational Institutes of HealthEffective Date2020-03-01Expiration Date2021-02-28Funding Amount$39,934
PROJECT SUMMARY/ABSTRACT CD4 cytotoxic T lymphocytes (CTL) accumulate in the small intestinal epithelium during steady state, but their development and purpose(s) at this barrier are largely unknown. The unique localization of CD4 CTL to the small intestinal epithelium suggests tissue-specific properties that direct CD4 CTL to develop from naive CD4 T helper (Th) cells. Similar to traditional myeloid antigen-presenting cells, intestinal epithelial cells (IECs) express MHC class II (MHCII), su…
We found 3,785 documents that match your Search
Research Grants: 1,367
Publications: 1,905
Patents: 291
Clinical Trials: 4
Web Documents: 218

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